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Fizzah Iqbal Department of Endocrinology, University Hospital Plymouth, Plymouth, UK

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William Adams Department of Radiology, University Hospital Plymouth, Plymouth, UK

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Ioannis Dimitropoulos Department of Endocrinology, University Hospital Plymouth, Plymouth, UK

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Samiul Muquit Department of Neurosurgery, University Hospital Plymouth, Plymouth, UK

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Daniel Flanagan Department of Endocrinology, University Hospital Plymouth, Plymouth, UK

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.21–10.82 Proportion requiring oestrogen replacement 4/15 3/14 0.75 1 0.14–4.17 Proportion requiring desmopressin 3/31 1/19 2.04 1.0 0.20–21.07 Proportion taking dopamine agonist 3/33 4/22 0.29 0.20 0

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Anastasia P Athanasoulia-Kaspar Clinical Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany

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Matthias K Auer Clinical Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany

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Günter K Stalla Clinical Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany

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Mira Jakovcevski Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany

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human GH; 51 (44.3%) suffered from gonadotropic insufficiency and 67 (58.3%) were hypothyroid (all on levothyroxine replacement), whereas 18 presented with diabetes insipidus and were under substitution with desmopressin and 52 patients were diagnosed

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Anna Sjöström Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden

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Susanne Rysz Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden
Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

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Henrik Sjöström Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Center for Neurology, Academic Specialist Center, Stockholm, Sweden

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Charlotte Höybye Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden

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, synthetic AVP (desmopressin) is used as procoagulant treatment, for example, in von Willebrand’s disease (vWD), as it increases platelet release of coagulation factor VIII and von Willebrand factor after administration. During admission when the patients

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Mikkel Andreassen Department of Endocrinology, Faculty of Health Science, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Anders Juul Department of Growth and Reproduction, Faculty of Health Science, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Ulla Feldt-Rasmussen Department of Endocrinology, Faculty of Health Science, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Niels Jørgensen Department of Growth and Reproduction, Faculty of Health Science, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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 Craniopharyngioma 1  Medulla blastoma 1  Hypophysitis 1 Hormone substitution  Thyroxine 5  Hydrocortisone 5  Growth hormone 1  Desmopressin 1 Other treatments  Somatostatin analogs 2

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Morten Winkler Møller Department of Neurosurgery, Odense University Hospital, Odense C, Denmark
Clinical Institute, University of Southern Denmark, Odense C, Denmark

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Marianne Skovsager Andersen Clinical Institute, University of Southern Denmark, Odense C, Denmark
Department of Endocrinology, Odense University Hospital, Odense C, Denmark

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Christian Bonde Pedersen Department of Neurosurgery, Odense University Hospital, Odense C, Denmark
Clinical Institute, University of Southern Denmark, Odense C, Denmark

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Bjarne Winther Kristensen Clinical Institute, University of Southern Denmark, Odense C, Denmark
Department of Pathology, Odense University Hospital, Odense C, Denmark

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Frantz Rom Poulsen Department of Neurosurgery, Odense University Hospital, Odense C, Denmark
Clinical Institute, University of Southern Denmark, Odense C, Denmark

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insipidus Four patients had DI preoperatively. In one patient, this disappeared after surgery. Overall, 18% (12/67) patients required postsurgical desmopressin treatment permanently in the iMRI group vs 23% (26/113) in the control group. Transient

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Mette Marie Baunsgaard Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark

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Anne Sophie Lind Helligsoe Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark

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Louise Tram Henriksen Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark

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Torben Stamm Mikkelsen Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark

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Michael Callesen Department of Paediatrics, Odense University Hospital, Odense, Funen, Denmark

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Britta Weber The Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark

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Henrik Hasle Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark

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Niels Birkebæk Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark

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.7 (12.5–12.9) Current hormone replacement therapy other that GH  Sex hormones a 12 29  1  5  Desmopressin  3  7  0  0  Thyroid hormone 18 44  1  5  Hydrocortisone  8 20  0  0 Age

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Amir H Zamanipoor Najafabadi Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
Department of Medicine, Division of Endocrinology and Centre for Endocrine Tumors, Leiden University Medical Centre, Leiden, The Netherlands
Department of Neurosurgery, University Neurosurgical Centre Holland (UNCH), Leiden University Medical Centre, Haaglanden Medical Centre and Haga Teaching Hospitals, Leiden and The Hague, The Netherlands

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Merel van der Meulen Department of Medicine, Division of Endocrinology and Centre for Endocrine Tumors, Leiden University Medical Centre, Leiden, The Netherlands

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Ana Luisa Priego Zurita Department of Medicine, Division of Endocrinology and Centre for Endocrine Tumors, Leiden University Medical Centre, Leiden, The Netherlands

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S Faisal Ahmed Chair of Work Package of E-Health & ICT of Endo-ERN, Developmental Endocrinology Research Group, School of Medicine, Dentistry & Nursing, University of Glasgow and Office for Rare Conditions, Royal Hospital for Children & Queen Elizabeth University Hospital, Glasgow, UK

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Wouter R van Furth Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands

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Evangelia Charmandari Pediatric Chair Main Thematic Group 6 Pituitary of Endo-ERN, Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, ‘Aghia Sophia’ Children’s Hospital, Athens, Greece

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Olaf Hiort Pediatric Chair and Deputy Coordinator of Endo-ERN, Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University of Lübeck, Lübeck, Germany

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Alberto M Pereira Adult Chair and Coordinator of Endo-ERN, Department of Endocrinology and Metabolism, Amsterdam University Medical Center, Amsterdam, The Netherlands

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Mehul Dattani London Centre for Pediatric Endocrinology and Diabetes at Great Ormond Street Children's Hospital and University College London Hospitals, London, UK

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Diana Vitali SOD ITALIA (Italian Organization for Septo Optic Dysplasia and other Neuroendocrine Disorders), European Patient Advocacy Group, Rome, Italy

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Johan P de Graaf Dutch Pituitary Foundation, European Patient Advocacy Group, Nijkerk, The Netherlands

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Nienke R Biermasz Adult Chair Main Thematic Group 6 Pituitary of Endo-ERN, Department of Medicine, Division of Endocrinology and Centre for Endocrine Tumors, Leiden University Medical Centre, Leiden, The Netherlands

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insipidus separately, while only three studies provided a definition for permanent diabetes insipidus. One study defined it as the need for desmopressin for a minimum of 2 months, and another study used a 3 months timeframe. Four studies reported the

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Lukas Plachy Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu, Prague, Czech Republic

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Petra Dusatkova Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu, Prague, Czech Republic

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Klara Maratova Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu, Prague, Czech Republic

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Shenali Anne Amaratunga Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu, Prague, Czech Republic

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Dana Zemkova Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu, Prague, Czech Republic

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Vit Neuman Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu, Prague, Czech Republic

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Stanislava Kolouskova Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu, Prague, Czech Republic

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Barbora Obermannova Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu, Prague, Czech Republic

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Marta Snajderova Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu, Prague, Czech Republic

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Zdenek Sumnik Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu, Prague, Czech Republic

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Jan Lebl Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu, Prague, Czech Republic

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Stepanka Pruhova Department of Pediatrics, Second Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu, Prague, Czech Republic

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random sample or during a water deprivation test that adequately responded to desmopressin administration ( 19 ). The heights of all study participants were measured to the nearest 1 mm. Data regarding birth parameters, previous height development

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Liza Das Department of Endocrinology, Postgraduate Institute of Medical Education and Research, (PGIMER), Chandigarh, India

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Kim Vaiphei Department of Histopathology, PGIMER, Chandigarh, India

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Ashutosh Rai Department of Translational and Regenerative Medicine, PGIMER, Chandigarh, India

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Chirag Kamal Ahuja Department of Radiology, PGIMER, Chandigarh, India

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Paramjeet Singh Department of Radiology, PGIMER, Chandigarh, India

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Ishani Mohapatra Department of Pathology and Laboratory Medicine, Medanta, The Medicity, Gurgaon, India

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Rajesh Chhabra Department of Neurosurgery, PGIMER, Chandigarh, India

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Anil Bhansali Department of Endocrinology, Postgraduate Institute of Medical Education and Research, (PGIMER), Chandigarh, India

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Bishan Dass Radotra Department of Histopathology, PGIMER, Chandigarh, India

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Ashley B Grossman Centre for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Green Templeton College, University of Oxford, Oxford, UK

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Márta Korbonits Centre for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

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Pinaki Dutta Department of Endocrinology, Postgraduate Institute of Medical Education and Research, (PGIMER), Chandigarh, India

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. Histopathology showed a pituicytoma ( Fig. 3A , B , C and D ). The patient developed permanent DI which was managed with intranasal desmopressin. Post-operative MRI did not show any residual tumour. He is doing well without any residual disease documented on

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Ruth Percik Institute of Endocrinology, Diabetes and Metabolism, Sheba Medical Centre, Ramat Gan, Israel

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Sherwin Criseno Department of Endocrinology, University Hospital Birmingham, Birmingham, UK

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Safwaan Adam Department of Endocrinology, The Christie NHS Foundation Trust, Manchester, UK

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Kate Young Royal Marsden Hospital, London, UK

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Daniel L Morganstein Department of Endocrinology, Chelsea and Westminster Hospital, London, UK
Royal Marsden Hospital, London, UK

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urine volume greater than 50 mg/kg body weight; water deprivation test revealing diluted urine (osmolality below 100) when serum osmolality exceeds 295 mOsm/kg, followed by a desmopressin challenge leading to urine concentration above 300 mOsm

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