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A Rouland Endocrinology Diabetics and Metabolic Disorders Department, Dijon University Hospital, Dijon, France

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J-C Chauvet-Gelinier Psychiatry Unit, Department of Neurosciences, Dijon University Hospital, Dijon, France
INSERM Unit, LNC-UMR 1231, University of Burgundy, Dijon, France

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A-L Sberna Endocrinology Diabetics and Metabolic Disorders Department, Dijon University Hospital, Dijon, France
INSERM Unit, LNC-UMR 1231, University of Burgundy, Dijon, France

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E Crevisy Endocrinology Diabetics and Metabolic Disorders Department, Dijon University Hospital, Dijon, France

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P Buffier Endocrinology Diabetics and Metabolic Disorders Department, Dijon University Hospital, Dijon, France

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T Mouillot Endocrinology Diabetics and Metabolic Disorders Department, Dijon University Hospital, Dijon, France

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J-M Petit Endocrinology Diabetics and Metabolic Disorders Department, Dijon University Hospital, Dijon, France
INSERM Unit, LNC-UMR 1231, University of Burgundy, Dijon, France

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B Vergès Endocrinology Diabetics and Metabolic Disorders Department, Dijon University Hospital, Dijon, France
INSERM Unit, LNC-UMR 1231, University of Burgundy, Dijon, France

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themselves, alone, in a quiet place. The tests measured Type A personality (Bortner scale) and for any potentially associated psychological confounders such as anxiety and depression. Hostility was not measured, as the Bortner scale is not designed for it

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Roberto Cosimo Melcangi Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy

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Livio Casarini Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy

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Marco Marino Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy

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Daniele Santi Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy

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Samantha Sperduti Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy

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Silvia Giatti Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy

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Silvia Diviccaro Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy

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Maria Grimoldi Neurology Division, Papa Giovanni XXIII Hospital, Bergamo, Italy

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Donatella Caruso Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy

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Guido Cavaletti Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University of Milano Bicocca, Monza, Italy

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Manuela Simoni Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy
Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy

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discontinuation of the treatment ( 2 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ). Beside adverse events in the sexual sphere, some patients interrupting the treatment by finasteride develop depression ( 16 , 17 , 18 , 20 , 21

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Elena Valassi Endocrinology Department, Germans Trias i Pujol Hospital and Research Institute, Badalona, Barcelona, Spain
IRCCS, Istituto Auxologico Italiano, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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Iacopo Chiodini IRCCS, Istituto Auxologico Italiano, Milan, Italy
Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy

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Richard A Feelders Division of Endocrinology, Erasmus Medical Centre, Rotterdam, Netherlands

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Cornelie D Andela Division of Endocrinology and Centre for Endocrine Tumours, Leiden University Medical Centre, Leiden, Netherlands

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Margueritta Abou-Hanna HRA Pharma Rare Diseases, Châtillon, France

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Sarah Idres HRA Pharma Rare Diseases, Châtillon, France

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Antoine Tabarin Department of Endocrinology and INSERM U862 University and CHU of Bordeaux, Pessac, France

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depression, the time taken to diagnose CS is often long, resulting in a significant number of patients with persistent sequelae and impairments in QoL ( 6 , 9 ). Given the burden of the disease, ideal CS treatment would include early diagnosis, curative

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Carla Scaroni Dipartimento di Medicina, U.O.C. Endocrinologia, Università di Padova, Padova, Italy

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Nora M Albiger Dipartimento di Medicina, U.O.C. Endocrinologia, Università di Padova, Padova, Italy

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Serena Palmieri Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico, Milan, Italy

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Davide Iacuaniello Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Napoli, Italy

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Chiara Graziadio Department of Experimental Medicine, University La Sapienza, Rome, Italy

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Luca Damiani Department of Medical Sciences, Endocrinology and Internal Medicine Section, University of Ferrara, Ferrara, Italy

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Marialuisa Zilio Dipartimento di Medicina, U.O.C. Endocrinologia, Università di Padova, Padova, Italy

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Antonio Stigliano Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, University La Sapienza, Rome, Italy

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Annamaria Colao Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Napoli, Italy

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Rosario Pivonello Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Napoli, Italy

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the Altogether to Beat Cushing’s Syndrome (ABC) study group
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to a tertiary endocrine center for suspected endogenous hypercortisolism. She had a long-standing diagnosis of type-1 DM and a psychiatric condition characterized by depression and anxiety that was treated with fluoxetine. She had experienced

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Jing Zhang Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China

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Zhiyong Zhao Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China

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Li Dong Department of Pathology, Lanzhou University Second Hospital, Lanzhou, China

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Tao Han Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China

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Guojin Zhang Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China

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Yuntai Cao Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China

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Junlin Zhou Department of Radiology, Lanzhou University Second Hospital, Lanzhou, China
Key Laboratory of Medical Imaging of Gansu Province, Lanzhou, China
Second Clinical School, Lanzhou University, Lanzhou, China

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, depression of saddle, pituitary stalk visibility, and pituitary gland visibility were observed and recorded. ADC maps were automatically generated after DWI. The ADCs of the solid part of the tumors were calculated from the original images. On a continuous

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S Westra Department of Internal Medicine, Medical Centre Alkmaar, Alkmaar, the Netherlands

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Y H M Krul-Poel Department of Internal Medicine, Medical Centre Alkmaar, Alkmaar, the Netherlands

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H J van Wijland Department of General Practice, DIAZON, Alkmaar, the Netherlands

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M M ter Wee Department of Epidemiology and Biostatistics, VU Medical Centre, Amsterdam, the Netherlands

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F Stam Department of Internal Medicine, Medical Centre Alkmaar, Alkmaar, the Netherlands

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P Lips Department of Internal Medicine, Endocrine Section, VU Medical Centre, Amsterdam, the Netherlands

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F Pouwer Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands

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S Simsek Department of Internal Medicine, Medical Centre Alkmaar, Alkmaar, the Netherlands

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prevalences of depression, fatigue and (neuropathic) pain were found resulting in a decreased quality of life ( 2 , 3 , 4 , 5 , 6 ). Depressive symptoms and fatigue in people with diabetes are related to an increased risk of developing diabetes

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Morten Ruge Center for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark

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Tea Skaaby Center for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark

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Anna-Maria Andersson Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Allan Linneberg Center for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark
Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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physical and cognitive function, psychiatric disorders like depression and a negative influence on emotional and social factors ( 6 ). Hypersomnia, on the other hand, is characterized by an increased amount of sleep, excessive daytime sleep or sleepiness

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Brendan J Nolan Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia

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Aviva S Frydman Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia

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Shalem Y Leemaqz College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia

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Meg Carroll Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia

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Mathis Grossmann Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia

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Jeffrey D Zajac Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia

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Ada S Cheung Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Victoria, Australia

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concentrations, and history of anxiety and/or depression. Baseline PSQI, K10, and Tanner stage are shown in Table 2 . Table 1 Baseline characteristics of the study participants. Data presented are mean (95% CI) or number (%). P -values <0.05 were

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Rolf Jorde Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway
Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway

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Guri Grimnes Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway
Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway

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vitamin D 40,000 IU per week, 20,000 IU per week, or placebo for 1 year. All subjects were also given 500 mg calcium daily. The primary end point was weight reduction after 1 year. The subjects met to visits every third month ( 17 ). The Depression study

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Michelle Hadjiconstantinou University of Leicester, Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital, Leicester, UK

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Hamidreza Mani University of Leicester, Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital, Leicester, UK
Department of Diabetes and Endocrinology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK

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Naina Patel University of Leicester, Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital, Leicester, UK

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Miles Levy Department of Diabetes and Endocrinology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK

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Melanie Davies University of Leicester, Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital, Leicester, UK
Department of Diabetes and Endocrinology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK

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Kamlesh Khunti University of Leicester, Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital, Leicester, UK

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Margaret Stone University of Leicester, Diabetes Research Centre, Leicester Diabetes Centre, Leicester General Hospital, Leicester, UK

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reports about the severity of PCOS and the negative impact it may have on womens’ wellbeing, including high levels psychological distress, depression and anxiety ( 8 , 18 , 19 , 20 ). Our findings also indicate that low self-esteem and low body image

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