Dafydd Aled Rees
Dafydd Aled Rees
Cardiff University, Cardiff, United Kingdom
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Deborah P Merke
Deborah P Merke
National Institutes of Health Clinical Center and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, USA
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Wiebke Arlt
Wiebke Arlt
MRC LMS, London, United Kingdom
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Aude Brac De La Perriere
Aude Brac De La Perriere
Hospices Civils de Lyon - GHE - Endocrinologie, Bron, France
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Angelica Linden Hirschberg
Angelica Linden Hirschberg
Karolinska Institute, Solna, Sweden
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark, and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
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John Newell-Price
John Newell-Price
The University of Sheffield, Sheffield, United Kingdom
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Alessandro Prete
Alessandro Prete
University of Birmingham, Birmingham, United Kingdom
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Nicole Reisch
Nicole Reisch
Endokrinologie, Nephrologie und weitere Sektionen - Medizinische Klinik und Poliklinik IV - Campus Innenstadt, München, Germany
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Nike M Stikkelbroeck
Nike M Stikkelbroeck
Radboud University Nijmegen, Nijmegen, Netherlands
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Philippe A Touraine
Philippe A Touraine
University Hospitals Pitié Salpêtrière - Charles Foix, Paris, France
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Alex Lewis
Alex Lewis
Neurocrine Biosciences Inc, London, United Kingdom
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John Porter
John Porter
Neurocrine Biosciences Inc, London, United Kingdom
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Helen Coope
Helen Coope
Neurocrine Biosciences Inc, London, United Kingdom
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Richard J Ross
Richard J Ross
The University of Sheffield, Sheffield, United Kingdom
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adrenal androgens ( 1 ). To address this, clinicians have used a variety of treatment regimens, including the use of a higher dose of glucocorticoid at night in a reverse circadian treatment pattern. A recent comparison, using a higher dose of
Carla Scaroni
Carla Scaroni
Dipartimento di Medicina, U.O.C. Endocrinologia, Università di Padova, Padova, Italy
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Nora M Albiger
Nora M Albiger
Dipartimento di Medicina, U.O.C. Endocrinologia, Università di Padova, Padova, Italy
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Serena Palmieri
Serena Palmieri
Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico, Milan, Italy
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Davide Iacuaniello
Davide Iacuaniello
Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Napoli, Italy
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Chiara Graziadio
Chiara Graziadio
Department of Experimental Medicine, University La Sapienza, Rome, Italy
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Luca Damiani
Luca Damiani
Department of Medical Sciences, Endocrinology and Internal Medicine Section, University of Ferrara, Ferrara, Italy
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Marialuisa Zilio
Marialuisa Zilio
Dipartimento di Medicina, U.O.C. Endocrinologia, Università di Padova, Padova, Italy
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Antonio Stigliano
Antonio Stigliano
Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, University La Sapienza, Rome, Italy
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Annamaria Colao
Annamaria Colao
Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Napoli, Italy
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Rosario Pivonello
Rosario Pivonello
Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Napoli, Italy
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the Altogether to Beat Cushing’s Syndrome (ABC) study group
the Altogether to Beat Cushing’s Syndrome (ABC) study group
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suspected CS was confirmed by the lack of cortisol suppression after 1 mg dexamethasone (10 µg/dL, n.v. <1.8) and the absence of a cortisol circadian rhythm (midnight serum cortisol, MserC, 12 µg/dL; n.v. <7.5). Which clinical features are the
Ferdinand Roelfsema
Ferdinand Roelfsema
Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Diana van Heemst
Diana van Heemst
Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
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Ali Iranmanesh
Ali Iranmanesh
Endocrine Section, Medical Service, Salem Veterans Affairs Medical Center, Salem, Virginia, USA
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Paul Takahashi
Paul Takahashi
Primary Care Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
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Rebecca Yang
Rebecca Yang
Endocrine Research Unit, Mayo Medical and Graduate Schools, Clinical Translational Research Center, Mayo Clinic, Rochester, Minnesota, USA
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Johannes D Veldhuis
Johannes D Veldhuis
Endocrine Research Unit, Mayo Medical and Graduate Schools, Clinical Translational Research Center, Mayo Clinic, Rochester, Minnesota, USA
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1223 – 1228 . ( doi:10.1210/jc.2008-2543 ) 10.1210/jc.2008-2543 10 Sherman B Wysham C Pfohl B. Age-related changes in the circadian rhythm of plasma cortisol in man . Journal of Clinical Endocrinology and Metabolism 1985 61 439
Josef Köhrle
Josef Köhrle
Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institut für Experimentelle Endokrinologie, Berlin, Germany
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Martina Rauner
Martina Rauner
Department of Medicine III, Universitätsklinikum Dresden, Technische Universität Dresden, Dresden, Germany
Center for Healthy Aging, Universitätsklinikum Dresden, Technische Universität Dresden, Dresden, Germany
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Center for Healthy Aging, Universitätsklinikum Dresden, Technische Universität Dresden, Dresden, Germany
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Susan A Lanham-New
Susan A Lanham-New
Department of Nutritional Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
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receptor in retinal ganglion cells instructs the circadian clock of the suprachiasmatic nucleus and suppresses epiphysial melatonin production, as well as melanophore activation in the skin. This special series on 100 Years of Vitamin D, published in
Carlijn A Hoekx
Carlijn A Hoekx
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Borja Martinez-Tellez
Borja Martinez-Tellez
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
Department of Nursing Physiotherapy and Medicine, SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almería, Almería, Spain
Biomedical Research Unit, Torrecárdenas University Hospital, Almería, Spain
CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
Department of Nursing Physiotherapy and Medicine, SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almería, Almería, Spain
Biomedical Research Unit, Torrecárdenas University Hospital, Almería, Spain
CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain
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Maaike E Straat
Maaike E Straat
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Magdalena M A Verkleij
Magdalena M A Verkleij
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Mirjam Kemmeren
Mirjam Kemmeren
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Sander Kooijman
Sander Kooijman
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Martin Uhrbom
Martin Uhrbom
Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca Gothenburg, Sweden
Department of Medicine, Huddinge, Karolinska Institutet Campus Flemingsberg, Neo Building, Huddinge, Sweden
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Department of Medicine, Huddinge, Karolinska Institutet Campus Flemingsberg, Neo Building, Huddinge, Sweden
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Saskia C A de Jager
Saskia C A de Jager
Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
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Patrick C N Rensen
Patrick C N Rensen
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Mariëtte R Boon
Mariëtte R Boon
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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characteristics of this cohort has been extensively described elsewhere ( 12 ). To study the influence of circadian rhythm on cold-induced changes in serum GDF15 and FGF21 levels, a general linear model with repeated measures was used, with two within
Gavin P Vinson
Gavin P Vinson
School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK
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Caroline H Brennan
Caroline H Brennan
School of Biological and Chemical Sciences, Queen Mary University of London, London E1 4NS, UK
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Akhisaroglu M Ahmed R Manev H . The pineal gland is critical for circadian Period1 expression in the striatum and for circadian cocaine sensitization in mice . Neuropsychopharmacology 2003 28 2117 – 2123 . 174 Akhisaroglu M Ahmed R Kurtuncu
Gareth Leng
Gareth Leng
Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK
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the circadian rhythms of behaviour that persist in constant darkness. In lesioned hamsters, circadian rhythmicity can be restored by transplanting fragments of neonatal suprachiasmatic nucleus into the third ventricle – and, remarkably, can do so even
Stefan Schulz
Stefan Schulz
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Anika Mann
Anika Mann
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Benjamin Novakhov
Benjamin Novakhov
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Hugh D Piggins
Hugh D Piggins
Institute of Pharmacology and Toxicology, Faculty of Life Sciences, Jena University Hospital, Friedrich Schiller University Jena, Drackendorfer Straße 1, D-07747 Jena, Germany
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Amelie Lupp
Amelie Lupp
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receptor is involved in the regulation of normal rhythmic activity of the circadian clock, basal energy expenditure, immune response as well as male reproductive functions (1, 3, 32, 33, 34, 35, 36, 37) . In addition, it has been shown that copy number
Kerry V Fanson
Kerry V Fanson
Wildlife Reproductive Centre, School of Life and Environmental Sciences, School of Agriculture and Food Sciences, Taronga Conservation Society Australia, Dubbo, New South Wales, Australia
Wildlife Reproductive Centre, School of Life and Environmental Sciences, School of Agriculture and Food Sciences, Taronga Conservation Society Australia, Dubbo, New South Wales, Australia
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Wildlife Reproductive Centre, School of Life and Environmental Sciences, School of Agriculture and Food Sciences, Taronga Conservation Society Australia, Dubbo, New South Wales, Australia
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Tamara Keeley
Tamara Keeley
Wildlife Reproductive Centre, School of Life and Environmental Sciences, School of Agriculture and Food Sciences, Taronga Conservation Society Australia, Dubbo, New South Wales, Australia
Wildlife Reproductive Centre, School of Life and Environmental Sciences, School of Agriculture and Food Sciences, Taronga Conservation Society Australia, Dubbo, New South Wales, Australia
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Wildlife Reproductive Centre, School of Life and Environmental Sciences, School of Agriculture and Food Sciences, Taronga Conservation Society Australia, Dubbo, New South Wales, Australia
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Benjamin G Fanson
Benjamin G Fanson
Wildlife Reproductive Centre, School of Life and Environmental Sciences, School of Agriculture and Food Sciences, Taronga Conservation Society Australia, Dubbo, New South Wales, Australia
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) , humans (38) , pandas (39) , and sheep (40) ). The most detailed studies have been conducted in rats, and have shown that this increase is not due to overall upregulation of adrenal activity, but is due to a change in the amplitude of the circadian
Karim Gariani
Karim Gariani
Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospitals, Geneva, Switzerland
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Pedro Marques-Vidal
Pedro Marques-Vidal
Departments of Medicine and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland
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Gérard Waeber
Gérard Waeber
Departments of Medicine and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland
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Peter Vollenweider
Peter Vollenweider
Departments of Medicine and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland
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François R Jornayvaz
François R Jornayvaz
Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospitals, Geneva, Switzerland
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number of diabetes complications ( 19 ). Cortisol secretion follows a circadian rhythm with a nadir at midnight, starts to rise at 02:00–04:00 h, displays a peak briefly after waking up and then shows a progressive decrease during the day ( 20 ). The
