Jan-Bernd Stukenborg
Jan-Bernd Stukenborg
NORDFERTIL Research Lab Stockholm, Pediatric Endocrinology Unit, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, Stockholm, Sweden
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Kirsi Jahnukainen
Kirsi Jahnukainen
NORDFERTIL Research Lab Stockholm, Pediatric Endocrinology Unit, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, Stockholm, Sweden
Division of Haematology-Oncology and Stem Cell Transplantation, Children’s Hospital, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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Division of Haematology-Oncology and Stem Cell Transplantation, Children’s Hospital, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
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Marsida Hutka
Marsida Hutka
MRC Centre for Reproductive Health, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
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Rod T Mitchell
Rod T Mitchell
MRC Centre for Reproductive Health, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
Edinburgh Royal Hospital for Sick Children, Edinburgh, UK
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Edinburgh Royal Hospital for Sick Children, Edinburgh, UK
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relation to infertility, has been shown to be between 7.5 and 10 g/m 2 ( 48 , 49 , 50 ). However, a recent large study of non-irradiated childhood cancer survivors failed to identify any threshold dose for alkylating agent exposure that predicted
Julia Beckhaus
Julia Beckhaus
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Carl von Ossietzky Universität, Klinikum Oldenburg AöR, Oldenburg, Germany
Division of Epidemiology and Biometry, Carl von Ossietzky Universität, Oldenburg, Germany
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Division of Epidemiology and Biometry, Carl von Ossietzky Universität, Oldenburg, Germany
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Maria Eveslage
Maria Eveslage
Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany
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Brigitte Bison
Brigitte Bison
Diagnostic and Interventional Neuroradiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany
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Carsten Friedrich
Carsten Friedrich
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Carl von Ossietzky Universität, Klinikum Oldenburg AöR, Oldenburg, Germany
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Hermann L Müller
Hermann L Müller
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Carl von Ossietzky Universität, Klinikum Oldenburg AöR, Oldenburg, Germany
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parental BMI and hypothalamic damage with obesity at last visit during follow-up in childhood-onset CP survivors. Patients and methods Study design and participants 709 (351 (49.5) females/358 (50.5) males) diagnosed with adamantinomatous CP
Luminita Nicoleta Cima
Luminita Nicoleta Cima
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
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Anca Colita
Anca Colita
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Hematology Department, Fundeni Hospital, Bucharest, Romania
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Hematology Department, Fundeni Hospital, Bucharest, Romania
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Simona Fica
Simona Fica
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Endocrine Department, Elias Hospital, Bucharest, Romania
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Endocrine Department, Elias Hospital, Bucharest, Romania
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). Gonadal insufficiency and subsequent infertility are frequent problems that long-term HSCT survivors and their partners face with a negative impact on their QoL ( 4 , 5 ). Beside infertility, premature ovarian failure (POF) can have a significant impact
Greta B Raglan
Greta B Raglan
Department of Psychology, American University, Washington, District of Columbia, USA
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Louis A Schmidt
Louis A Schmidt
Department of Psychology, Neuroscience & Behavior, McMaster University, Hamilton, Ontario, Canada
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Jay Schulkin
Jay Schulkin
Department of Research, American College of Obstetricians and Gynecologists, Washington, District of Columbia, USA
Department of Neuroscience, Georgetown University, Washington, District of Columbia, USA
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Department of Neuroscience, Georgetown University, Washington, District of Columbia, USA
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. Urinary cortisol and catecholamines in mothers of child cancer survivors with and without PTSD. Psychoneuroendocrinology 2002 27 805 – 819 . ( doi:10.1016/s0306-4530(01)00081-6 ) 49 Yehuda R Engel SM Brand SR Seckle H Marcus SM
Julia Beckhaus
Julia Beckhaus
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Carl von Ossietzky University, Klinikum Oldenburg AöR, Oldenburg, Germany
Division of Epidemiology and Biometry, Carl von Ossietzky University, Oldenburg, Germany
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Division of Epidemiology and Biometry, Carl von Ossietzky University, Oldenburg, Germany
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Svenja Boekhoff
Svenja Boekhoff
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Carl von Ossietzky University, Klinikum Oldenburg AöR, Oldenburg, Germany
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Katrin Scheinemann
Katrin Scheinemann
Pediatric Hematology-Oncology Center, Children’s Hospital of Eastern Switzerland, St. Gallen, Switzerland
Faculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland
Department of Pediatrics, McMaster Children’s Hospital and McMaster University, Hamilton, Ontario, Canada
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Faculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland
Department of Pediatrics, McMaster Children’s Hospital and McMaster University, Hamilton, Ontario, Canada
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Freimut H Schilling
Freimut H Schilling
Department of Pediatrics, Division of Pediatric Hematology and Oncology, Children’s Hospital Lucerne, Lucerne, Switzerland
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Gudrun Fleischhack
Gudrun Fleischhack
Pediatrics III, University Hospital of Essen, Essen, Germany
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Gerhard Binder
Gerhard Binder
University Children’s Hospital, Pediatric Endocrinology, University Tübingen, Tübingen, Germany
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Brigitte Bison
Brigitte Bison
Diagnostic and Interventional Neuroradiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany
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Torsten Pietsch
Torsten Pietsch
Institute of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany
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Carsten Friedrich
Carsten Friedrich
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Carl von Ossietzky University, Klinikum Oldenburg AöR, Oldenburg, Germany
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Hermann L Müller
Hermann L Müller
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Carl von Ossietzky University, Klinikum Oldenburg AöR, Oldenburg, Germany
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increases the risk of cardiovascular complications and may result in a shorter life expectancy compared to a healthy population of the same age ( 16 , 17 , 18 , 19 ). In contrast to other cancer survivors, children with childhood-onset CP suffer from
J Van Schaik
J Van Schaik
Division of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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M Burghard
M Burghard
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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M H Lequin
M H Lequin
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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E A van Maren
E A van Maren
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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A M van Dijk
A M van Dijk
Department of Dietetics, University Medical Center Utrecht, Utrecht, The Netherlands
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T Takken
T Takken
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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L B Rehorst-Kleinlugtenbelt
L B Rehorst-Kleinlugtenbelt
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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B Bakker
B Bakker
Division of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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L Meijer
L Meijer
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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E W Hoving
E W Hoving
Division of Neurosurgery, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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M Fiocco
M Fiocco
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Institute of Mathematics, Leiden University, Leiden, The Netherlands
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Institute of Mathematics, Leiden University, Leiden, The Netherlands
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A Y N Schouten-van Meeteren
A Y N Schouten-van Meeteren
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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W J E Tissing
W J E Tissing
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
Division of Pediatric Oncology, University Medical Centre Groningen, Groningen, The Netherlands
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Division of Pediatric Oncology, University Medical Centre Groningen, Groningen, The Netherlands
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H M van Santen
H M van Santen
Division of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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of childhood brain tumors . Cancer 2010 116 3034 – 3044 . ( https://doi.org/10.1002/cncr.25051 ) 8 Zhang FF Saltzman E Must A Parsons SK . Do childhood cancer survivors meet the diet and physical activity guidelines? A review of guidelines
Agnieszka Bogusz
Agnieszka Bogusz
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Klinikum Oldenburg AöR, Oldenburg, Germany
Department of Endocrinology and Diabetology, The Children’s Memorial Health Institute, Warsaw, Poland
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Department of Endocrinology and Diabetology, The Children’s Memorial Health Institute, Warsaw, Poland
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Svenja Boekhoff
Svenja Boekhoff
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Klinikum Oldenburg AöR, Oldenburg, Germany
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Monika Warmuth-Metz
Monika Warmuth-Metz
Department of Neuroradiology, University Hospital, Würzburg, Germany
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Gabriele Calaminus
Gabriele Calaminus
Department of Pediatric Oncology and Hematology, University Hospital, Bonn, Germany
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Maria Eveslage
Maria Eveslage
Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany
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Hermann L Müller
Hermann L Müller
Department of Pediatrics and Pediatric Hematology/Oncology, University Children’s Hospital, Klinikum Oldenburg AöR, Oldenburg, Germany
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declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. Funding This study was funded by a grant (H L M; DKS2014.13) of The German Childhood Cancer Foundation, Bonn, Germany
Kevin C J Yuen
Kevin C J Yuen
Departments of Neuroendocrinology and Neurosurgery, Barrow Neurological Institute, University of Arizona College of Medicine and Creighton School of Medicine, Phoenix, Arizona, United States
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Gudmundur Johannsson
Gudmundur Johannsson
Department of Endocrinology, Sahlgrenska University Hospital and Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Ken K Y Ho
Ken K Y Ho
The Garvan Institute of Medical Research and the Faculty of Medicine, University of New South Wales, Sydney, Australia
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Bradley S Miller
Bradley S Miller
Pediatric Endocrinology, University of Minnesota Medical School, M Health Fairview Masonic Children’s Hospital, Minneapolis, Minnesota, United States
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Ignacio Bergada
Ignacio Bergada
Centro de Investigaciones Endocrinológicas "Dr César Bergadá" (CEDIE), CONICET-FEI-División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina
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Alan D Rogol
Alan D Rogol
Pediatric Diabetes and Endocrinology, University of Virginia, Charlottesville, Virginia, United States
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idiopathic and isolated, without other pituitary hormone deficiencies. Other less common causes of CO-GHD include congenital, structural, and acquired causes ( 4 , 5 , 7 ) ( Table 1 ). Importantly, childhood cancer survivors especially those who had
Luca Persani
Luca Persani
Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Biagio Cangiano
Biagio Cangiano
Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Marco Bonomi
Marco Bonomi
Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
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risk, such as those on follow-up for hypothalamic/pituitary lesions or brain cancer survivors, or the carriers of pathogenic variants in novel candidate genes, the diagnosis of CeH can be supported by several investigations or findings ( 35 ). These
Gudmundur Johannsson
Gudmundur Johannsson
Department of Internal Medicine and Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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Martin Bidlingmaier
Martin Bidlingmaier
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany
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Beverly M K Biller
Beverly M K Biller
Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
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Margaret Boguszewski
Margaret Boguszewski
Federal University of Parana, Curitiba, Brazil
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Felipe F Casanueva
Felipe F Casanueva
Department of Medicine, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain
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Philippe Chanson
Philippe Chanson
Assistance Publique-Hôpitaux de Paris, and Inserm, Paris, France
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Peter E Clayton
Peter E Clayton
Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK
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Catherine S Choong
Catherine S Choong
Department of Endocrinology, Princess Margaret Hospital & School of Medicine, University of Western Australia, Western Australia, Australia
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David Clemmons
David Clemmons
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
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Mehul Dattani
Mehul Dattani
Great Ormond Street Institute of Child Health, London, UK
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Jan Frystyk
Jan Frystyk
Department of Endocrinology, Odense University Hospital, Odense, Denmark
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Ken Ho
Ken Ho
Princess Alexandra Hospital and University of Queensland, Brisbane, Australia
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Andrew R Hoffman
Andrew R Hoffman
Department of Medicine, Stanford University and VA Palo Health Care System, Palo Alto, California, USA
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Reiko Horikawa
Reiko Horikawa
National Center for Child Health and Development, Tokyo, Japan
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Anders Juul
Anders Juul
Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
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John J Kopchick
John J Kopchick
Edison Biotechnology Institute and Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, USA
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Xiaoping Luo
Xiaoping Luo
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
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Sebastian Neggers
Sebastian Neggers
Section of Endocrinology, Department of Medicine, Pituitary Centre Rotterdam, Erasmus University Medical Centre, Rotterdam, the Netherlands
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Irene Netchine
Irene Netchine
Service d’Explorations Fonctionnelles Endocriniennes, AP-HP, Hôpital Trousseau, Sorbonne Université, INSERM UMRs 938, Paris, France
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Daniel S Olsson
Daniel S Olsson
Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden
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Sally Radovick
Sally Radovick
Rutgers University-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
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Ron Rosenfeld
Ron Rosenfeld
Department of Pediatrics, Oregon Health Science University, Portland, Oregon, USA
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Richard J Ross
Richard J Ross
University of Sheffield, Sheffield, UK
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Katharina Schilbach
Katharina Schilbach
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Munich, Germany
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Paulo Solberg
Paulo Solberg
Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
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Christian Strasburger
Christian Strasburger
Charité-Universitätsmedizin, Berlin, Germany
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Peter Trainer
Peter Trainer
The Christie NHS Foundation Trust, University of Manchester, Manchester, UK
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Kevin C J Yuen
Kevin C J Yuen
Barrow Pituitary Center, Barrow Neurological Institute, Department of Neuroendocrinology, University of Arizona College of Medicine, Phoenix, Arizona, USA
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Kerstin Wickstrom
Kerstin Wickstrom
Medical Products Agency, Uppsala, Sweden
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Jens O L Jorgensen
Jens O L Jorgensen
Aarhus University Hospital, Aarhus, Denmark
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on behalf of the Growth Hormone Research Society
on behalf of the Growth Hormone Research Society
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in certain subgroup of patients, such as cancer survivors receiving spinal radiation. Bone age and decrease in growth velocity can be used as biomarkers for epiphyseal maturation to determine the time at which GH treatment should cease. Table 1
