Stephen A Martin
Stephen A Martin
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Kenneth A Philbrick
Kenneth A Philbrick
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Carmen P Wong
Carmen P Wong
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Dawn A Olson
Dawn A Olson
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Adam J Branscum
Adam J Branscum
Biostatistics Program, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Donald B Jump
Donald B Jump
Molecular Nutrition and Diabetes Research Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Charles K Marik
Charles K Marik
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
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Jonathan M DenHerder
Jonathan M DenHerder
Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA
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Jennifer L Sargent
Jennifer L Sargent
Carlson College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA
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Russell T Turner
Russell T Turner
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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Urszula T Iwaniec
Urszula T Iwaniec
Skeletal Biology Laboratory, School of Biological and Population Health Sciences, Oregon State University, Corvallis, Oregon, USA
Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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Center for Healthy Aging Research, Oregon State University, Corvallis, Oregon, USA
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sympathetic outflow from the central nervous system (CNS) to brown adipose tissue (BAT), where heat is generated through the uncoupling of oxidation and phosphorylation by uncoupling proteins (UCPs) ( 9 ). Bone is highly innervated by efferent sympathetic
Eric M Ndombi
Eric M Ndombi
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Valentine Budambula
Valentine Budambula
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Mark K Webale
Mark K Webale
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Francis O Musumba
Francis O Musumba
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Jesca O Wesongah
Jesca O Wesongah
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Erick Mibei
Erick Mibei
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Aabid A Ahmed
Aabid A Ahmed
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Raphael Lihana
Raphael Lihana
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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Tom Were
Tom Were
Bomu Hospital, Department of Pathology, Department of Environment and Health Sciences, Department of Biomedical Sciences and Technology, Department of Medical Laboratory Sciences, Kapkatet Campus, Centre for Virus Research, Department of Medical Laboratory Sciences, Mombasa, Kenya
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develop in HIV infected individuals. For instance, accumulation of visceral and dorso-cervical adipose tissue, breast enlargement, and loss of facial and limb subcutaneous fat are attributable to anti-retroviral drugs, especially nucleoside reverse
Shane M Regnier
Shane M Regnier
Committee on Molecular Metabolism and Nutrition, Chicago, Illinois, USA
Pritzker School of Medicine, Chicago, Illinois, USA
University of Chicago, Chicago, Illinois, USA
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Pritzker School of Medicine, Chicago, Illinois, USA
University of Chicago, Chicago, Illinois, USA
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Andrew G Kirkley
Andrew G Kirkley
University of Chicago, Chicago, Illinois, USA
Committee on Molecular Pathogenesis and Molecular Medicine, Chicago, Illinois, USA
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Committee on Molecular Pathogenesis and Molecular Medicine, Chicago, Illinois, USA
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Daniel Ruiz
Daniel Ruiz
Committee on Molecular Metabolism and Nutrition, Chicago, Illinois, USA
University of Chicago, Chicago, Illinois, USA
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University of Chicago, Chicago, Illinois, USA
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Wakanene Kamau
Wakanene Kamau
University of Chicago, Chicago, Illinois, USA
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Qian Wu
Qian Wu
Wadsworth Center, New York Department of Health, Albany, New York, USA
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Kurunthachalam Kannan
Kurunthachalam Kannan
Wadsworth Center, New York Department of Health, Albany, New York, USA
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Robert M Sargis
Robert M Sargis
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
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have shown that TF augments adipogenesis in vitro ( 18 ) and promotes insulin resistance in rodent and human adipose tissues exposed ex vivo ( 19 ). These effects are postulated to result from activation of adipocytic glucocorticoid receptor (GR
Xiaoxia Jia
Xiaoxia Jia
Center for Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Yaxin An
Yaxin An
Center for Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Yuechao Xu
Yuechao Xu
Center for Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Yuxian Yang
Yuxian Yang
Center for Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Chang Liu
Chang Liu
Center for Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Dong Zhao
Dong Zhao
Center for Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Jing Ke
Jing Ke
Center for Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China
Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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Beijing Key Laboratory of Diabetes Research and Care, Beijing, China
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depot, while perirenal fat mainly consists of dormant brown adipose tissue ( 16 ). However, perirenal fat is more active in energy metabolism and adipokine secretion compared with typical visceral fat ( 12 ). It has been proved that massive perirenal fat
Jana Ernst
Jana Ernst
Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse, Halle (Saale), Germany
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Katharina Gert
Katharina Gert
Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse, Halle (Saale), Germany
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Frank Bernhard Kraus
Frank Bernhard Kraus
Central Laboratory, University Hospital Halle (Saale), Ernst-Grube-Strasse, Halle (Saale), Germany
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Ulrike Elisabeth Rolle-Kampczyk
Ulrike Elisabeth Rolle-Kampczyk
Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany
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Martin Wabitsch
Martin Wabitsch
Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
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Faramarz Dehghani
Faramarz Dehghani
Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse, Halle (Saale), Germany
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Kristina Schaedlich
Kristina Schaedlich
Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse, Halle (Saale), Germany
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an enzyme machinery enabling them for the de novo synthesis of steroid hormones from cholesterol ( 8 ). Androgenic steroids exhibit a positive gradient from blood to adipose tissue with the precursor androstenedione and dehydroepiandrosterone as
Chan Sub Park
Chan Sub Park
Department of Breast and Thyroid Surgery, Kyungpook National University Chilgok Hospital, Buk-gu, Daegu, Republic of Korea
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Jihye Choi
Jihye Choi
Department of General Surgery, National Medical Center, Jung-gu, Seoul, Republic of Korea
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Min-Ki Seong
Min-Ki Seong
Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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Sung-Eun Hong
Sung-Eun Hong
Radiation Medicine Clinical Research Division, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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Jae-Sung Kim
Jae-Sung Kim
Radiation Medicine Clinical Research Division, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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In-Chul Park
In-Chul Park
Division of Fusion Radiology Research, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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Hyesil Seol
Hyesil Seol
Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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Woo Chul Noh
Woo Chul Noh
Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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Hyun-Ah Kim
Hyun-Ah Kim
Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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depletion regimen regardless of menopausal status ( 13 ). In several recent pre-clinical studies, estradiol suppresses adipogenesis and activates brown adipose tissue ( 14 , 15 ). It might be a mechanism of action of estrogen replacement therapy, which
Jana Ernst
Jana Ernst
Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
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Urszula Grabiec
Urszula Grabiec
Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
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Kathrin Falk
Kathrin Falk
Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
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Faramarz Dehghani
Faramarz Dehghani
Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
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Kristina Schaedlich
Kristina Schaedlich
Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
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gonads, the liver as well in the hepatic lipid metabolism ( 29 , 30 , 31 ). DiNP exhibited adipogenic activity in murine 3T3-derived adipocytes ( 32 ). Adipose tissue expression of ECS components differs between lean and obese subjects as reflected by
Laurent Maïmoun
Laurent Maïmoun
Département de Médecine Nucléaire, Hôpital Lapeyronie, Centre Hospitalier Régional Universitaire (CHU) Montpellier, Montpellier, France
PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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Denis Mariano-Goulart
Denis Mariano-Goulart
Département de Médecine Nucléaire, Hôpital Lapeyronie, Centre Hospitalier Régional Universitaire (CHU) Montpellier, Montpellier, France
PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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Helena Huguet
Helena Huguet
Unité de Recherche Clinique et Epidémiologie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Eric Renard
Eric Renard
Departement d’Endocrinologie, Diabète, Nutrition, Hôpital Lapeyronie, CHRU Montpellier, Montpellier, France
CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
Institut de Génomique Fonctionnelle, CNRS UMR 5203/INSERM U661/Université Montpellier, Montpellier, France
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CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
Institut de Génomique Fonctionnelle, CNRS UMR 5203/INSERM U661/Université Montpellier, Montpellier, France
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Patrick Lefebvre
Patrick Lefebvre
Departement d’Endocrinologie, Diabète, Nutrition, Hôpital Lapeyronie, CHRU Montpellier, Montpellier, France
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Marie-Christine Picot
Marie-Christine Picot
Unité de Recherche Clinique et Epidémiologie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
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CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
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Anne-Marie Dupuy
Anne-Marie Dupuy
Département de Biochimie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Jean-Paul Cristol
Jean-Paul Cristol
PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
Département de Biochimie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département de Biochimie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Philippe Courtet
Philippe Courtet
Institut de Génomique Fonctionnelle, CNRS, INSERM Université Montpellier, Montpellier, France
Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Vincent Boudousq
Vincent Boudousq
Département de Médecine Nucléaire, Hôpital Carémeau, CHU Nîmes, Nîmes, France
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Antoine Avignon
Antoine Avignon
Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHU Montpellier, Montpellier, France
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Sébastien Guillaume
Sébastien Guillaume
Institut de Génomique Fonctionnelle, CNRS, INSERM Université Montpellier, Montpellier, France
Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Ariane Sultan
Ariane Sultan
PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHU Montpellier, Montpellier, France
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Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHU Montpellier, Montpellier, France
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by inducing the browning of s.c. white adipocytes, which are metabolically favourable for burning energy through thermogenesis ( 51 ). Depending on the experimental conditions (i.e. thermoneutral or cold), brown adipose tissue activity has been
Clarissa Souza Barthem
Clarissa Souza Barthem
Laboratório de Adaptações Metabólicas, Programa de Bioquímica e Biofísica Celular, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Camila Lüdke Rossetti
Camila Lüdke Rossetti
Laboratório de Adaptações Metabólicas, Programa de Bioquímica e Biofísica Celular, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Denise P Carvalho
Denise P Carvalho
Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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Wagner Seixas da-Silva
Wagner Seixas da-Silva
Laboratório de Adaptações Metabólicas, Programa de Bioquímica e Biofísica Celular, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
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) and soleus muscles, uterus,interscapular brown adipose tissue (BAT) and white adipose tissue depots (retroperitoneal, inguinal and gonadal) were excised, weighed and normalized to the rat tibia length. Serum analyses The levels of serum total
Devis Pascut
Devis Pascut
Fondazione Italiana Fegato – ONLUS, Trieste, Italy
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Sofia Tamini
Sofia Tamini
Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
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Silvia Bresolin
Silvia Bresolin
Laboratory of Onco-Hematology, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
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Pablo Giraudi
Pablo Giraudi
Fondazione Italiana Fegato – ONLUS, Trieste, Italy
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Giuseppe Basso
Giuseppe Basso
Laboratory of Onco-Hematology, Department of Women’s and Children’s Health, University of Padova, Padova, Italy
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Alessandro Minocci
Alessandro Minocci
Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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Claudio Tiribelli
Claudio Tiribelli
Fondazione Italiana Fegato – ONLUS, Trieste, Italy
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Graziano Grugni
Graziano Grugni
Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
Division of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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Division of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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Alessandro Sartorio
Alessandro Sartorio
Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, Milan and Piancavallo (VB), Italy
Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
Division of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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Division of Metabolic Diseases, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
Division of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy
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with obesity had already been proven ( 28 ). In particular, mir-92a-3p negatively correlated with the brown adipose tissue activity ( 29 ), while, the liver-enriched miR-122 was reported to work as central regulator of cholesterol and lipid metabolism
