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R H M Dykgraaf Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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S Schalekamp-Timmermans Division of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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M C Adank Division of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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S A A van den Berg Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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B M N van de Lang-Born Department of Clinical Chemistry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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T I M Korevaar Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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A Kumar Ansh Labs, Webster, Texas, USA

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B Kalra Ansh Labs, Webster, Texas, USA

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G V Savjani Ansh Labs, Webster, Texas, USA

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E A P Steegers Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Division of Obstetrics and Fetal Medicine, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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Y V Louwers Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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J S E Laven Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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pregnant of their first child and a minority (1.3%) achieved pregnancy through assisted reproductive technologies (ART) ( Table 1 ). Table 1 Baseline characteristics ( n   = 5806). Outcome Women Gestational age at blood sampling

Article Type:
Research Article
Collections:
Reproduction
DOI:
https://doi.org/10.1530/EC-22-0320
Volume/Issue:
Volume 12: Issue 3
Open access
Aglaia Kyrilli Department of Endocrinology, Hôpital Universitaire de Bruxelles (H.U.B.) - Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Bernard Corvilain Department of Endocrinology, Hôpital Universitaire de Bruxelles (H.U.B.) - Hôpital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium

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Sofie Bliddal Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Department of Gynecology and Obstetrics, Copenhagen University Hospital (Hvidovre Hospital), Hvidovre, Denmark

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Dorthe Hansen Precht Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Carelink Nærhospital, Roskilde, Denmark

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Ulla Feldt-Rasmussen Department of Medical Endocrinology and Metabolism, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
Institute of Clinical Medicine, Faculty of Health and Clinical Research, Copenhagen University, Copenhagen, Denmark

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Kris Poppe Department of Endocrinology, Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium
Université Libre de Bruxelles (ULB), Brussels, Belgium

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Committee (reference number 01-077/96). After exclusion of multiple pregnancies ( n = 2), thyroxine intake during pregnancy ( n = 2), pregnancies obtained by assisted reproductive technology ( n = 10), unknown gestational age at first visit ( n  = 11), no

Article Type:
Research Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-24-0151
Volume/Issue:
Volume 13: Issue 9
Open access
Mikkel Andreassen Department of Endocrinology, Faculty of Health Science, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Anders Juul Department of Growth and Reproduction, Faculty of Health Science, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Ulla Feldt-Rasmussen Department of Endocrinology, Faculty of Health Science, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Niels Jørgensen Department of Growth and Reproduction, Faculty of Health Science, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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proven fertile men, who had fathered children without use of assisted reproductive technologies (dotted line). The reference chart was based on measurements in men aged 20–45 years, n  = 307 (general population) and n  = 303 (proven fertile men). The

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0061
Volume/Issue:
Volume 7: Issue 4
Open access
Jyotsna S Jagai Division of Environmental and Occupational Health Sciences, School of Public Health, University of Illinois at Chicago, Chicago, Illinois, USA

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Alison K Krajewski Oak Ridge Institute for Science and Education, U.S. Environmental Protection Agency, Center for Public Health and Environmental Assessment, Public Health and Environmental Systems Division, Chapel Hill, North Carolina, USA
U.S. Environmental Protection Agency, Center for Public Health and Environmental Assessment, Research Triangle Park, North Carolina, USA

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Kyla N Price Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Danelle T Lobdell U.S. Environmental Protection Agency, Center for Public Health and Environmental Assessment, Research Triangle Park, North Carolina, USA

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Robert M Sargis Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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analysis and contributed to the writing of the manuscript. K N P assisted in the literature review and manuscript preparation. D T L led the team that developed the county-level estimates of environmental quality. R M S assisted in the conception and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0132
Volume/Issue:
Volume 10: Issue 9
Open access
Michael C Velarde Institute of Biology, College of Science, University of the Philippines Diliman, Quezon, Metro Manila, Philippines

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Mikaela Erlinda M Bucu Department of Obstetrics and Gynecology, College of Medicine, University of the Philippines Manila, Metro Manila, Philippines

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Maria Antonia E Habana Department of Obstetrics and Gynecology, College of Medicine, University of the Philippines Manila, Metro Manila, Philippines

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decade, as a definitive diagnosis is often established through surgery ( 9 ). Hence, affected women may live with the disease all throughout their reproductive years ( 10 ). Moreover, while several medications are available to manage the symptoms of

Article Type:
Review Article
Collections:
Reproduction
DOI:
https://doi.org/10.1530/EC-23-0169
Volume/Issue:
Volume 12: Issue 11
Open access
Teresa Vilariño-García Department of Medical Biochemistry, Molecular Biology and Immunology. Medical School, Virgen Macarena University Hospital, University of Seville, Seville, Spain

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Antonio Pérez-Pérez Department of Medical Biochemistry, Molecular Biology and Immunology. Medical School, Virgen Macarena University Hospital, University of Seville, Seville, Spain

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Esther Santamaría-López Valencian Infertility Institute (IVI), Seville, Spain

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Nicolás Prados Valencian Infertility Institute (IVI), Seville, Spain

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Manuel Fernández-Sánchez Valencian Infertility Institute (IVI), Seville, Spain

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Víctor Sánchez-Margalet Department of Medical Biochemistry, Molecular Biology and Immunology. Medical School, Virgen Macarena University Hospital, University of Seville, Seville, Spain

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follicular fluid leptin concentrations during assisted reproductive cycles in normal women and in women with the polycystic ovarian syndrome . Human Reproduction 2000 15 539 – 544 . ( https://doi.org/10.1093/humrep/15.3.539 )

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0062
Volume/Issue:
Volume 9: Issue 6
Open access
Wolfgang Koechling Ferring Pharmaceuticals A/S, Copenhagen, Denmark

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Daniel Plaksin Bio-Technology General Israel Ltd, Ferring Pharmaceuticals, Kiryat Malachi, Israel

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Glenn E Croston Croston Consulting, San Diego, California, USA

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Janni V Jeppesen The Laboratory of Reproductive Biology, The Department of Fertility at The Juliane Marie Centre, Rigshospitalet, Copenhagen University Hospital and The University of Copenhagen, Copenhagen, Denmark

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Kirsten T Macklon The Laboratory of Reproductive Biology, The Department of Fertility at The Juliane Marie Centre, Rigshospitalet, Copenhagen University Hospital and The University of Copenhagen, Copenhagen, Denmark

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Claus Yding Andersen The Laboratory of Reproductive Biology, The Department of Fertility at The Juliane Marie Centre, Rigshospitalet, Copenhagen University Hospital and The University of Copenhagen, Copenhagen, Denmark

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using a lymphoprep gradient (Stemcell Technologies, Grenoble, France) where fluid was maintained in the upper layer, while red blood cells were collected in the pellet and the granulosa cells were located in the intermediate layer. After aspiration of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0067
Volume/Issue:
Volume 6: Issue 5
Open access
Xingyan Liu Department of Obstetrics & Gynecology, General Hospital of PLA Eastern Theater (Nanjing General Hospital of Nanjing Military Command), Command, Nanjing, China

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Mei Xu Department of Obstetrics & Gynecology, General Hospital of PLA Eastern Theater (Nanjing General Hospital of Nanjing Military Command), Command, Nanjing, China

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Min Qian Department of Obstetrics & Gynecology, General Hospital of PLA Eastern Theater (Nanjing General Hospital of Nanjing Military Command), Command, Nanjing, China

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Lindong Yang Department of Obstetrics & Gynecology, General Hospital of PLA Eastern Theater (Nanjing General Hospital of Nanjing Military Command), Command, Nanjing, China

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Introduction Polycystic ovary syndrome (PCOS), characterized by oligo-anovulation, hyperandrogenism and polycystic ovarian morphology ( 1 ), is a heterogeneous endocrine metabolic disorder among which 3–10% of women in reproductive age had

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-21-0327
Volume/Issue:
Volume 10: Issue 12
Open access
Bogumila Urgatz Merck Healthcare KGaA, Darmstadt, Germany

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Kris G Poppe University Hospital CHU Saint Pierre, Free University of Brussels, Brussels, Belgium

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has been used widely in epidemiology studies that have associated hypothyroidism during pregnancy with adverse maternal and neonatal outcomes (see below). A 2021 guideline for the management of thyroid disorders in women undergoing assisted

Article Type:
Review Article
Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-23-0420
Volume/Issue:
Volume 13: Issue 3
Open access
Yao Su Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Li Chen Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Dong-Yao Zhang Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Xu-Pei Gan Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Yan-Nan Cao Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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De-Cui Cheng Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Wen-Yu Liu Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Fei-Fei Li Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Xian-Ming Xu Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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Hong-Kun Wang Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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surgical diseases present before pregnancy; (3) the use of assisted reproductive technology; or (4) a history of antibiotic use ≤2 months prior to enrollment. The study was approved by the ethics committee of the Shanghai General Hospital of the Shanghai

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0433
Volume/Issue:
Volume 10: Issue 11
Open access