Chunyun Fu
Chunyun Fu
Department of Genetic Metabolism, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
Medical Science Laboratory, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
Department of pathology, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
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Medical Science Laboratory, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
Department of pathology, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
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Shiyu Luo
Shiyu Luo
Department of Genetic Metabolism, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
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Yingfeng Li
Yingfeng Li
Medical Science Laboratory, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
Department of pathology, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
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Department of pathology, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
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Qifei Li
Qifei Li
Department of Genetic Metabolism, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
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Xuehua Hu
Xuehua Hu
Medical Science Laboratory, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
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Mengting Li
Mengting Li
Department of Genetic Metabolism, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
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Yue Zhang
Yue Zhang
Department of Genetic Metabolism, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
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Jiasun Su
Jiasun Su
Department of Genetic Metabolism, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
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Xuyun Hu
Xuyun Hu
Department of Genetic Metabolism, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
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Yun Chen
Yun Chen
Department of Genetic Metabolism, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
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Jin Wang
Jin Wang
Department of Genetic Metabolism, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
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Bobo Xie
Bobo Xie
Department of Genetic Metabolism, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
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Jingsi Luo
Jingsi Luo
Department of Genetic Metabolism, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
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Xin Fan
Xin Fan
Department of Genetic Metabolism, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
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Shaoke Chen
Shaoke Chen
Department of Genetic Metabolism, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
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Yiping Shen
Yiping Shen
Department of Genetic Metabolism, Children’s Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China
Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
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Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
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reported a CH prevalence of 1:666 (TSH cutoff level 10 IU/L) in East Azerbaijan, Iran ( 4 ), whereas a CH prevalence of 1:2591 (TSH cutoff level 10 IU/L) was reported in the Republic of Macedonia ( 5 ). Two previous studies reported the CH prevalence based
Chenjia Tang
Chenjia Tang
Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
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Yanting Dong
Yanting Dong
Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
Department of Endocrinology, Suichang County Hospital of Traditional Chinese Medicine, Lishui, China
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Department of Endocrinology, Suichang County Hospital of Traditional Chinese Medicine, Lishui, China
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Lusi Lu
Lusi Lu
Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
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Nan Zhang
Nan Zhang
Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
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-stimulating hormone (TSH) levels above the normal reference range. Recurrence was defined based on the relapse of clinical symptoms, such as neck pain, usually accompanied by an increase in CRP or ESR. All laboratory tests, ultrasonographic examinations, and thyroid
Aditya Dutta
Aditya Dutta
Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India
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Ganesh Jevalikar
Ganesh Jevalikar
Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India
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Rutuja Sharma
Rutuja Sharma
Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India
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Khalid J Farooqui
Khalid J Farooqui
Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India
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Shama Mahendru
Shama Mahendru
Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India
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Arun Dewan
Arun Dewan
Institute of Internal Medicine, Max Healthcare, Saket, New Delhi, India
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Sandeep Bhudiraja
Sandeep Bhudiraja
Institute of Internal Medicine, Max Healthcare, Saket, New Delhi, India
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Ambrish Mithal
Ambrish Mithal
Institute of Endocrinology and Diabetes, Max Healthcare, Saket, New Delhi, India
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impaired thyroid-stimulating hormone (TSH) secretion, decreased T3 and T4 (non-thyroidal illness; NTI), decreased activity of deiodinases and thyrotoxicosis ( 10 ). The pathophysiology behind these changes has been explained by the cytokine storm associated
Ningning Gong
Ningning Gong
Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China
Department of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, China
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Department of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu, China
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Cuixia Gao
Cuixia Gao
Department of Ultrasonic Diagnosis, Gansu Provincial Hospital, Lanzhou, China
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Xuedi Chen
Xuedi Chen
Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China
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Yu Wang
Yu Wang
Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China
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Limin Tian
Limin Tian
Department of Endocrinology, Gansu Provincial Hospital, Lanzhou, China
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Introduction Subclinical hypothyroidism (sHT) is defined by increased thyroid-stimulating hormone (TSH) with normal thyroid hormone concentrations. The prevalence of sHT is 4–20% in adults ( 1 ). Recently, a relationship between sHT and
Hana Vítková
Hana Vítková
Third Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
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Kateřina Anderlová
Kateřina Anderlová
Third Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
Department of Gynaecology, Obstetrics and Neonatology, First Faculty of Medicine Charles University and General University Hospital in Prague, Prague, Czech Republic
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Department of Gynaecology, Obstetrics and Neonatology, First Faculty of Medicine Charles University and General University Hospital in Prague, Prague, Czech Republic
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Jan Krátký
Jan Krátký
Third Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
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Radovan Bílek
Radovan Bílek
Institute of Endocrinology, Prague, Czech Republic
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Drahomíra Springer
Drahomíra Springer
Institute of Clinical Biochemistry and Laboratory Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
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Felix Votava
Felix Votava
Department of Children and Adolescents, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic
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Tomáš Brutvan
Tomáš Brutvan
Third Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
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Adéla Krausová
Adéla Krausová
Third Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
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Kristýna Žabková
Kristýna Žabková
Third Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
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Eliška Potluková
Eliška Potluková
University Center of Internal Medicine, Cantonal Hospital Baselland and University of Basel, Switzerland
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Jan Jiskra
Jan Jiskra
Third Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
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-stimulating hormone (TSH). Whereas thyroid volume and serum thyroglobulin indicate iodine nutrition over months or years, UIC and neonatal serum TSH reflect recent changes in iodine status and serve as sensitive markers of current iodine intake. Since the 1990s
Huixing Liu
Huixing Liu
Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
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Daoquan Peng
Daoquan Peng
Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
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Introduction Hypothyroidism, including overt and subclinical hypothyroidism is a common disease among people. The former is defined as increased serum thyroid-stimulating hormone (TSH) levels and reduced free peripheral thyroid hormone (TH
Stine Linding Andersen
Stine Linding Andersen
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Louise Knøsgaard
Louise Knøsgaard
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Aase Handberg
Aase Handberg
Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
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Peter Vestergaard
Peter Vestergaard
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Steno Diabetes Center North Jutland, Aalborg University Hospital, Aalborg, Denmark
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Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Steno Diabetes Center North Jutland, Aalborg University Hospital, Aalborg, Denmark
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Stig Andersen
Stig Andersen
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
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Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark
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Denmark Region, as previously described in detail ( 5 , 6 ). In 2017–2018, the samples were used for measurement of maternal thyroid-stimulating hormone (TSH), free T4 (fT4), free T3 (fT3), total T4 (TT4), total T3 (TT3), and T-uptake on a Cobas 8000
Dorte Glintborg
Dorte Glintborg
Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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Katrine Hass Rubin
Katrine Hass Rubin
OPEN – Odense Patient data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark
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Mads Nybo
Mads Nybo
Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
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Bo Abrahamsen
Bo Abrahamsen
OPEN – Odense Patient data Explorative Network, Department of Clinical Research, University of Southern Denmark and Odense University Hospital, Odense, Denmark
Department of Medicine, Holbæk Hospital, Holbæk, Denmark
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Department of Medicine, Holbæk Hospital, Holbæk, Denmark
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Marianne Andersen
Marianne Andersen
Department of Endocrinology, Odense University Hospital, Odense, Denmark
Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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Institute of Clinical Research, University of Southern Denmark, Odense, Denmark
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disease in PCOS. The possible clinical and metabolic side effects of subclinical hypothyroidism in PCOS are currently debated. A recent meta-analysis included TSH data from 577 women with PCOS and subclinical hypothyroidism (elevated TSH and normal
Nikolina Zdraveska
Nikolina Zdraveska
University Children’s Hospital Skopje, Faculty of Medicine, Skopje, Republic of Macedonia
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Maja Zdravkovska
Maja Zdravkovska
Institute of Patophysiology and Nuclear Medicine, Faculty of Medicine, Skopje, Republic of Macedonia
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Violeta Anastasovska
Violeta Anastasovska
University Children’s Hospital Skopje, Faculty of Medicine, Skopje, Republic of Macedonia
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Elena Sukarova-Angelovska
Elena Sukarova-Angelovska
University Children’s Hospital Skopje, Faculty of Medicine, Skopje, Republic of Macedonia
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Mirjana Kocova
Mirjana Kocova
University Children’s Hospital Skopje, Faculty of Medicine, Skopje, Republic of Macedonia
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neonatal screening was carried out by determination of whole-blood thyroid-stimulating hormone (TSH) on dried blood spot specimen obtained from newborns 48 to 72 h after birth by fluoroimmunometric DELFIA assay. The TSH cut-off level was 15 IU/L in the
Salman Razvi
Salman Razvi
Translational and Clinical Research Institute, University of Newcastle, Newcastle-upon-Tyne, UK
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Sanaa Mrabeti
Sanaa Mrabeti
Medical Affairs EMEA, Merck Serono Middle East FZ-LLC, Dubai, United Arab Emirates
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Markus Luster
Markus Luster
Department of Nuclear Medicine, University Hospital Marburg, Marburg, Germany
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Introduction Current management guidelines for the management of hypothyroidism focus on the administration of levothyroxine (LT4), with doses titrated to bring thyroid-stimulating hormone (thyrotropin, TSH) within a locally-derived reference
