Yun Cai
Yun Cai
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Jieni Yan
Jieni Yan
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Yong Gu
Yong Gu
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Heng Chen
Heng Chen
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Yang Chen
Yang Chen
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Xinyu Xu
Xinyu Xu
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Mei Zhang
Mei Zhang
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Liping Yu
Liping Yu
Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA
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Xuqin Zheng
Xuqin Zheng
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Tao Yang
Tao Yang
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
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DM) is the most frequent ( 3 , 4 , 5 ). The phenotype is referred as autoimmune polyendocrine syndrome type II (APS II) when T1DM and AITD occur in the same individual, even sometimes coexist in the same family ( 6 , 7 ). T1DM, as well as AITD
Zhiyan Yu
Zhiyan Yu
Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China
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Yueyue Wu
Yueyue Wu
Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China
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Rui Zhang
Rui Zhang
Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China
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Yue Li
Yue Li
Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China
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Shufei Zang
Shufei Zang
Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China
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Jun Liu
Jun Liu
Department of Endocrinology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China
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subjects with T2DM were included in this study of whom 654 were male (266 non-NAFLD, 388 NAFLD) and 589 were female (217 non-NAFLD and 372 NAFLD). The clinical and laboratory characteristics are shown in Table 1 . Compared with non-NAFLD patients, those
Jothydev Kesavadev
Jothydev Kesavadev
Jothydev’s Diabetes Research Centre, Trivandrum, Kerala, India
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Pradeep Babu Sadasivan Pillai
Pradeep Babu Sadasivan Pillai
Jothydev’s Diabetes Research Centre, Trivandrum, Kerala, India
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Arun Shankar
Arun Shankar
Jothydev’s Diabetes Research Centre, Trivandrum, Kerala, India
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Gopika Krishnan
Gopika Krishnan
Jothydev’s Diabetes Research Centre, Trivandrum, Kerala, India
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Sunitha Jothydev
Sunitha Jothydev
Jothydev’s Diabetes Research Centre, Trivandrum, Kerala, India
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shown to reduce HbA1c and delay the need for insulin therapy ( 5 ). Sitagliptin as add-on therapy in T2DM has reported to provide persistent beneficial effects on short-term, intermediate-term and long-term biomarkers of metabolic control, as well as on
Sweta Budyal
Sweta Budyal
Department of Endocrinology, Seth G S Medical College and KEM Hospital, Parel, Mumbai, Maharashtra 400012, India
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Swati Sachin Jadhav
Swati Sachin Jadhav
Department of Endocrinology, Seth G S Medical College and KEM Hospital, Parel, Mumbai, Maharashtra 400012, India
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Rajeev Kasaliwal
Rajeev Kasaliwal
Department of Endocrinology, Seth G S Medical College and KEM Hospital, Parel, Mumbai, Maharashtra 400012, India
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Hiren Patt
Hiren Patt
Department of Endocrinology, Seth G S Medical College and KEM Hospital, Parel, Mumbai, Maharashtra 400012, India
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Shruti Khare
Shruti Khare
Department of Endocrinology, Seth G S Medical College and KEM Hospital, Parel, Mumbai, Maharashtra 400012, India
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Vyankatesh Shivane
Vyankatesh Shivane
Department of Endocrinology, Seth G S Medical College and KEM Hospital, Parel, Mumbai, Maharashtra 400012, India
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Anurag R Lila
Anurag R Lila
Department of Endocrinology, Seth G S Medical College and KEM Hospital, Parel, Mumbai, Maharashtra 400012, India
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Tushar Bandgar
Tushar Bandgar
Department of Endocrinology, Seth G S Medical College and KEM Hospital, Parel, Mumbai, Maharashtra 400012, India
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Nalini S Shah
Nalini S Shah
Department of Endocrinology, Seth G S Medical College and KEM Hospital, Parel, Mumbai, Maharashtra 400012, India
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.8% (1.8) 4.1% (5) Our study India 993 1.8 μg/dl (50 nmol/l) Unselected T2DM outpatients 55.1±10.5 (25–87) 0 0/0/0 3.7% (1.8) a Limiting to the cross-sectional cohort alone. b s.e.m . c 2% (4/200 patients) had undergone treatment with definitive evidence
Peter L Kristensen
Peter L Kristensen
Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
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Ulrik Pedersen-Bjergaard
Ulrik Pedersen-Bjergaard
Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Rikke Due-Andersen
Rikke Due-Andersen
Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
Lægerne på Ellemarksvej, Køge, Denmark
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Lægerne på Ellemarksvej, Køge, Denmark
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Thomas Høi-Hansen
Thomas Høi-Hansen
Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
Department of Cardiology, Herlev-Gentofte University Hospital, Herlev, Denmark
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Department of Cardiology, Herlev-Gentofte University Hospital, Herlev, Denmark
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Lise Grimmeshave
Lise Grimmeshave
Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
Novo Nordisk A/S, Søborg, Denmark
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Novo Nordisk A/S, Søborg, Denmark
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Valeriya Lyssenko
Valeriya Lyssenko
Steno Diabetes Center, Gentofte, Denmark
Lund University Diabetes Centre, Skåne University Hospital, Malmø, Sweden
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Lund University Diabetes Centre, Skåne University Hospital, Malmø, Sweden
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Leif Groop
Leif Groop
Lund University Diabetes Centre, Skåne University Hospital, Malmø, Sweden
Finnish Institute for Molecular Medicine (FIMM), Helsinki University, Helsinki, Finland
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Finnish Institute for Molecular Medicine (FIMM), Helsinki University, Helsinki, Finland
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Jens J Holst
Jens J Holst
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Biomedical Sciences, NNF Center for Basic Metabolic Research, The Panum Institute, Copenhagen, Denmark
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Department of Biomedical Sciences, NNF Center for Basic Metabolic Research, The Panum Institute, Copenhagen, Denmark
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Allan A Vaag
Allan A Vaag
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Endocrinology, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
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Department of Endocrinology, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
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Birger Thorsteinsson
Birger Thorsteinsson
Department of Cardiology, Nephrology and Endocrinology, Nordsjællands Hospital, Hillerød, Denmark
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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candidate risk genes for type 2 diabetes, the T allele of rs7903146 transcription factor 7-like 2 ( TCF7L2 ) has been shown to confer the hitherto strongest association with type 2 diabetes, with a per allele odds ratio of 1.4 ( 22 , 23 , 24 ). During the
M Boering
M Boering
Isala, Diabetes Centre, Zwolle, The Netherlands
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P R van Dijk
P R van Dijk
Isala, Diabetes Centre, Zwolle, The Netherlands
Isala, Department of Internal Medicine, Zwolle, The Netherlands
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Isala, Department of Internal Medicine, Zwolle, The Netherlands
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S J J Logtenberg
S J J Logtenberg
Diakonessenhuis, Department of Internal Medicine, Utrecht, The Netherlands
Langerhans Medical Research group, Zwolle, The Netherlands
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Langerhans Medical Research group, Zwolle, The Netherlands
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K H Groenier
K H Groenier
Isala, Diabetes Centre, Zwolle, The Netherlands
Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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B H R Wolffenbuttel
B H R Wolffenbuttel
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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R O B Gans
R O B Gans
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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N Kleefstra
N Kleefstra
Isala, Diabetes Centre, Zwolle, The Netherlands
Langerhans Medical Research group, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Langerhans Medical Research group, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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H J G Bilo
H J G Bilo
Isala, Diabetes Centre, Zwolle, The Netherlands
Isala, Department of Internal Medicine, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Isala, Department of Internal Medicine, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Introduction Among type 1 diabetes mellitus (T1DM) patients, subcutaneous (SC) insulin administration is associated with low portal insulin concentrations and a consequent hepatic underinsulinization ( 1 ). Hepatic underinsulinization has been
Lili Liu
Lili Liu
Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Zhuo Shao
Zhuo Shao
Department of General Surgery, Changhai Hospital, The Second Military Medical University, Shanghai, Shanghai, China
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Ying Xia
Ying Xia
Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Jiabi Qin
Jiabi Qin
Department of Epidemiology & Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China
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Yang Xiao
Yang Xiao
Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Zhiguang Zhou
Zhiguang Zhou
Department of Metabolism & Endocrinology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Key Laboratory of Diabetes Immunology, Central South University, Ministry of Education, National Clinical Research Center for Metabolic Diseases, Changsha, Hunan, China
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Zubing Mei
Zubing Mei
Department of Anorectal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
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Introduction Type 1 diabetes mellitus (T1DM), which is caused by the selective destruction of the insulin-producing β cells located in the pancreatic islets of Langerhans, is one of the most common and debilitating autoimmune diseases ( 1
Giovanni Fanni
Giovanni Fanni
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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Petros Katsogiannos
Petros Katsogiannos
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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Bipasha Nandi Jui
Bipasha Nandi Jui
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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Magnus Sundbom
Magnus Sundbom
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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Susanne Hetty
Susanne Hetty
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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Maria J Pereira
Maria J Pereira
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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Jan W Eriksson
Jan W Eriksson
Department of Medical Sciences, Clinical Diabetes and Metabolism, Uppsala University, Uppsala, Sweden
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Introduction Besides inducing significant and durable weight loss, Roux-en-Y gastric bypass (RYGB) improves glycemic control in insulin-resistant patients and can prevent or reverse type 2 diabetes mellitus (T2DM) ( 1 , 2 , 3 ). This
C L Bodinham
C L Bodinham
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L Smith
L Smith
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E L Thomas
E L Thomas
Nutrition, Metabolic and Molecular Imaging Group, Department of Food and Nutritional Sciences, Metabolism and Diabetes Research Group, Faculty of Health and Medical Sciences, University of Surrey, Leggett Building, Guildford, Surrey GU2 7WG, UK
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J D Bell
J D Bell
Nutrition, Metabolic and Molecular Imaging Group, Department of Food and Nutritional Sciences, Metabolism and Diabetes Research Group, Faculty of Health and Medical Sciences, University of Surrey, Leggett Building, Guildford, Surrey GU2 7WG, UK
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J R Swann
J R Swann
Nutrition, Metabolic and Molecular Imaging Group, Department of Food and Nutritional Sciences, Metabolism and Diabetes Research Group, Faculty of Health and Medical Sciences, University of Surrey, Leggett Building, Guildford, Surrey GU2 7WG, UK
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A Costabile
A Costabile
Nutrition, Metabolic and Molecular Imaging Group, Department of Food and Nutritional Sciences, Metabolism and Diabetes Research Group, Faculty of Health and Medical Sciences, University of Surrey, Leggett Building, Guildford, Surrey GU2 7WG, UK
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D Russell-Jones
D Russell-Jones
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A M Umpleby
A M Umpleby
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M D Robertson
M D Robertson
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with well-controlled diabetes (mean HbA1c, 46.6 mmol/mol and target UK level for T2DM, 48 mmol/mol), taking oral hypoglycemics, HAM-RS2 intake resulted in a significant improvement in the meal glucose handling ( Fig. 1 ) without a change in medication
Yutong Zou
Yutong Zou
Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Lijun Zhao
Lijun Zhao
Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Junlin Zhang
Junlin Zhang
Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Yiting Wang
Yiting Wang
Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Yucheng Wu
Yucheng Wu
Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Honghong Ren
Honghong Ren
Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Tingli Wang
Tingli Wang
Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Rui Zhang
Rui Zhang
Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Jiali Wang
Jiali Wang
Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Yuancheng Zhao
Yuancheng Zhao
Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Chunmei Qin
Chunmei Qin
Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Huan Xu
Huan Xu
Division of Pathology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Lin Li
Lin Li
Division of Pathology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Zhonglin Chai
Zhonglin Chai
Department of Diabetes, Central Clinical School, Monash University, Melbourne, Australia
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Mark E Cooper
Mark E Cooper
Department of Diabetes, Central Clinical School, Monash University, Melbourne, Australia
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Nanwei Tong
Nanwei Tong
Division of Endocrinology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Fang Liu
Fang Liu
Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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and DN patients who had undergone percutaneous renal biopsy between January 2008 and July 2019 and had at least 1-year follow-up at the West China Hospital of Sichuan University were enrolled for the longitudinal observational study. T2DM was diagnosed
