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Anne H van der Spek Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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Olga V Surovtseva Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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Saskia Aan Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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Anton T J Tool Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands

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Annemarie van de Geer Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands

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Korcan Demir Division of Pediatric Endocrinology, Dokuz Eylül University, Izmir, Turkey

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Anja L M van Gucht Department of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands

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A S Paul van Trotsenburg Department of Pediatric Endocrinology, Academic Medical Center, Amsterdam, The Netherlands

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Timo K van den Berg Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, The Netherlands

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Eric Fliers Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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Anita Boelen Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands

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immune response. To answer this, we assessed circulating pro-inflammatory cytokine levels in a previously described patient with RTHα ( 19 ) and found elevated concentrations of interleukin-8 (IL-8). We then measured IL-8 in a larger cohort of 8 RTHα

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0213
Volume/Issue:
Volume 6: Issue 8
Open access
Clara Lundetoft Clausen Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark

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Trine Holm Johannsen Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark

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Niels Erik Skakkebæk Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark

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Hanne Frederiksen Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark

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Anders Juul Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Thomas Benfield Center of Research & Disruption of Infectious Diseases, Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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important inhibitory effects towards pro-inflammatory mediators such as interleukin 6 (IL-6) ( 10 ). Therefore, in appropriate responses to critical illness and hyperinflammation, glucocorticoid levels are upregulated, attaining levels up to six

Article Type:
Research Article
Collections:
Adrenal
DOI:
https://doi.org/10.1530/EC-24-0093
Volume/Issue:
Volume 13: Issue 8
Open access
R A M Quax Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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J A M van Laar Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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R van Heerebeek Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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K Greiner Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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E Ben-Chetrit Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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M Stanford Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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G R Wallace Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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F Fortune Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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M Ghabra Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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M Soylu Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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J M W Hazes Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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S W J Lamberts Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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J H Kappen Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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P M van Hagen Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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J W Koper Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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R A Feelders Departments of Internal Medicine, Immunology, St John's Hospital, Department of Medicine, Department of Ophthalmology, Academic Unit of Ophthalmology, Department of Oral Medicine, University Hospital, Department of Ophthalmology, Department of Rheumatology, Erasmus MC, University Medical Center, 's-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands

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.001), whereas the mean K D (95% CI) of the receptor did not differ between patients (8.34, 6.62–10.50 nM) and controls (8.46, 7.37–9.71 nM). Importantly, the EC 50 values of GILZ and IL2 and the number of GR did not differ significantly between Caucasian and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-12-0056
Volume/Issue:
Volume 1: Issue 2
Open access
Marianna Martino Division of Endocrinology and Metabolic Diseases, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, Ancona, Italy

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Paolo Falcioni Division of Endocrinology and Metabolic Diseases, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, Ancona, Italy

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Giulia Giancola Division of Endocrinology and Metabolic Diseases, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, Ancona, Italy

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Alessandro Ciarloni Division of Endocrinology and Metabolic Diseases, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, Ancona, Italy

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Gianmaria Salvio Division of Endocrinology and Metabolic Diseases, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, Ancona, Italy

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Francesca Silvetti Division of Endocrinology and Metabolic Diseases, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, Ancona, Italy

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Augusto Taccaliti Division of Endocrinology and Metabolic Diseases, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, Ancona, Italy

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Giorgio Arnaldi Division of Endocrinology and Metabolic Diseases, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, Ancona, Italy

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with more severe pneumonia, but did not find any significant differences in IL-6 levels between severe and non-severe COVID-19 pneumonia ( 34 ). If the relationship between hyponatremia and COVID-19 pneumonia is a matter of fact ( 24 , 28 , 29 , 30

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0411
Volume/Issue:
Volume 10: Issue 10
Open access
Shin-ya Ueda Department of Acupuncture, Morinomiya University of Medical Sciences, Osaka, Japan

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Hidehiro Nakahara Department of Acupuncture, Morinomiya University of Medical Sciences, Osaka, Japan

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Eriko Kawai Department of Environmental Physiology for Exercise, Osaka City University Graduate School of Medicine, Osaka, Japan

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Tatsuya Usui Department of Elementary and Preschool Education, Osaka Seikei College, Osaka, Japan

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Shintaro Tsuji Department of Elementary and Preschool Education, Osaka Seikei College, Osaka, Japan

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Tadayoshi Miyamoto Department of Acupuncture, Morinomiya University of Medical Sciences, Osaka, Japan

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.7 ± 1.6 * Walking speed (km/h) 6.6 ± 0.9 6.0 ± 0.5 ** Biochemical parameters  Glucose (mg/dL) 91.6 ± 8.1 90.4 ± 8.9 NS  Insulin (μU/mL) 3.7 ± 2.8 3.6 ± 2.4 NS  IL-6 (pg/mL) 0.45 ± 0.4 1.34 ± 0

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0323
Volume/Issue:
Volume 7: Issue 1
Open access
A Chinoy Royal Manchester Children’s Hospital, Manchester, UK

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M Skae Royal Manchester Children’s Hospital, Manchester, UK

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A Babiker King Abdullah Specialized Children’s Hospital, Riyadh, Saudi Arabia

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D Kendall Royal Preston Hospital, Preston, UK

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M Z Mughal Royal Manchester Children’s Hospital, Manchester, UK

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R Padidela Royal Manchester Children’s Hospital, Manchester, UK

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/mmol ( 2 )) demonstrated with cCa >1.9 mmol/L. Given these challenges, subcutaneous injections of teriparatide – recombinant human PTH(1–34) (rhPTH(1–34) was initiated on an off-licence basis (dose 0.4 μg/kg twice-daily)). This established acceptable cCa

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0234
Volume/Issue:
Volume 6: Issue 8
Open access
Huiyuan Zhai Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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Dongxu Wang Department of Geriatrics, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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Yong Wang Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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Hongwei Gu Central Laboratory, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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Juan Jv Department of Cardiology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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Liangliang Yuan Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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Chao Wang Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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Leiyao Chen Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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display heightened levels of circulating inflammatory markers such as tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), IL-1β, and monocyte chemoattractant protein 1 (MCP-1), as well as decreased plasma levels of anti-inflammatory cytokines

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-23-0379
Volume/Issue:
Volume 13: Issue 5
Open access
Jairo Arturo Pinzón-Cortés Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
School of Medicine, Universidad de los Andes, Bogotá, Colombia

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Angelina Perna-Chaux Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia

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Nicolás Steven Rojas-Villamizar Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia

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Angélica Díaz-Basabe Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia

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Diana Carolina Polanía-Villanueva Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia

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María Fernanda Jácome Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia

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Carlos Olimpo Mendivil School of Medicine, Universidad de los Andes, Bogotá, Colombia
Endocrinology Section, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia

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Helena Groot Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
School of Medicine, Universidad de los Andes, Bogotá, Colombia

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Valeriano López-Segura Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
School of Medicine, Universidad de los Andes, Bogotá, Colombia

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(no. of individuals) Average HbA1c (%) Average DNA methylation-5mC (ng and %) Average DNA hydroxymethylation-5hmC (ng and %) Well-controlled patients 19 48.51 ± 12.42 9.83 ± 8.09 3 0 6.06 ± 0.47 1.34 ± 0.98 ng 0

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0199
Volume/Issue:
Volume 6: Issue 8
Open access
Yao Chen Hangzhou Fuyang Women and Children Hospital, Hangzhou, China

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Shu-ying Fang Hangzhou Fuyang Women and Children Hospital, Hangzhou, China

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) C677T polymorphism, peroxisome proliferator-activated receptor gamma ( PPAR-γ ) polymorphism and interleukin-1beta/IL-1 receptor antagonist ( IL-1β/IL-1Ra ) gene polymorphisms. StAR polymorphisms Hyperandrogenism accounts for most of the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-18-0121
Volume/Issue:
Volume 7: Issue 5
Open access
Michaela Keuper Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden

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with either LPS/INFγ-activated MΦ-CM or IL10/TGFβ-activated MΦ-CM ( 34 ), using a human model system composed of SGBS cells, a human subcutaneous adipocyte model and THP1 cells, a human monocytic cell line that can be differentiated into MΦ and

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-19-0016
Volume/Issue:
Volume 8: Issue 6
Open access