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fractions of eluate (fraction 1, containing IGFBPs; fraction 2, inter-peak; fraction 3, containing IGFs and fraction 4, post-peak) were routinely collected for each acidified plasma sample, using collection times based on elution times of 125 I-IGF1 and IGF
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-Klotho). S-Klotho is a protein that has been reported to inhibit IGF1R (and insulin receptor) signaling by inhibiting tyrosine phosphorylation of both receptors and their downstream signaling proteins (i.e. IRS) (5, 6, 7) . Acromegaly is characterized by
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.1210/jc.2015-3451 ) 2 Cannata D Lann D Wu Y Elis S Sun H Yakar S Lazzarino DA Wood TL Leroith D . Elevated circulating IGF-I promotes mammary gland development and proliferation . Endocrinology 2010 151 5751 – 5761 . ( https
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Vascular Research Group, School of Community Based Medicine, Centre for Integrated Genomic Medical Research, Cardiovascular Research Group, Endocrinology and Diabetes, Salford R&D, Department of Endocrinology and Diabetes, Faculty of Medical, Human and Life Sciences, The University of Manchester, Manchester M13 9PT, UK
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Vascular Research Group, School of Community Based Medicine, Centre for Integrated Genomic Medical Research, Cardiovascular Research Group, Endocrinology and Diabetes, Salford R&D, Department of Endocrinology and Diabetes, Faculty of Medical, Human and Life Sciences, The University of Manchester, Manchester M13 9PT, UK
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roles of the GH/IGF-axis in the kidney: lessons from experimental rodent models . Growth Hormone & IGF Research 2004 14 418 – 430 . ( doi:10.1016/j.ghir.2004.06.003 ). 6 Levin-Iaina N Iaina A Raz I . The emerging role of NO and IGF-1 in
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Raphael Recanati Genetic Institute, Rabin Medical Center – Beilinson Hospital, Petach Tikva, Israel
Felsenstein Medical Research Center, Petach Tikva, Israel
Pediatric Genetics, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel
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Jesse Z. and Sara Lea Shafer Institute for Endocrinology and Diabetes, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel
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Shalom and VardaYoran Institute for Human Genome Research, Tel Aviv University, Tel Aviv, Israel
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Jesse Z. and Sara Lea Shafer Institute for Endocrinology and Diabetes, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel
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specific (genetic or other) defect can be recognized. Growth and developmental conditions under the umbrella of congenital insulin-like growth factor-1 ( IGF-1 ) deficiencies include: (i) growth hormone (GH) releasing hormone-receptor ( GHRH-R ) defect
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Department of Cardiology, Department of Growth and Reproduction, Faculty of Health Sciences, Nephrology and Endocrinology H, Hillerød University Hospital, Dyrehavevej 29, DK-3400 Hillerød, Denmark
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Department of Cardiology, Department of Growth and Reproduction, Faculty of Health Sciences, Nephrology and Endocrinology H, Hillerød University Hospital, Dyrehavevej 29, DK-3400 Hillerød, Denmark
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P Mathiesen ER . Lower levels of circulating IGF-I in type 1 diabetic women with frequent severe hypoglycaemia during pregnancy . Diabetic Medicine 2008 25 826 – 833 . ( doi:10.1111/j.1464-5491.2008.02495.x ). 6 Tan K Baxter RC . Serum
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, these data indicate that i) IGF1 activates IGF1R and INSR in both C4-2 and P69 cell lines; ii) INSR activation by IGF1 is not affected by A12 treatment (in comparison with the complete inhibition of IGF1R); and iii) downstream signaling cascades are
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Garvan Institute of Medical Research, New South Wales, Australia
School of Medical Sciences, University of New South Wales, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Department of Diabetes and Endocrinology, Westmead Hospital, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
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Faculty of Medicine, Health and Human Sciences, Macquarie University, New South Wales, Australia
Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia
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Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
Steno Diabetes Center Odense, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
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coating and for detection, and an anti-IGF-2 antibody (# I-7276, Sigma) was directly tagged with Europium according to the manufacturer’s instructions (Perkin Elmer Life Sciences) was applied. Intra-assay and inter-assay CVs were 5 and 10%, respectively
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Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
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Dipartimento di Neuroscienze, Riabilitazione, Oftalmologia, Genetica e Scienze Materno-infantili, Università di Genova, Genova, Italy
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also found significant differences in IGF1 values between the OGHD and IGHD group, with best discriminative cut-off of −2.65 SDS, confirming that patients with organic and genetic GHD (i.e. usually severe GHD) have lower IGF1 values than patients with
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.1210/edrv-16-2-143 7540132 14 Kooijman R. Regulation of apoptosis by insulin-like growth factor (IGF)-I . Cytokine and Growth Factor Reviews 2006 17 305 – 323 . ( https://doi.org/10.1016/j.cytogfr.2006.02.002 ) 10.1016/j.cytogfr.2006.02.002 15