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Yanmei Lou Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, People’s Republic of China

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Yanyan Zhang Department of Epidemiology and Health Statistics, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China

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Ping Zhao Department of Health Management, Beijing Xiaotangshan Hospital, Beijing, People’s Republic of China

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Pei Qin Department of Epidemiology and Health Statistics, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China

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Changyi Wang Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, People’s Republic of China

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Jianping Ma Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, People’s Republic of China

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Xiaolin Peng Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, People’s Republic of China

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Hongen Chen Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, People’s Republic of China

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Dan Zhao Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, People’s Republic of China

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Shan Xu Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, People’s Republic of China

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Li Wang Department of Non-communicable Disease Prevention and Control, Shenzhen Nanshan Center for Chronic Disease, Shenzhen, Guangdong, People’s Republic of China

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Ming Zhang Department of Epidemiology and Health Statistics, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China

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Dongsheng Hu Department of Epidemiology and Health Statistics, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China

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Fulan Hu Department of Epidemiology and Health Statistics, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China

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Chinese cohort. Materials and methods Participants This cohort analysis included adults aged 18–80 years who underwent a comprehensive health screening examination at Beijing Xiaotangshan Hospital between 2009 and 2016. The participants were

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Mengxue Yang Department of Endocrinology, The Fifth People’s Hospital of Shanghai, Fudan University, Shanghai, China
Department of Endocrinology, Zunyi Medical University, Zunyi, China

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Bowen Sun Department of Endocrinology, Zunyi Medical University, Zunyi, China

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Jianhui Li Department of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China

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Bo Yang Department of Endocrinology, Zunyi Medical University, Zunyi, China

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Jie Xu School of Public Health, Zunyi Medical University, Zunyi, China

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Xue Zhou Department of Endocrinology, Zunyi Medical University, Zunyi, China

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Jie Yu School of Public Health, Zunyi Medical University, Zunyi, China

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Xuan Zhang Department of Endocrinology, Zunyi Medical University, Zunyi, China

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Qun Zhang Department of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China

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Shan Zhou Department of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China

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Xiaohua Sun Department of Endocrinology, Ningbo No. 2 Hospital, Ningbo, China

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the population in China is approximately 1.2% ( 6 ). GD can lead to damage in various systems, such as the nervous system, somatosensory system and cardiovascular system and can even induce life-threatening thyroid crisis. Risk factors for GD include

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Xiaomei Zhang Department of Endocrinology, Peking University International Hospital, Beijing, China

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Zhangrong Xu Diabetes Center, Characteristic Medical Center of Strategic Support Force, Beijing, China

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Xingwu Ran Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China

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Linong Ji Department of Endocrinology, Peking University International Hospital, Beijing, China
Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, China

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increased alarmingly in China, affecting over 26 million people among adult patients with diabetes ( 6 ). Despite its burden on public health, clinicians and patients have a low level of awareness of LEAD. There is a lack of diagnosis in many patients, and

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Yijun Tang Department of Endocrinology and Metabolism, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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Yao Chen Department of Endocrinology and Metabolism, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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Jiayi Wang Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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Qianwen Zhang Department of Endocrinology and Metabolism, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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Yirou Wang Department of Endocrinology and Metabolism, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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Yufei Xu Department of Medical Genetics and Molecular Diagnostic Laboratory, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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Xin Li Department of Endocrinology and Metabolism, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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Jian Wang International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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Xiumin Wang Department of Endocrinology and Metabolism, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

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, and (iii) 46,XX DSD. The worldwide incidence of DSD is between 1/500 and 1/10,000 ( 3 ). However, there are no relevant DSD incidence statistics for the Chinese population ( 4 , 5 ). Compared with sex chromosome DSD and 46,XX DSD, 46,XY DSD patients

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Yuan Fang Department of Epidemiology, School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai, China

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Xuehong Zhang Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA

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Huilin Xu Center for Disease Control and Prevention of Minhang District, Shanghai, China

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Stephanie A Smith-Warner Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA

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Dongli Xu Center for Disease Control and Prevention of Minhang District, Shanghai, China

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Hong Fang Center for Disease Control and Prevention of Minhang District, Shanghai, China

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Wang Hong Xu Department of Epidemiology, School of Public Health and Key Laboratory of Public Health Safety, Fudan University, Shanghai, China

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, suggesting the possibility of detection bias. China ranks first in the number of individuals with prevalent T2DM worldwide ( 10 ). Multiple studies have reported an increased risk of cancer in T2DM patients in China ( 11 , 12 , 13 ), implicating an

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Xiang Hu Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Qiao Zhang Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Tian-Shu Zeng Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Jiao-Yue Zhang Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Jie Min Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Sheng-Hua Tian Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Hantao Huang Yiling Hospital, Yichang, China

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Miaomiao Peng Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Nan Zhang Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Mengjiao Li Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Qing Wan Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Fei Xiao Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Yan Chen Institute of Big Data and Internet Innovation, Hunan University of Commerce, Changsha, China

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Chaodong Wu Department of Nutrition and Food Science, Texas A&M University, College Station, Texas, USA

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Lu-Lu Chen Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Introduction Diabetes is a silent killer affecting humans, with continuing growth of incidence, prevalence, costs and death ( 1 ). It is estimated that in the Chinese adult population, the overall prevalence of diabetes is 11.6% ( 2 ) and 50

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Yuerong Yan Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

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Lili You Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

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Xiaoyi Wang Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

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Zhuo Zhang Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

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Feng Li Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

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Hongshi Wu Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

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Muchao Wu Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

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Jin Zhang Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

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Jiayun Wu Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

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Caixia Chen Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

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Xiaohui Li Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

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Biwen Xia Department of Endocrinology, The Fourth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

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Mingtong Xu Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

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Li Yan Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China

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Introduction Iodine is an essential micronutrient required by the thyroid gland to synthesize and secrete thyroid hormones ( 1 ). Iodized salt is the main supplement to iodine, and China has implemented universal salt iodization (USI) policy

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Wei Liu Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Yunke Ma Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Xiaoling Cai Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Yu Zhu Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Mingxia Zhang Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Juan Li Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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Jing Chen School of Automation, Beijing Institute of Technology, Beijing, People’s Republic of China

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Dawei Shi School of Automation, Beijing Institute of Technology, Beijing, People’s Republic of China

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Linong Ji Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, People’s Republic of China

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, the impact of these factors on blood glucose control could not be excluded. The incidence of type 1 diabetes in China is significantly lower than that in the Caucasian population, and there is no study focusing on the relationship between preserved C

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Xun Gong Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Lili You Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Feng Li Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Qingyu Chen Department of Medical Examination Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China

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Chaogang Chen Department of Clinical Nutrition, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China

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Xiaoyun Zhang Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Xiuwei Zhang Department of Endocrinology, Dongguan People’s Hospital, Dongguan, People’s Republic of China

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Wenting Xuan Department of Endocrinology, Dongguan People’s Hospital, Dongguan, People’s Republic of China

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Kan Sun Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Guojuan Lao Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Chuan Wang Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Yan Li Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Mingtong Xu Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Meng Ren Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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Li Yan Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China

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-sectional study, which included 75,880 Chinese adults showed that the prevalence of total diabetes and pre-diabetes, according to the American Diabetes Association (ADA) criteria, reached 12.8 and 35.2%, respectively ( 2 ). Moreover, 70% of patients with pre

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Li Qian Department of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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Yuxiao Zhu Department of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

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Yan Luo Department of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

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Mu Zhang Department of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

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Liping Yu Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA

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Yu Liu Department of Endocrinology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

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Tao Yang Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

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high sensitivity and specificity ( 7 ) to evaluate the prevalence of UBE2L3-Ab and eEF1A1-Ab both in Chinese Han and American Caucasian subjects with T1DM in comparison with healthy controls. Research design and methods The quantity and

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