Ping Li
Ping Li
Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
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Fei Cheng
Fei Cheng
Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
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Lei Xiu
Lei Xiu
Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
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statistic (>50%) indicated heterogeneity between studies, the random-effects model was preferred. Otherwise, the fixed-effect model was recommended. Statistical analyses were performed using RevMan 5.3 software. Risk of bias assessment Two authors (F
Nidan Qiao
Nidan Qiao
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Haixia Cheng
Haixia Cheng
Department of Pathology, Huashan Hospital, Shanghai Medical School, Shanghai, China
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Zhaoyun Zhang
Zhaoyun Zhang
Department of Endocrinology, Huashan Hospital, Shanghai Medical School, Shanghai, China
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Hongying Ye
Hongying Ye
Department of Endocrinology, Huashan Hospital, Shanghai Medical School, Shanghai, China
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Ming Shen
Ming Shen
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Xuefei Shou
Xuefei Shou
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Xiaoyun Cao
Xiaoyun Cao
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Hong Chen
Hong Chen
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
Department of Pathology, Huashan Hospital, Shanghai Medical School, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
Department of Pathology, Huashan Hospital, Shanghai Medical School, Shanghai, China
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Xiang Zhou
Xiang Zhou
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Yongfei Wang
Yongfei Wang
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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Yao Zhao
Yao Zhao
Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
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better illumination and close-up observation during transsphenoidal surgery ( 5 , 6 ). However, surgical results and complications using the endoscopic transsphenoidal approach have been seldom discussed in previous studies. Although the 2021 WHO
Jiaxin Luo
Jiaxin Luo
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Weili Yin
Weili Yin
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Qiuxia Lin
Qiuxia Lin
The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong Province, China
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Juqing Wu
Juqing Wu
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Pan Chen
Pan Chen
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Yuanna Ling
Yuanna Ling
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Jing Wang
Jing Wang
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Zhen Li
Zhen Li
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Liqin Pan
Liqin Pan
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Yanying Chen
Yanying Chen
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Wei Ouyang
Wei Ouyang
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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Huijuan Feng
Huijuan Feng
Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong Province, China
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.602–83.398 months), and the 3- and 5-year LPFS probabilities were 57.8 and 45.1%, respectively ( Fig. 2 ). Log-rank analysis ( Fig. 3 and Table 5 ) showed that the impacts of the following six variables on LPFS were statistically significant: bone metastasis as
Ashley K Clift
Ashley K Clift
Department of Surgery and Cancer, Imperial College London, London, UK
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Omar Faiz
Omar Faiz
Department of Surgery, St Mark’s Hospital, London, UK
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Robert Goldin
Robert Goldin
Centre for Pathology, Imperial College London, London, UK
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John Martin
John Martin
Department of Gastroenterology, Imperial College London, London, UK
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Harpreet Wasan
Harpreet Wasan
Department of Surgery and Cancer, Imperial College London, London, UK
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Marc-Olaf Liedke
Marc-Olaf Liedke
Department of Surgery, Westkuesten Klinikum Heide, Heide, Germany
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Erik Schloericke
Erik Schloericke
Department of Surgery, Westkuesten Klinikum Heide, Heide, Germany
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Anna Malczewska
Anna Malczewska
Department of Surgery and Cancer, Imperial College London, London, UK
Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland
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Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland
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Guido Rindi
Guido Rindi
Institute of Anatomic Pathology, Universita Cattolica del Sacro Cuore, Rome, Italy
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Mark Kidd
Mark Kidd
Wren Laboratories, Branford, Connecticut, USA
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Irvin M Modlin
Irvin M Modlin
Emeritus Professor Gastrointestinal Surgery, School of Medicine, Yale University, New Haven, Connecticut, USA
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Andrea Frilling
Andrea Frilling
Department of Surgery and Cancer, Imperial College London, London, UK
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high (>95) risk scores, respectively. Regarding the discrimination of the NET nomogram, the C-index equalled 0.65; ROC analysis demonstrated that for 5-year disease-specific survival, the AUC was 0.637 (95% CI: 0.362–0.912, P = 0.289), whereas for
Alexander Heinzel
Alexander Heinzel
RWTH University Hospital Aachen, Department of Nuclear Medicine, Aachen, Germany
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Dirk Müller
Dirk Müller
Institute for Health Economics and Clinical Epidemiology, University of Cologne, Cologne, Germany
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Hanneke M van Santen
Hanneke M van Santen
Wilhelmina Children’s Hospital, University Medical Center Utrecht, Department of Pediatric Endocrinology, Utrecht, The Netherlands
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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Sarah C Clement
Sarah C Clement
Wilhelmina Children’s Hospital, University Medical Center Utrecht, Department of Pediatric Endocrinology, Utrecht, The Netherlands
Emma Children’s Hospital, Amsterdam UMC, Department of Pediatrics, Amsterdam, The Netherlands
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Emma Children’s Hospital, Amsterdam UMC, Department of Pediatrics, Amsterdam, The Netherlands
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Arthur B Schneider
Arthur B Schneider
University of Illinois at Chicago, Department of Medicine, Chicago, IL, USA
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Frederik A Verburg
Frederik A Verburg
Erasmus MC Rotterdam, Department of Radiology & Nuclear Medicine, Rotterdam, The Netherlands
University Hospital Würzburg, Department of Nuclear Medicine, Würzburg, Germany
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University Hospital Würzburg, Department of Nuclear Medicine, Würzburg, Germany
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.4% at a tumor diameter of 1.1 cm, 4.8 ± 1.1% at 2.5 cm and 13.1 ± 2.5% at 4.1 cm. For patients without distant metastases and >18 and <45 years of age at diagnosis, 10-year survival was 98.4 ± 0.5%. For patients <45 years of age with distant metastases
Eva Olga Melin
Eva Olga Melin
Department of Clinical Sciences, Endocrinology and Diabetes, Lund University, Faculty of Medicine, Lund, Sweden
Department of Research and Development, Region Kronoberg, Växjö, Sweden
Region Kronoberg, Primary Care, Växjö, Sweden
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Department of Research and Development, Region Kronoberg, Växjö, Sweden
Region Kronoberg, Primary Care, Växjö, Sweden
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Jonatan Dereke
Jonatan Dereke
Department of Clinical Sciences Lund, Lund University, Faculty of Medicine, Diabetes Research Laboratory, Lund, Sweden
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Maria Thunander
Maria Thunander
Department of Clinical Sciences, Endocrinology and Diabetes, Lund University, Faculty of Medicine, Lund, Sweden
Department of Research and Development, Region Kronoberg, Växjö, Sweden
Department of Internal Medicine, Endocrinology and Diabetes, Central Hospital, Växjö, Sweden
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Department of Research and Development, Region Kronoberg, Växjö, Sweden
Department of Internal Medicine, Endocrinology and Diabetes, Central Hospital, Växjö, Sweden
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Magnus Hillman
Magnus Hillman
Department of Clinical Sciences Lund, Lund University, Faculty of Medicine, Diabetes Research Laboratory, Lund, Sweden
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year) 1.03 (1.00–1.06) 0.053 1.03 (1.00–1.06) 0.095 1.02 (0.98–1.06) 0.42 1.03 (0.97–1.08) 0.32 Diabetes duration (per year) 1.02 (0.99–1.05) 0.16 – – – – – – Depression (HADS-D ≥8p) 3.5 (1.5–8.0) 0
Maxime Duval
Maxime Duval
Department of Medicine, Clinique Jules Verne, Nantes, France
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Kalyane Bach-Ngohou
Kalyane Bach-Ngohou
Department of Biology, Laboratory of Clinical Biochemistry, CHU Nantes, Nantes, France
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Damien Masson
Damien Masson
Department of Biology, Laboratory of Clinical Biochemistry, CHU Nantes, Nantes, France
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Camille Guimard
Camille Guimard
Department of Emergency Medicine, CHU Nantes, Nantes, France
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Philippe Le Conte
Philippe Le Conte
Department of Emergency Medicine, CHU Nantes, Nantes, France
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David Trewick
David Trewick
Department of Medicine, Clinique Jules Verne, Nantes, France
Department of Emergency Medicine, CHU Nantes, Nantes, France
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Department of Emergency Medicine, CHU Nantes, Nantes, France
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the risk of sudden cardiac arrest (SCA) in the community ( 5 ). Calcium is a bivalent cation that is essential for a number of physiological processes that include neuromuscular activity, endocrine and exocrine secretion, coagulation, immunity and
Mette Marie Baunsgaard
Mette Marie Baunsgaard
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Anne Sophie Lind Helligsoe
Anne Sophie Lind Helligsoe
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Louise Tram Henriksen
Louise Tram Henriksen
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Torben Stamm Mikkelsen
Torben Stamm Mikkelsen
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Michael Callesen
Michael Callesen
Department of Paediatrics, Odense University Hospital, Odense, Funen, Denmark
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Britta Weber
Britta Weber
The Danish Center for Particle Therapy, Aarhus University Hospital, Aarhus, Denmark
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Henrik Hasle
Henrik Hasle
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Niels Birkebæk
Niels Birkebæk
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark
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last 5 decades ( 3 , 4 ), due to treatment improvements with targeted cranial radiotherapy (CR) in combination with chemotherapy and improved surgery techniques ( 5 ). The overall 5-year survival rate is now approaching 83% in the Nordic countries ( 6
Ann-Cathrin Koschker
Ann-Cathrin Koschker
Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
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Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
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Bodo Warrings
Bodo Warrings
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Würzburg, Würzburg, Germany
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Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Würzburg, Würzburg, Germany
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Caroline Morbach
Caroline Morbach
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Florian Seyfried
Florian Seyfried
Department of General, Visceral, Transplant, Vascular, and Pediatric Surgery, University Hospital, University of Würzburg, Würzburg, Germany
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Nicole Rickert
Nicole Rickert
Department of Radiology, University Hospital, University of Würzburg, Würzburg, Germany
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Pius Jung
Pius Jung
Division of Pneumology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Andreas Geier
Andreas Geier
Division of Hepatology, Department of Internal Medicine II, University Hospital, University of Würzburg, Würzburg, Germany
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Ulrich Dischinger
Ulrich Dischinger
Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Maike Krauthausen
Maike Krauthausen
Department of General Practice, University Hospital, University of Würzburg, Würzburg, Germany
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Martin J Herrmann
Martin J Herrmann
Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital, University of Würzburg, Würzburg, Germany
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Christine Stier
Christine Stier
Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Department of General, Visceral, Transplant, Vascular, and Pediatric Surgery, University Hospital, University of Würzburg, Würzburg, Germany
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Department of General, Visceral, Transplant, Vascular, and Pediatric Surgery, University Hospital, University of Würzburg, Würzburg, Germany
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Stefan Frantz
Stefan Frantz
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Uwe Malzahn
Uwe Malzahn
Center for Clinical Trials, University Hospital, University of Würzburg, Würzburg, Germany
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Stefan Störk
Stefan Störk
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Division of Cardiology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
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Martin Fassnacht
Martin Fassnacht
Division of Endocrinology and Diabetology, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany
Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
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Comprehensive Heart Failure Center, University & University Hospital Würzburg, Würzburg, Germany
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the WAS Study Group
the WAS Study Group
the WAS Study Group
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the risk of new-onset heart failure, particularly heart failure with preserved ejection fraction ( 4 , 5 ). Patients with morbid obesity appear to carry a significantly higher mortality risk ( 6 , 7 ). Currently, bariatric surgery is the only
Charlotte Höybye
Charlotte Höybye
Department of Endocrinology and Department of Molecular Medicine and Surgery, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden
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Beverly M K Biller
Beverly M K Biller
Neuroendocrine Unit, Massachusetts General Hospital, Massachusetts General Hospital, Boston, Massachusetts, USA
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Jean-Marc Ferran
Jean-Marc Ferran
Qualiance ApS, Copenhagen, Denmark
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Murray B Gordon
Murray B Gordon
Allegheny Neuroendocrinology Center, Division of Endocrinology, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA
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Nicky Kelepouris
Nicky Kelepouris
US Medical Affairs-Rare Endocrine Disorders, Novo Nordisk, Inc, Plainsboro, New Jersey, USA
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Navid Nedjatian
Navid Nedjatian
Global Medical Affairs – Rare Endocrine Disorders, Novo Nordisk Health Care AG, Zurich, Switzerland
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Anne H Olsen
Anne H Olsen
Epidemiology, Novo Nordisk A/S, Soborg, Denmark
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Matthias M Weber
Matthias M Weber
Unit of Endocrinology, 1, Medical Department, University Hospital, Universitätsmedizin Mainz, der Johannes Gutenberg-Universität, Mainz, Germany
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quality of life, an adverse lipid profile and an increased risk for cardiovascular (CV)-associated disease, diabetes and metabolic syndrome vs healthy adults ( 4 , 5 , 6 , 7 ). The use of growth hormone (GH) replacement therapy in AGHD has been shown
