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Jan-Bernd Stukenborg NORDFERTIL Research Lab Stockholm, Pediatric Endocrinology Unit, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, Stockholm, Sweden

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Kirsi Jahnukainen NORDFERTIL Research Lab Stockholm, Pediatric Endocrinology Unit, Department of Women’s and Children’s Health, Karolinska Institutet and University Hospital, Stockholm, Sweden
Division of Haematology-Oncology and Stem Cell Transplantation, Children’s Hospital, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland

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Marsida Hutka MRC Centre for Reproductive Health, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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Rod T Mitchell MRC Centre for Reproductive Health, The Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
Edinburgh Royal Hospital for Sick Children, Edinburgh, UK

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a result of the underlying cancer (e.g. testicular cancer) or due to the damaging effects of chemotherapy or radiotherapy ( 4 ). Treatments that directly damage the SSC population will impact on subsequent fertility; however, indirect effects on germ

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Antonella Giampietro Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy

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Sabrina Chiloiro Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy

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Claudio Urbani Endocrinology II Unit, Department of Medicine, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy

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Rosario Pivonello Dipartimento Di Medicina Clinica E Chirurgia, Sezione Di Endocrinologia, Università Federico II di Napoli, Naples, Italy

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Martin Ove Carlsson Global Medical Affairs, Pfizer Rare Disease, Brussels, Belgium

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Francesca Dassie Department of Medicine - DIMED, University of Padua, Padua, Italy

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Nunzia Prencipe Division of Endocrinology, Diabetology and Metabolism, Department of Medical Science, University of Turin, Turin, Italy

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Marta Ragonese Unit of Endocrinology, Department of Human Pathology, University of Messina, Messina, Italy

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Roy Gomez Global Medical Affairs, Pfizer Rare Disease, Brussels, Belgium

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Simona Granato Medical Department, Pfizer Italia, Rome, Italy

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Salvatore Cannavò Unit of Endocrinology, Department of Human Pathology, University of Messina, Messina, Italy

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Silvia Grottoli Division of Endocrinology, Diabetology and Metabolism, Department of Medical Science, University of Turin, Turin, Italy

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Pietro Maffei Department of Medicine - DIMED, University of Padua, Padua, Italy

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Annamaria Colao Dipartimento Di Medicina Clinica E Chirurgia, Sezione Di Endocrinologia, Università Federico II di Napoli, Naples, Italy

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Fausto Bogazzi Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

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Antonio Bianchi Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy

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(GH)-secreting pituitary tumor that increases GH and insulin-like growth factor 1 (IGF-1) secretion ( 2 ). The primary aim of the treatment – through neurosurgery, radiotherapy or pharmacological therapy – is to achieve disease control by normalizing

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Judith Gebauer Department of Internal Medicine I, University Hospital Schleswig-Holstein, Luebeck, Germany

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Claire E Higham Department of Endocrinology, Christie Hospital NHS Foundation Trust, University of Manchester, and Manchester Academic Health Science Centre, Manchester, UK

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specialists. Topics will cover bone health, growth hormone deficiency, the impact of different radiotherapy techniques on the hypothalamic–pituitary axis, risk assessment for second cancers, as well as strategies for international collaboration and different

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Deborah Cosentini Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy

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Salvatore Grisanti Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy

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Alberto Dalla Volta Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy

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Marta Laganà Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy

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Chiara Fiorentini Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

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Paola Perotti Internal Medicine, Department of Clinical and Biological Sciences, San Luigi Hospital, University of Turin, Orbassano, Italy

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Sandra Sigala Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

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Alfredo Berruti Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili, Brescia, Italy

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predisposing condition of response to immunotherapy. Moreover, there is an increasing interest in combining chemotherapy, radiotherapy or molecular target therapies with immunotherapy ( 28 , 29 ) and of course also agents inhibiting steroid synthesis may have

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C Chiapponi Department of General, Visceral, Cancer and Transplant Surgery, University Hospital of Cologne, Cologne, Germany

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H Alakus Department of General, Visceral, Cancer and Transplant Surgery, University Hospital of Cologne, Cologne, Germany

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M Faust Polyclinic for Endocrinology, Diabetes and Preventive Medicine, University Hospital of Cologne, Cologne, Germany

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A M Schultheis Department of Pathology, University Hospital of Cologne, Cologne, Germany

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J Rosenbrock Department of Radiation Therapy, University Hospital of Cologne, Cologne, Germany

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M Schmidt Department of Nuclear Medicine, Faculty of Medicine, University Hospital of Cologne, Cologne, Germany

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repeated surgery or after R1 removal of metastases, in order to reduce the risk of recurrence. The ETA Guidelines ( 8 ) state that 'although RAI-R thyroid carcinomas are not very sensitive to radiation, external beam radiotherapy (EBRT) may be indicated in

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Dan Liang Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Han Chen Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Li-Yong Zhong Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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response to chemotherapy or radiotherapy; (ii) the pre-treatment brain images indicating a sellar lesion; and (iii) the completion of the multidisciplinary treatment for iGCT. The exclusion criteria were (i) a history of chromosomal abnormalities or other

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Stefan M Constantinescu Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Brussels, Belgium

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Thierry Duprez Department of Radiology, Cliniques Universitaires Saint-Luc, Brussels, Belgium

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Edward Fomekong Department of Neurosurgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium

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Christian Raftopoulos Department of Neurosurgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium

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Orsalia Alexopoulou Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Brussels, Belgium

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Dominique Maiter Department of Endocrinology and Nutrition, Cliniques Universitaires Saint-Luc, Brussels, Belgium

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treated with conventional fractionated radiotherapy because of contraindications to surgery. The six other patients elected to remain under surveillance because the growth was moderate (mean of 4 mm during the follow-up period) and did not provoke any new

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Jung Soo Lim Department of Internal Medicine, Institute of Evidence-Based Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do, South Korea

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Seung-Eun Lee Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, South Korea

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Jung Hee Kim Department of Internal Medicine, Seoul National University College of Medicine, Jongno-gu, Seoul, South Korea

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Jae Hyeon Kim Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, South Korea

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The Korean Adrenal Gland and Endocrine Hypertension Study Group, Korean Endocrine Society
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included in the survey to determine therapeutic and adverse outcomes in a Korean ACC patient cohort. Although ACC was previously considered a radiotherapy-resistant disease, and there were contradictory results of adjuvant radiotherapy ( 47 , 48 ), recent

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Emmanuelle Motte UFR des Sciences de la Santé, Simone Veil, Université Versailles St-Quentin en Yvelines, Montigny le Bretonneux, France
Assistance Publique Hôpitaux de Paris (APHP), Department of Endocrinology and Diabetes for Children, Bicêtre Paris-Sud, Le Kremlin Bicêtre, France

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Anya Rothenbuhler Assistance Publique Hôpitaux de Paris (APHP), Department of Endocrinology and Diabetes for Children, Bicêtre Paris-Sud, Le Kremlin Bicêtre, France
APHP, Plateforme d’Expertise Maladies Rares Paris Sud, Bicêtre Paris Sud Hospital, Le Kremlin Bicêtre, France

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Stephan Gaillard Department of Neurosurgery, Foch Hospital, Suresnes, France

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Najiba Lahlou APHP, Department of Hormonal Biology, Cochin Hospital, Paris, France

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Cécile Teinturier Assistance Publique Hôpitaux de Paris (APHP), Department of Endocrinology and Diabetes for Children, Bicêtre Paris-Sud, Le Kremlin Bicêtre, France
APHP, Plateforme d’Expertise Maladies Rares Paris Sud, Bicêtre Paris Sud Hospital, Le Kremlin Bicêtre, France

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Régis Coutant Department of Pediatric Endocrinology, Angers University Hospital, Angers, France

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Agnès Linglart Assistance Publique Hôpitaux de Paris (APHP), Department of Endocrinology and Diabetes for Children, Bicêtre Paris-Sud, Le Kremlin Bicêtre, France
APHP, Plateforme d’Expertise Maladies Rares Paris Sud, Bicêtre Paris Sud Hospital, Le Kremlin Bicêtre, France

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, 15 , 16 ), prompting physicians to use alternative therapies such as pituitary radiotherapy or adrenolytic agents. O,p’-dichlorodiphenyldichloroethane (mitotane, Lysodren 500 mg; HRA Pharma, Paris, France) is an adrenolytic drug with a direct

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Eva Jakobsson Ung Institute of Health and Care Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Centre for Person-Centred Care (GPCC), University of Gothenburg, Gothenburg, Sweden
Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden

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Ann-Charlotte Olofsson Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden

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Ida Björkman Institute of Health and Care Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Centre for Person-Centred Care (GPCC), University of Gothenburg, Gothenburg, Sweden

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Tobias Hallén Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden
Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden

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Daniel S Olsson Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Oskar Ragnarsson Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Thomas Skoglund Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden
Institute of Neuroscience and Physiology, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden

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Sofie Jakobsson Institute of Health and Care Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
Centre for Person-Centred Care (GPCC), University of Gothenburg, Gothenburg, Sweden

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Gudmundur Johannsson Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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also, sometimes, radiotherapy ( 4 , 5 ). The tumours and/or its treatment are associated with excess mortality and morbidity ( 3 , 6 , 7 , 8 , 9 ). The consequences of both the tumour and surgery and/or radiotherapy may lead to hypopituitarism and

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