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Nidan Qiao

into the potential advantages of endoscopic TS for patients with CD, especially with respect to endocrine outcomes, we conducted a systematic review and meta-analysis to evaluate studies of endoscopic TS and microscopic TS. Method Study search

Open access

Ali Abbasi

until April 2015. The overview of this systematic literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, when applicable (12) . A manual search was also done for the

Open access

Cheng Han Ng, Yip Han Chin, Marcus Hon Qin Tan, Jun Xuan Ng, Samantha Peiling Yang, Jolene Jiayu Kiew and Chin Meng Khoo

Purpose: Primary hyperparathyroidism (PHPT) is common condition, affecting people of all ages and is mainly treated with parathyroidectomy. Cinacalcet has been widely used in secondary or tertiary hyperparathyroidism, but the use of cinacalcet in PHPT is less clear.

Methods: Searches were conducted in Medline and Embase for cinacalcet use in PHPT from induction to 10th April 2020. Articles and conferences abstracts describing the use of cinacalcet for PHPT in prospective or retrospective cohorts and randomized controlled trials restricted to English Language only. We initially identified 1301 abstracts. Each article went extraction by two blinded authors on a structured proforma. Continuous outcomes were pooled with weight mean difference (WMD). Quality of included articles was assessed with Newcastle Ottwa Scale and Cochrane risk of Bias 2.0.

Results: 28 articles were included. Normalization rate of serum calcium levels was reported at 90% (CI: 0.82 to 0.96). Serum levels of calcium and PTH levels were significantly reduced (calcium, WMD: 1.647 (CI: -1.922 to -1.371; PTH, WMD: -31.218, CI: -41.671 to -20.765) and phosphate levels significantly increased (WMD: 0.498, CI: 0.400 to 0.596) after cinacalcet therapy The higher the baseline calcium levels, the greater calcium reduction with cinacalcet treatment. Age and gender did not modify the effect of cinacalcet on serum calcium levels.

Conclusion: The results from the meta-analysis support the use of cinacalcet as an alternative or bridging therapy to treat hypercalcemia in people with PHPT.

Open access

Daiki Kobayashi, Nagato Kuriyama, Keita Hirano, Osamu Takahashi and Hiroshi Noto

study. First, our data contained only diabetes treatment status, so the types of medication were unknown. Certain medications, such as pioglitazone or metformin, may cause or prevent cancer ( 38 , 39 ). A recent meta-analysis reported that pioglitazone

Open access

Katica Bajuk Studen and Marija Pfeifer

development of hypertension, cardiovascular disease and abnormalities in glucose metabolism ( 43 , 44 , 45 ). A recent meta-analysis suggests that risk of OSA is increased in adult women with PCOS. It seems that central obesity, hyperandrogenemia and insulin

Open access

Yao Chen and Shu-ying Fang

investigated in PCOS patients until now. Relevant literatures of case–control researches and meta-analysis studies were searched from PubMed database or by citation search and reference lists of relevant articles. Relationships of the candidate genes with PCOS

Open access

Luminita Nicoleta Cima, Anca Colita and Simona Fica

.94–2.82 CI, confidence interval; DFS, disease-free survival; OR, odds ratio; POF, premature ovarian failure; PR, pregnancy rate; RCT, randomized clinical trials; RM, resumption of menses; RR, relative risk. The largest meta-analysis that provides

Open access

Raymond J Rodgers, Jodie C Avery, Vivienne M Moore, Michael J Davies, Ricardo Azziz, Elisabet Stener-Victorin, Lisa J Moran, Sarah A Robertson, Nigel K Stepto, Robert J Norman and Helena J Teede

clamp techniques showed that 75% of lean and 95% of obese women had IR compared to weight-matched controls ( 17 ). This was supported by a meta-analysis of clamp studies in PCOS where IR is clearly increased independently of BMI, yet, it is exacerbated

Open access

Philippe Thuillier, Nathalie Roudaut, Geneviève Crouzeix, Marie Cavarec, Philippe Robin, Ronan Abgral, Véronique Kerlan and Pierre-Yves Salaun

, explorations have to be discussed. In FDG PET–CT, TI may appear as a focal FDG uptake (fTI) or as diffuse thyroid uptake (dTI) of the thyroid parenchyma. A recent meta-analysis of thirty studies, mostly retrospective, found a prevalence of 1.6% and 2.1% for fTI

Open access

Thozhukat Sathyapalan, Anne-Marie Coady, Eric S Kilpatrick and Stephen L Atkin

J Peto R Armitage J Baigent C. Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis . Lancet 2008 371 117 – 125 . ( doi:10.1016/S0140-6736(08)60104-X