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Jan W Eriksson Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Reem A Emad Department of Pharmacy, Uppsala University, Uppsala, Sweden

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Martin H Lundqvist Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Niclas Abrahamsson Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Maria C Kjellsson Department of Pharmacy, Uppsala University, Uppsala, Sweden

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Introduction Development of type 2 diabetes has been perceived as a process that involves progressive insulin resistance in muscles, adipose tissue, and liver and a gradual failure of pancreatic beta cells to secrete sufficient amounts of

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-22-0506
Volume/Issue:
Volume 12: Issue 4
Open access
Li Li Department of Endocrinology and Metabolism, Ningbo First Hospital, Ningbo, Zhejiang, China

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Qifa Song Department of Microbiology, Ningbo Municipal Centre for Disease Control and Prevention, Ningbo, Zhejiang, China

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Xi Yang Department of Endocrinology and Metabolism, Ningbo First Hospital, Ningbo, Zhejiang, China

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Introduction In the past 40 years, a dramatic increase in the overweight and obese population has been seen globally. The potential adverse effects of obesity include insulin resistance and possible insufficient insulin secretion due to the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0476
Volume/Issue:
Volume 9: Issue 2
Open access
Yansu Wang Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China

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Yun Shen Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China

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Tingting Hu Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China

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Yufei Wang Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China

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Xiaojing Ma Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China

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Haoyong Yu Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China

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Yuqian Bao Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China

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. Thus, the purpose of this study was to investigate the association between serum clusterin levels and NAFLD in the Chinese population. In addition, due to the tight relationship between insulin resistance and clusterin ( 20 ), a mediation analysis would

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-22-0545
Volume/Issue:
Volume 12: Issue 7
Open access
Karim Gariani Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Geneva University Hospitals and Geneva University, Geneva, Switzerland

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François R Jornayvaz Service of Endocrinology, Diabetes, Nutrition and Therapeutic Patient Education, Geneva University Hospitals and Geneva University, Geneva, Switzerland
Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland

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risk factors to develop NAFLD and NASH are the presence of insulin resistance and obesity. However, NAFLD and NASH are associated with other extrahepatic manifestations, adding to the burden of disease. These manifestations notably include obstructive

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0490
Volume/Issue:
Volume 10: Issue 2
Open access
Yumei Zhai The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia Autonomous Region, P.R. China

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Haiming Fu Department of Clinical Laboratory, Baotou Maternal and Child Health Center, Baotou, Inner Mongolia Autonomous Region, P.R. China

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Yu Li The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia Autonomous Region, P.R. China

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Siyuan Li The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia Autonomous Region, P.R. China

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Wenchen Zhang The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia Autonomous Region, P.R. China

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Jianwei Yue The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia Autonomous Region, P.R. China

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Zichao Wang The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia Autonomous Region, P.R. China

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crucial to mitigate associated disabilities and fatalities ( 5 ). Insulin resistance (IR) is a central factor in cardiovascular diseases ( 6 ). In hypertensive patients, IR not only exacerbates hypertension but also contributes to hypertension

Article Type:
Research Article
Collections:
Cardiovascular
DOI:
https://doi.org/10.1530/EC-23-0476
Volume/Issue:
Volume 13: Issue 4
Open access
Nicolás Crisosto Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Santiago, Chile

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Bárbara Echiburú Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Santiago, Chile

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Manuel Maliqueo Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Santiago, Chile

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Marta Luchsinger Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Santiago, Chile

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Pedro Rojas Laboratory of Animal Physiology and Endocrinology, Faculty of Veterinary Sciences, University of Concepción, Chillán, Chile

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Sergio Recabarren Laboratory of Animal Physiology and Endocrinology, Faculty of Veterinary Sciences, University of Concepción, Chillán, Chile

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Teresa Sir-Petermann Endocrinology and Metabolism Laboratory, West Division, School of Medicine, University of Chile, Santiago, Chile

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groups ( 14 ). Regarding metabolic features, we observed increased weight from an early age and some indicators of insulin resistance during adulthood ( 12 ). Puberty is a transition period between childhood and adulthood accompanied by profound changes

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0218
Volume/Issue:
Volume 6: Issue 8
Open access
Pernille H Hellmann Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Jonatan I Bagger Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark

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Katrine R Carlander Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

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Katrine B Hansen Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark

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Julie L Forman Section of Biostatistics, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Joachim Størling Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark

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Elizaveta Chabanova Department of Radiology, Herlev Hospital, University of Copenhagen, Herlev, Denmark

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Jens Holst Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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Tina Vilsbøll Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark

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Filip K Knop Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

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that expression of 2% of our genome is regulated by glucocorticoids ( 5 ). Prednisolone is known to induce insulin resistance, increased hepatic glucose production, hyperglycaemia and secondary diabetes. Even lean, healthy individuals can experience

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-22-0334
Volume/Issue:
Volume 12: Issue 4
Open access
Thozhukat Sathyapalan Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, UK

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Anne-Marie Coady Department of Obstetric Ultrasound, Hull and East Yorkshire Women’s and Children’s Hospital, Hull, UK

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Eric S Kilpatrick Department of Clinical Biochemistry, Sidra Medical and Research Center, Doha, Qatar

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Stephen L Atkin Department of Medicine, Weill Cornell Medical College, Doha, Qatar

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reduction in insulin resistance especially with weight loss in patients with T2DM will result in normalisation of pancreatic β-cell requirement and even reversal of T2DM ( 9 ). Statins have shown to improve certain features of polycystic ovary syndrome

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0217
Volume/Issue:
Volume 6: Issue 8
Open access
Melinda Kertész Department of Medicine and Nephrology-Diabetes Centre, Medical School, University of Pécs, Pécs, Baranya, Hungary

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Szilárd Kun Department of Medicine and Nephrology-Diabetes Centre, Medical School, University of Pécs, Pécs, Baranya, Hungary

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Eszter Sélley Department of Medicine and Nephrology-Diabetes Centre, Medical School, University of Pécs, Pécs, Baranya, Hungary

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Zsuzsanna Nagy Department of Medicine and Nephrology-Diabetes Centre, Medical School, University of Pécs, Pécs, Baranya, Hungary

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Tamás Kőszegi Department of Laboratory Medicine, Medical School, University of Pécs, Pécs, Baranya, Hungary

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István Wittmann Department of Medicine and Nephrology-Diabetes Centre, Medical School, University of Pécs, Pécs, Baranya, Hungary

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Introduction Insulin resistance related to glucotoxicity and lipotoxicity is a well-described phenomenon ( 1 , 2 ). It is also known that in insulin-resistant patients other hormonal resistance may occur (e.g. resistance to leptin and FSH ( 3

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0218
Volume/Issue:
Volume 10: Issue 7
Open access
Jia Liu Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Chaoyang District, Beijing, China

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Lin Zhang Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Chaoyang District, Beijing, China

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Jing Fu Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Chaoyang District, Beijing, China

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Qiu Wang Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Chaoyang District, Beijing, China

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Guang Wang Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Chaoyang District, Beijing, China

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increased insulin sensitivity and regulated glucose and lipid metabolism in rodent models ( 10 , 11 , 12 ). PRL receptor knockout caused insulin resistance and severe adipose tissue dysfunction in obese mice ( 10 ). Many population-based studies found that

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0040
Volume/Issue:
Volume 10: Issue 4
Open access