Boju Pan
Boju Pan
Department of Pathology, Molecular Pathology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Anqi Wang
Anqi Wang
Clinical Biobank, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Junyi Pang
Junyi Pang
Department of Pathology, Molecular Pathology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Yuhan Zhang
Yuhan Zhang
Department of Pathology, Molecular Pathology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Ming Cui
Ming Cui
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Jian Sun
Jian Sun
Department of Pathology, Molecular Pathology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Zhiyong Liang
Zhiyong Liang
Department of Pathology, Molecular Pathology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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recognition as foreign and thus escape attack by the immune system ( 1 ). Indeed, PD-L1 expression levels have been correlated with clinical outcome ( 1 ). Additionally, as the development of PD-1 inhibitors to treat malignancies has progressed, a series of
C E Higham
C E Higham
Department of Endocrinology, Christie Hospital NHS Foundation Trust, Manchester, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
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A Olsson-Brown
A Olsson-Brown
The Clatterbridge Cancer Centre, Bebbington, Wirral, UK
The University of Liverpool, Brownlow Hill, Liverpool, UK
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The University of Liverpool, Brownlow Hill, Liverpool, UK
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P Carroll
P Carroll
Department of Endocrinology, Guy’s & St. Thomas’ NHS Foundation Trust, London, UK
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T Cooksley
T Cooksley
Department of Acute Medicine, UHSM and Christie Hospital NHS Foundation Trust, Manchester, UK
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J Larkin
J Larkin
Skin Unit, Royal Marsden Hospital, London, UK
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P Lorigan
P Lorigan
Department of Medical Oncology, Christie Hospital NHS Foundation Trust, Manchester, UK
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D Morganstein
D Morganstein
Department of Endocrinology, Chelsea and Westminster Hospital, London, UK
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P J Trainer
P J Trainer
Department of Endocrinology, Christie Hospital NHS Foundation Trust, Manchester, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
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the Society for Endocrinology Clinical Committee
the Society for Endocrinology Clinical Committee
The Society for Endocrinology, Starling House, 1600 Bristol Parkway North, Bristol, UK
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by immune-mediated adverse effects particularly with combination treatment ( 3 , 4 , 5 , 6 ). Immune-mediated endocrinopathies as a consequence of treatment with checkpoint inhibitors include hypophysitis, adrenalitis, thyroiditis and diabetes
Elizabeth Yan Zhang
Elizabeth Yan Zhang
Department of Pharmacology, Department of Biology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Room 4061 of KLSIC Building, 2146 West 39th Street, Kansas City, Kansas 66160, USA
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Bao-Ting Zhu
Bao-Ting Zhu
Department of Pharmacology, Department of Biology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Room 4061 of KLSIC Building, 2146 West 39th Street, Kansas City, Kansas 66160, USA
Department of Pharmacology, Department of Biology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Room 4061 of KLSIC Building, 2146 West 39th Street, Kansas City, Kansas 66160, USA
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Department of Pharmacology, Department of Biology, Toxicology and Therapeutics, School of Medicine, University of Kansas Medical Center, Room 4061 of KLSIC Building, 2146 West 39th Street, Kansas City, Kansas 66160, USA
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Introduction Many earlier studies have shown that estrogens are important modulators of immune system functions. It was demonstrated that although physiological levels of estrogens are immunostimulatory, high or super-physiological levels of
Peter Ergang
Peter Ergang
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
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Anna Mikulecká
Anna Mikulecká
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
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Martin Vodicˇka
Martin Vodicˇka
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic
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Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic
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Karla Vagnerová
Karla Vagnerová
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
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Ivan Mikšík
Ivan Mikšík
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
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Jirˇí Pácha
Jirˇí Pácha
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic
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Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic
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the sympathetic–adrenal–medullary axis, which subsequently release glucocorticoids and catecholamines, respectively. The HPA and SNS axes are the two major pathways through which stress is able to modulate immune functions depending on the nature
Cecília Cristelo
Cecília Cristelo
i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
CEB – Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal
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CEB – Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal
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Alexandra Machado
Alexandra Machado
CEB – Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal
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Bruno Sarmento
Bruno Sarmento
i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde & Instituto Universitário de Ciências da Saúde, Gandra, Portugal
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CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde & Instituto Universitário de Ciências da Saúde, Gandra, Portugal
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Francisco Miguel Gama
Francisco Miguel Gama
CEB – Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal
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the kidneys ( 30 ), which then acts to maintain serum calcium levels, although its activities go beyond calcium homeostasis and bone metabolism ( 31 ). The vitamin D receptor (VDR) has been identified in practically all immune cell types ( 32
Yongping Liu
Yongping Liu
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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Shuo Wang
Shuo Wang
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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Qingling Guo
Qingling Guo
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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Yongze Li
Yongze Li
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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Jing Qin
Jing Qin
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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Na Zhao
Na Zhao
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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Yushu Li
Yushu Li
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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Zhongyan Shan
Zhongyan Shan
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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Weiping Teng
Weiping Teng
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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), tumourigenesis ( 20 ) and immune cell regulation ( 21 ). However, the role of sub-family V in the immune response is still unclear. Semaphorin 5A (Sema 5A), one of the sub-family V of semaphorins, contains a specific seven-repeat domain of thrombospondin in its
Athanasios D Anastasilakis
Athanasios D Anastasilakis
Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Greece
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Marina Tsoli
Marina Tsoli
1st Propaedeutic Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Gregory Kaltsas
Gregory Kaltsas
1st Propaedeutic Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece
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Polyzois Makras
Polyzois Makras
Department of Endocrinology and Diabetes, 251 Hellenic Air Force & VA General Hospital, Athens, Greece
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interaction between the skeletal and immune system has long been recognized since the two systems share a lot of regulatory mechanisms including cytokines, signaling molecules, receptors and transcription factors ( 28 ). Osteoclasts are multinucleated cells
Nancy J Olsen
Nancy J Olsen
Division of Rheumatology, Division of Endocrinology, Diabetes, and Metabolism, College of Medicine, Milton S Hershey Medical Center, The Pennsylvania State University, Mail Code H044, 500 University Drive, Hershey, Pennsylvania 17033-0850, USA
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Ann L Benko
Ann L Benko
Division of Rheumatology, Division of Endocrinology, Diabetes, and Metabolism, College of Medicine, Milton S Hershey Medical Center, The Pennsylvania State University, Mail Code H044, 500 University Drive, Hershey, Pennsylvania 17033-0850, USA
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William J Kovacs
William J Kovacs
Division of Rheumatology, Division of Endocrinology, Diabetes, and Metabolism, College of Medicine, Milton S Hershey Medical Center, The Pennsylvania State University, Mail Code H044, 500 University Drive, Hershey, Pennsylvania 17033-0850, USA
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of endogenous androgens, inherited variation in sensitivity to these hormones might play an even more significant role in modulation of immune reactivity when compared with men. We genotyped a cohort of women with lupus for variation at the AR exon
Camila Aparecida Moma
Camila Aparecida Moma
Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil
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Icléia Siqueira Barreto
Icléia Siqueira Barreto
Department of Pathology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil
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Ligia Vera Montali Assumpção
Ligia Vera Montali Assumpção
Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil
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Denise Engelbrecht Zantut-Wittmann
Denise Engelbrecht Zantut-Wittmann
Endocrinology Division, Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil
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tumor microenvironment, which allows us to understand how the immune system orchestrates itself to contain neoplastic progression ( 10 , 11 , 12 , 13 , 14 ). Initially, neoplastic cells are identified and destroyed by the immune system; however
Weiwei Liang
Weiwei Liang
Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
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Yilin Zhang
Yilin Zhang
Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
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Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
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Yan Guo
Yan Guo
Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
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Pengyuan Zhang
Pengyuan Zhang
Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
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Jiewen Jin
Jiewen Jin
Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
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Hongyu Guan
Hongyu Guan
Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
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Yanbing Li
Yanbing Li
Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
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temperature, the protein bands were visualized using enzyme-linked chemiluminescence detection (ECL) Kit (Beyotime Biotechnology, Beijing, China). Correlation analysis of FLNA and tumor immune microenvironment The correlation between FLNA and tumor
