Xiao-jun Zhou
Xiao-jun Zhou
Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China
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Lin Ding
Lin Ding
Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China
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Jia-xin Liu
Jia-xin Liu
Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China
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Le-qun Su
Le-qun Su
Department of Pharmacy, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China
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Jian-jun Dong
Jian-jun Dong
Division of Endocrinology, Department of Medicine, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, China
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Lin Liao
Lin Liao
Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China
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glycemic control remains around 50% in the United States ( 3 ) and 39.7% in China ( 4 ). Dipeptidyl peptidase-4 (DPP-4) inhibitors, characterized by low propensity of hypoglycemia and weight neutrality, have gradually become an important class in the
M Jensterle
M Jensterle
Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia
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A Podbregar
A Podbregar
University Rehabilitation Institute Republic of Slovenia, Ljubljana, Slovenia
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K Goricar
K Goricar
University of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Pharmacogenetics Laboratory, Ljubljana, Slovenia
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N Gregoric
N Gregoric
Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia
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A Janez
A Janez
Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia
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weight lost as well as its role after a trail of unsuccessful LSM is unclear. Only few studies to date reported that combination of TRT and LSM is superior to LSM alone in increasing insulin sensitivity, glycemic control, muscle mass and reducing liver
Hoda Gad
Hoda Gad
Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar
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Einas Elgassim
Einas Elgassim
Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar
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Ibrahim Mohammed
Ibrahim Mohammed
Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar
Department of Internal Medicine, Albany Medical Center Hospital, Albany, New York, USA
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Department of Internal Medicine, Albany Medical Center Hospital, Albany, New York, USA
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Ahmad Yaser Alhaddad
Ahmad Yaser Alhaddad
Department of Mechanical and Industrial Engineering, Qatar University, Doha, Qatar
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Hussein Ahmed Hussein Zaky Aly
Hussein Ahmed Hussein Zaky Aly
KINDI Center for computing research, Qatar University, Doha, Qatar
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John-John Cabibihan
John-John Cabibihan
Department of Mechanical and Industrial Engineering, Qatar University, Doha, Qatar
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Abdulaziz Al-Ali
Abdulaziz Al-Ali
KINDI Center for computing research, Qatar University, Doha, Qatar
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Kishor Kumar Sadasivuni
Kishor Kumar Sadasivuni
Center for Advanced Materials, Qatar University, Doha, Qatar
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Aliyaa Haji
Aliyaa Haji
Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar
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Neila Lamine
Neila Lamine
Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar
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Adnan Khan
Adnan Khan
Faculty of Healthy Sciences, Khyber Medical University, Peshawar, Pakistan
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Ioannis N Petropoulos
Ioannis N Petropoulos
Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar
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Georgios Ponirakis
Georgios Ponirakis
Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar
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Alise Kalteniece
Alise Kalteniece
Institute of Cardiovascular Medicine, University of Manchester, Manchester, UK
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Maryam Ferdousi
Maryam Ferdousi
Institute of Cardiovascular Medicine, University of Manchester, Manchester, UK
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Shazli Azmi
Shazli Azmi
Institute of Cardiovascular Medicine, University of Manchester, Manchester, UK
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Uazman Alam
Uazman Alam
Diabetes and Neuropathy Research, Department of Eye and Vision Sciences and Pain Research Institute, Institute of Ageing and Chronic Disease, University of Liverpool and Aintree University Hospital NHS Foundation Trust, Liverpool, UK
Department of Diabetes and Endocrinology, Royal Liverpool and Broadgreen University NHS Hospital Trust, Liverpool, UK
Division of Endocrinology, Diabetes and Gastroenterology, University of Manchester, Manchester, UK
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Department of Diabetes and Endocrinology, Royal Liverpool and Broadgreen University NHS Hospital Trust, Liverpool, UK
Division of Endocrinology, Diabetes and Gastroenterology, University of Manchester, Manchester, UK
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Wajeeha Abuhelaiqa
Wajeeha Abuhelaiqa
Hamad Medical Corporation, National Diabetes Center, Doha, Qatar
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Amin Jayyousi
Amin Jayyousi
Hamad Medical Corporation, National Diabetes Center, Doha, Qatar
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Dabia AlMohanadi
Dabia AlMohanadi
Hamad Medical Corporation, National Diabetes Center, Doha, Qatar
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Khaled Baagar
Khaled Baagar
Hamad Medical Corporation, National Diabetes Center, Doha, Qatar
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Rayaz A Malik
Rayaz A Malik
Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar
Institute of Cardiovascular Medicine, University of Manchester, Manchester, UK
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Institute of Cardiovascular Medicine, University of Manchester, Manchester, UK
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lower limb amputation ( 1 ). Recognized risk factors for DPN include poor glycemic control, obesity, hypertension and dyslipidemia ( 3 , 4 ). However, HbA1c provides limited insight into the short-term variations in blood glucose, which may affect nerve
M Boering
M Boering
Isala, Diabetes Centre, Zwolle, The Netherlands
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P R van Dijk
P R van Dijk
Isala, Diabetes Centre, Zwolle, The Netherlands
Isala, Department of Internal Medicine, Zwolle, The Netherlands
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Isala, Department of Internal Medicine, Zwolle, The Netherlands
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S J J Logtenberg
S J J Logtenberg
Diakonessenhuis, Department of Internal Medicine, Utrecht, The Netherlands
Langerhans Medical Research group, Zwolle, The Netherlands
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Langerhans Medical Research group, Zwolle, The Netherlands
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K H Groenier
K H Groenier
Isala, Diabetes Centre, Zwolle, The Netherlands
Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Department of General Practice, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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B H R Wolffenbuttel
B H R Wolffenbuttel
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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R O B Gans
R O B Gans
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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N Kleefstra
N Kleefstra
Isala, Diabetes Centre, Zwolle, The Netherlands
Langerhans Medical Research group, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Langerhans Medical Research group, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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H J G Bilo
H J G Bilo
Isala, Diabetes Centre, Zwolle, The Netherlands
Isala, Department of Internal Medicine, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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Isala, Department of Internal Medicine, Zwolle, The Netherlands
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
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randomized, open-label crossover trial that was carried out in a single center (Isala, Zwolle, the Netherlands) ( 23 ). The aim of this crossover trial was to investigate the influence of CIPII versus SC insulin treatment on glycemic control and hypoglycemic
Tsung-Hui Wu
Tsung-Hui Wu
Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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Guan-Yu Su
Guan-Yu Su
Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
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Tsung-Yun Liu
Tsung-Yun Liu
Institute of Food Safety and Health Risk Assessment, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan
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Hsiang-Tsui Wang
Hsiang-Tsui Wang
Institute of Food Safety and Health Risk Assessment, College of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan
Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
PhD Program in Toxicology, Kaohsiung Medical University, Kaohsiung, Taiwan
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Institute of Pharmacology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
PhD Program in Toxicology, Kaohsiung Medical University, Kaohsiung, Taiwan
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Chii-Min Hwu
Chii-Min Hwu
Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
Faculty of Medicine, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan
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Faculty of Medicine, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan
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fibers causes muscle weakness and sensory disturbances, and small fiber involvement is characterized by neuropathic pain, impaired temperature sensation, and autonomic dysfunction ( 2 ). While poor glycemic control and cardiovascular risk factors have
Annalisa Blasetti
Annalisa Blasetti
Department of Paediatrics, University of Chieti, Chieti, Italy
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Valeria Castorani
Valeria Castorani
Department of Paediatrics, University of Chieti, Chieti, Italy
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Nella Polidori
Nella Polidori
Department of Paediatrics, University of Chieti, Chieti, Italy
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Ilaria Mascioli
Ilaria Mascioli
Department of Paediatrics, University of Chieti, Chieti, Italy
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Francesco Chiarelli
Francesco Chiarelli
Department of Paediatrics, University of Chieti, Chieti, Italy
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Cosimo Giannini
Cosimo Giannini
Department of Paediatrics, University of Chieti, Chieti, Italy
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Introduction Type 1 diabetes (T1D) and other chronic diseases are well recognized to adversely affect linear growth in childhood. Indeed, early studies have shown that suboptimal glycemic control and longer disease duration can impair
Yongli Fu
Yongli Fu
Department of Endocrinology, The Second Affiliated Hospital of Qiqihar Medical College, Qiqihar, Heilongjiang Province, People’s Republic of China
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Yaowu Sun
Yaowu Sun
Higher Education Research and Teaching Quality Assessment Center, Qiqihar Medical College, Qiqihar, Heilongjiang Province, People’s Republic of China
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Jiankun Zhang
Jiankun Zhang
Department of Clinical Laboratory, The Second Affiliated Hospital of Qiqihar Medical College, Qiqihar, Heilongjiang Province, People’s Republic of China
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Yu Cheng
Yu Cheng
Department of Nutrition and Food Hygiene, School of Public Health, Qiqihar Medical College, Qiqihar, Heilongjiang Province, People’s Republic of China
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Introduction The past two decades have witnessed great progress on the research regarding optimal glycemic control strategy for critically ill patients based on several randomized controlled trials (RCTs). However, there are still debates on
Emmanuel K Fai
Emmanuel K Fai
University of Maryland Medical Center Midtown Campus, Baltimore, Maryland, USA
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Cheryl Anderson
Cheryl Anderson
Walden University, Minneapolis, Minnesota, USA
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Victor Ferreros
Victor Ferreros
Walden University, Minneapolis, Minnesota, USA
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, 6 ). Type 2 diabetes mellitus is a common chronic disease. Adherence to needed drug regimens is important for individuals with type 2 diabetes. Inadequate adherence to the use of medical therapies results in poor glycemic control and thus increase
W Liu
W Liu
Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, China
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Y Wang
Y Wang
Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, China
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X Han
X Han
Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, China
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X Cai
X Cai
Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, China
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Y Zhu
Y Zhu
Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, China
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M Zhang
M Zhang
Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, China
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S Gong
S Gong
Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, China
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J Li
J Li
Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, China
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L Ji
L Ji
Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing, China
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marital status were also associated with better glycemic control. ( 16 ) Socioeconomic status correlates with the level of self-management skills, such as the frequency of self-monitoring of blood glucose (SMBG) measurements, the timing of the meal bolus
Jairo Arturo Pinzón-Cortés
Jairo Arturo Pinzón-Cortés
Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
School of Medicine, Universidad de los Andes, Bogotá, Colombia
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School of Medicine, Universidad de los Andes, Bogotá, Colombia
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Angelina Perna-Chaux
Angelina Perna-Chaux
Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
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Nicolás Steven Rojas-Villamizar
Nicolás Steven Rojas-Villamizar
Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
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Angélica Díaz-Basabe
Angélica Díaz-Basabe
Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
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Diana Carolina Polanía-Villanueva
Diana Carolina Polanía-Villanueva
Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
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María Fernanda Jácome
María Fernanda Jácome
Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
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Carlos Olimpo Mendivil
Carlos Olimpo Mendivil
School of Medicine, Universidad de los Andes, Bogotá, Colombia
Endocrinology Section, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia
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Endocrinology Section, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá, Colombia
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Helena Groot
Helena Groot
Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
School of Medicine, Universidad de los Andes, Bogotá, Colombia
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School of Medicine, Universidad de los Andes, Bogotá, Colombia
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Valeriano López-Segura
Valeriano López-Segura
Biological Sciences Department, Laboratory of Human Genetics, Universidad de los Andes, Bogotá, Colombia
School of Medicine, Universidad de los Andes, Bogotá, Colombia
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School of Medicine, Universidad de los Andes, Bogotá, Colombia
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this end, we quantitated the global levels of 5mC and 5hmC in the peripheral blood of patients with T2DM with good or poor glycemic control and then compared them to those of healthy controls. In addition, we analyzed the expression of three of the most
