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Kamran Iqbal Shire, London, UK

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Kate Halsby pH Associates, Marlow, UK

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Robert D Murray Leeds Centre for Diabetes & Endocrinology, St James’s University Hospital, Leeds, UK

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Paul V Carroll Department of Endocrinology, Guy’s & St. Thomas’ NHS Foundation Trust, London, UK

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Robert Petermann Shire, Vienna, Austria

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primary AI, a mineralocorticoid analogue (fludrocortisone), with the aim to replace the missing cortisol and aldosterone, respectively. Conventional immediate-release (IR) HC does not replicate the physiological circadian rhythm of endogenous cortisol

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0418
Volume/Issue:
Volume 8: Issue 1
Open access
Jan W Eriksson Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Reem A Emad Department of Pharmacy, Uppsala University, Uppsala, Sweden

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Martin H Lundqvist Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Niclas Abrahamsson Department of Medical Sciences, Uppsala University, Uppsala, Sweden

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Maria C Kjellsson Department of Pharmacy, Uppsala University, Uppsala, Sweden

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, 17 , 20 ). The model diversity illustrated this phenomenon. It is, however, reassuring that the main model structure of the final model was similar to other published models ( 16 ), with the main differences being the lack of circadian rhythm ( 16

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-22-0506
Volume/Issue:
Volume 12: Issue 4
Open access
Karim Gariani Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospitals, Geneva, Switzerland

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Pedro Marques-Vidal Departments of Medicine and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland

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Gérard Waeber Departments of Medicine and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland

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Peter Vollenweider Departments of Medicine and Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland

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François R Jornayvaz Service of Endocrinology, Diabetes, Hypertension and Nutrition, Geneva University Hospitals, Geneva, Switzerland

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number of diabetes complications ( 19 ). Cortisol secretion follows a circadian rhythm with a nadir at midnight, starts to rise at 02:00–04:00 h, displays a peak briefly after waking up and then shows a progressive decrease during the day ( 20 ). The

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0251
Volume/Issue:
Volume 8: Issue 7
Open access
Dan Liang Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Han Chen Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Li-Yong Zhong Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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–pituitary–adrenal axis (HPA): basal cortisol level <3 μg/dL indicated impaired HPA function while the basal cortisol level >15 μg/dL excluded it. If basal cortisol levels ranged from 3 to 15 μg/dL, the circadian rhythm of adrenocorticotropic hormone and cortisol (08

Article Type:
Research Article
Collections:
Pituitary and Hypothalamus
DOI:
https://doi.org/10.1530/EC-23-0168
Volume/Issue:
Volume 12: Issue 8
Open access
Angelica Amorim Amato Department of Pharmaceutical Sciences, University of Brasilia, Brasilia, Brazil
Department of Developmental and Cell Biology, University of California, Irvine, California, USA

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Hailey Brit Wheeler Department of Developmental and Cell Biology, University of California, Irvine, California, USA

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Bruce Blumberg Department of Developmental and Cell Biology, University of California, Irvine, California, USA
Department of Pharmaceutical Sciences, University of California, Irvine, California, USA
Department of Biomedical Engineering, University of California, Irvine, California, USA

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, 17 ). These include stress ( 18 ), disrupted circadian rhythms ( 19 ), the composition of the gut microbiome (bacterial diversity, balance of bacterial types and the particular species found) ( 20 , 21 ), air pollution from proximity to highways ( 22

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0578
Volume/Issue:
Volume 10: Issue 2
Open access
Britt J van Keulen Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands
Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands

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Michelle Romijn Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands
Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands

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Bibian van der Voorn Department of Pediatric Endocrinology, Sophia Kinderziekenhuis, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

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Marita de Waard Emma Children’s Hospital, Amsterdam University Medical Centers, locations AMC and VUmc, Amsterdam, The Netherlands

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Michaela F Hartmann Steroid Research and Mass Spectrometry Unit, Laboratory for Translational Hormone Analytics, Pediatric Endocrinology & Diabetology, Center of Child and Adolescent Medicine, Justus-Liebig-University, Giessen, Germany

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Johannes B van Goudoever Emma Children’s Hospital, Amsterdam University Medical Centers, locations AMC and VUmc, Amsterdam, The Netherlands

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Stefan A Wudy Steroid Research and Mass Spectrometry Unit, Laboratory for Translational Hormone Analytics, Pediatric Endocrinology & Diabetology, Center of Child and Adolescent Medicine, Justus-Liebig-University, Giessen, Germany

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Joost Rotteveel Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands

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Martijn J J Finken Department of Pediatric Endocrinology, Emma Children’s Hospital, Amsterdam University Medical Centers, location VUmc, Amsterdam, The Netherlands
Department of Pediatrics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Reproduction & Development Research Institute, de Boelelaan, Amsterdam, The Netherlands

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had no information on the timing of antenatal corticosteroid treatment. Finally, for practical reasons related to the NICU setting we were not able to collect 24-h urine. However, young infants have not yet developed an adult-like circadian rhythm ( 29

Article Type:
Research Article
Collections:
Paediatric Endocrinology Collection
DOI:
https://doi.org/10.1530/EC-20-0587
Volume/Issue:
Volume 10: Issue 2
Open access
Sirazum Choudhury Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Commonwealth Building, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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Tricia Tan Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Commonwealth Building, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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Katharine Lazarus Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Commonwealth Building, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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Karim Meeran Endocrinology and Investigative Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Commonwealth Building, London, UK
Department of Endocrinology, Imperial College Healthcare NHS Trust, London, UK

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. Epub 2015 May 1 150005 . ( https://doi.org/10.1530/EDM-15-0005 ) 37 Williams EL Choudhury S Tan T Meeran K Prednisolone replacement therapy mimics the circadian rhythm more closely Than other glucocorticoids . Journal of Applied Laboratory

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0473
Volume/Issue:
Volume 10: Issue 2
Open access
Filippo Ceccato Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Elisa Selmin Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Chiara Sabbadin Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Miriam Dalla Costa Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Giorgia Antonelli Laboratory Medicine, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Mario Plebani Laboratory Medicine, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Mattia Barbot Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Corrado Betterle Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Marco Boscaro Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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Carla Scaroni Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Padova, Italy

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administered in two or three divided doses (the higher in the morning), as suggested in recent Consensus and Guidelines ( 2 , 6 ). Nevertheless, none of the proposed regimen is currently able to replicate the physiological cortisol circadian rhythm

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-18-0257
Volume/Issue:
Volume 7: Issue 9
Open access
Maria Angela D'amico Section of Human Morphology, Department of Medicine and Aging Sciences, G. d'Annunzio University of Chieti–Pescara, Via Dei Vestini 31, 66013 Chieti, Italy

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Barbara Ghinassi Section of Human Morphology, Department of Medicine and Aging Sciences, G. d'Annunzio University of Chieti–Pescara, Via Dei Vestini 31, 66013 Chieti, Italy

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Pascal Izzicupo Section of Human Morphology, Department of Medicine and Aging Sciences, G. d'Annunzio University of Chieti–Pescara, Via Dei Vestini 31, 66013 Chieti, Italy

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Lamberto Manzoli Section of Human Morphology, Department of Medicine and Aging Sciences, G. d'Annunzio University of Chieti–Pescara, Via Dei Vestini 31, 66013 Chieti, Italy

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A Di Baldassarre Section of Human Morphology, Department of Medicine and Aging Sciences, G. d'Annunzio University of Chieti–Pescara, Via Dei Vestini 31, 66013 Chieti, Italy

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and salivary CgA have different routes of secretion: indeed, salivary CgA peaks upon awakening and then quickly decreases to nadir after 1 h and is maintained at a low level throughout the day, whereas plasma CgA did not show any circadian rhythm (84

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-14-0027
Volume/Issue:
Volume 3: Issue 2
Open access
Gareth Leng Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, UK

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the circadian rhythms of behaviour that persist in constant darkness. In lesioned hamsters, circadian rhythmicity can be restored by transplanting fragments of neonatal suprachiasmatic nucleus into the third ventricle – and, remarkably, can do so even

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-18-0367
Volume/Issue:
Volume 7: Issue 12
Open access