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T L C Wolters Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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C D C C van der Heijden Division of Experimental Internal Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
Division of Vascular Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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N van Leeuwen Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

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B T P Hijmans-Kersten Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

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M G Netea Division of Experimental Internal Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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J W A Smit Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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D H J Thijssen Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK

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A R M M Hermus Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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N P Riksen Division of Vascular Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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R T Netea-Maier Division of Endocrinology, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands

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). Intriguingly, immune cells express GH and IGF1 receptors ( 16 , 17 ). Previously, we found that IGF1 can impact on monocyte inflammatory function in vitro ( 18 ). Moreover, exposure to IGF1 induces trained immunity ( 19 ). However, studies on the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0430
Volume/Issue:
Volume 8: Issue 12
Open access
Antonia Ertelt Equine Clinic, Free University of Berlin, Berlin, Germany

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Ann-Kristin Barton Equine Clinic, Free University of Berlin, Berlin, Germany

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Robert R Schmitz Equine Clinic, Free University of Berlin, Berlin, Germany

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Heidrun Gehlen Equine Clinic, Free University of Berlin, Berlin, Germany

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proliferation and tissue growth and repair, might be another key in the pathogenesis of laminitis (126) . Gene expression for IGF1 receptor (IGF1R) and insulin receptor were decreased by 13- to 32-fold during a prolonged euglycemic, hyperinsulinemic clamp test

Article Type:
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DOI:
https://doi.org/10.1530/EC-14-0038
Volume/Issue:
Volume 3: Issue 3
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Athanasios Zervas Endocrine Unit, Athens Medical Centre, Athens, Greece

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George Chrousos Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, University Research Institute of Maternal and Child Health and Precision Medicine, and UNESCO Chair on Adolescent Health Care, National and Kapodistrian University of Athens, Athens, Greece
National and Kapodistrian University of Athens Medical School, ‘Aghia Sophia’ Children’s Hospital, Athens, Greece

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Sarantis Livadas Endocrine Unit, Athens Medical Centre, Athens, Greece

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, including IGF-1R heterozygous mutations or haploinsufficiency of the IGF-1 receptor gene. However, in these patients, clinodactyly, micrognathia, and a high-arched palate are observed, accompanied by severe hypoglycemic episodes ( 50 ). These features are

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-20-0615
Volume/Issue:
Volume 10: Issue 5
Open access
Xu-Ting Song Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, College of Animal Science and Technology

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Jia-Nan Zhang Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, College of Animal Science and Technology

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Duo-Wei Zhao Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, College of Animal Science and Technology

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Yu-Fei Zhai Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, College of Animal Science and Technology

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Qi Lu Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, College of Animal Science and Technology

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Mei-Yu Qi Institute of Animal Husbandry, Heilongjiang Academy of Agricultural Sciences, Harbin, China

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Ming-Hai Lu Department of Animal Science, Heilongjiang State Farms Science Technology Vocational College, Harbin, China

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Shou-Long Deng CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China

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Hong-Bing Han Beijing Key Laboratory of Animal Genetic Improvement, China Agricultural University, Beijing, China

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Xiu-Qin Yang Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, College of Animal Science and Technology

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Yu-Chang Yao Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province, College of Animal Science and Technology

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corresponding to different IGF1 transcripts across multi-species could ensure stable binding to IGF1 receptors. Although IGF1 is thought to exert its biological actions predominantly through the mature peptide, diverse biological activities have been reported

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0181
Volume/Issue:
Volume 10: Issue 9
Open access
Eric Seidel Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Nephrology and Medical Intensive Care, BCRT – Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany
Berlin Institute of Health (BIH), Berlin, Germany
Department of Nephrology, School of Medicine, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany

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Gudrun Walenda Department of Nephrology, School of Medicine, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany

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Clemens Messerschmidt Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Core Unit Bioinformatics, Berlin Institute of Health, Berlin, Germany

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Benedikt Obermayer Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
Core Unit Bioinformatics, Berlin Institute of Health, Berlin, Germany

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Mirko Peitzsch Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Paal Wallace Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Rohini Bahethi Department of Nephrology, School of Medicine, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany

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Taekyeong Yoo Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea

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Murim Choi Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea

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Petra Schrade Charité – Universitaetsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institut für Vegetative Anatomie, Berlin, Germany

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Sebastian Bachmann Charité – Universitaetsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institut für Vegetative Anatomie, Berlin, Germany

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Gerhard Liebisch Institute of Clinical Chemistry and Laboratory Medicine, Regensburg University Hospital, Regensburg, Germany

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Graeme Eisenhofer Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

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Dieter Beule Core Unit Bioinformatics, Berlin Institute of Health, Berlin, Germany
Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

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Ute I Scholl Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Nephrology and Medical Intensive Care, BCRT – Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany
Berlin Institute of Health (BIH), Berlin, Germany
Department of Nephrology, School of Medicine, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany

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Wilhelm D , Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice . PLoS Genetics 2013 e1003160 . ( https://doi.org/10.1371/journal.pgen.1003160 ) 29 Fassnacht M Libe R Kroiss M

Article Type:
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DOI:
https://doi.org/10.1530/EC-19-0510
Volume/Issue:
Volume 9: Issue 2
Open access
Sumana Chatterjee Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK

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Emily Cottrell Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK

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Stephen J Rose Birmingham Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

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Talat Mushtaq The Leeds Teaching Hospital NHS Trust, Leeds, UK

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Avinaash V Maharaj Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK

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Jack Williams Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK

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Martin O Savage Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK

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Louise A Metherell Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK

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Helen L Storr Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK

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Duyvenvoorde HA Oostdijk W Hokken-Koelega ACS Kant SG Losekoot M. Phenotypic features and response to GH treatment of patients with a molecular defect of the IGF-1 receptor . Journal of Clinical Endocrinology and Metabolism 2019 104 3157

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0026
Volume/Issue:
Volume 9: Issue 3
Open access
Nannan Bian Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Xiaomeng Sun Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Biao Zhou Departments of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China

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Lin Zhang Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Qiu Wang Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Yu An Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Xiaohui Li Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Yinhui Li Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Jia Liu Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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Hua Meng Departments of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China

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Guang Wang Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

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M Kobilka BK . Structure and dynamics of GPCR signaling complexes . Nature Structural and Molecular Biology 2018 25 4 – 12 . ( https://doi.org/10.1038/s41594-017-0011-7 ) 39 Krieger CC Neumann S Gershengorn MC . TSH/IGF1 receptor

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DOI:
https://doi.org/10.1530/EC-21-0360
Volume/Issue:
Volume 10: Issue 10
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Danielle Christine Maria van der Kaay Erasmus University Medical Center, Department of Pediatrics, Subdivision of Endocrinology, Rotterdam, Netherlands

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Anne Rochtus Department of Pediatric Endocrinology, University Hospitals Leuven, Leuven, Belgium

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Gerhard Binder University Children’s Hospital, Pediatric Endocrinology, University of Tübingen, Tübingen, Germany

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Ingo Kurth Institute of Human Genetics, Medical Faculty, RWTH Aachen University, Aachen, Germany

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Dirk Prawitt Center for Paediatrics and Adolescent Medicine, University Medical Center, Mainz, Germany

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Irène Netchine Sorbonne Université, Centre de Recherche Saint-Antoine, INSERM, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France

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Gudmundur Johannsson Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Endocrinology at Sahlgrenska University Hospital, Gothenburg, Sweden

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Anita C S Hokken-Koelega Erasmus University Medical Center, Department of Pediatrics, Subdivision of Endocrinology, Rotterdam, Netherlands

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Miriam Elbracht Institute of Human Genetics, Medical Faculty, RWTH Aachen University, Aachen, Germany

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Thomas Eggermann Institute of Human Genetics, Medical Faculty, RWTH Aachen University, Aachen, Germany

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SG Losekoot M . Phenotypic features and response to GH treatment of patients with a molecular defect of the IGF-1 receptor . Journal of Clinical Endocrinology and Metabolism 2019 104 3157 – 3171 . ( https://doi.org/10.1210/jc.2018-02065 ) 30

Article Type:
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Collections:
Paediatric Endocrinology
DOI:
https://doi.org/10.1530/EC-22-0277
Volume/Issue:
Volume 11: Issue 11
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Jakub Supronik Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland

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Małgorzata Szelachowska Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland

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Adam Kretowski Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland

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Katarzyna Siewko Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland

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.10.002 ) 20 Krieger CC Place RF Bevilacqua C Marcus-Samuels B Abel BS Skarulis MC Kahaly GJ Neumann S Gershengorn MC . TSH/IGF-1 receptor cross talk in Graves’ ophthalmopathy pathogenesis . Journal of Clinical Endocrinology and Metabolism

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Collections:
Thyroid
DOI:
https://doi.org/10.1530/EC-22-0303
Volume/Issue:
Volume 11: Issue 12
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Zhou Zheng Department of Medical Laboratory, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University, Shenzhen, Guangdong, China

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Xiuming Zhang Department of Medical Laboratory, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University, Shenzhen, Guangdong, China

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Fanggui Wu Department of Reproductive Medicine, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University, Shenzhen, Guangdong, China

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Haizhen Liao Department of Reproductive Medicine, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University, Shenzhen, Guangdong, China

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Huan Zhao Department of Reproductive Medicine, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University, Shenzhen, Guangdong, China

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Minqi Zhang Department of Reproductive Medicine, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University, Shenzhen, Guangdong, China

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Shangjie Liu Department of Reproductive Medicine, The Affiliated Luohu Hospital of Shenzhen University, Shenzhen University, Shenzhen, Guangdong, China

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can increase free androgens by inhibiting the synthesis of hepatic sex hormone-binding proteins or by binding to the insulin-like growth factor 1 (IGF-1) receptor, resulting in hyperandrogenemia ( 44 ). Given that elevated androgens in serum or ovary

Article Type:
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Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-23-0105
Volume/Issue:
Volume 13: Issue 3
Open access