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Małgorzata Kałużna Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland

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Agnieszka Nomejko Institute of Psychology, Faculty of Pedagogical and Historical Sciences, University of Wrocław, Wrocław, Poland

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Aleksandra Słowińska Institute of Psychology, Faculty of Pedagogical and Historical Sciences, University of Wrocław, Wrocław, Poland

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Katarzyna Wachowiak-Ochmańska Endocrinology, Metabolism and Internal Diseases Ward, Heliodor Swiecicki University Hospital, Poznan, Poland

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Katarzyna Pikosz Department of Pharmacognosy, Poznan University of Medical Sciences, Poznan, Poland

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Katarzyna Ziemnicka Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland

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Marek Ruchała Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland

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often observed in PCOS women ( 4 , 5 , 6 ). Irregular menstrual cycles, hirsutism, acne, and infertility may aggravate stress and psychological disorders ( 7 , 8 ). PCOS patients deal with biopsychosocial changes that may affect sexual functioning

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Milou Cecilia Madsen Department of Internal Medicine and Center of Expertise on Gender Dysphoria, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands

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Martin den Heijer Department of Internal Medicine and Center of Expertise on Gender Dysphoria, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands

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Claudia Pees Walaeus Library, Leiden University Medical Center, Leiden, the Netherlands

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Nienke R Biermasz Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands

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Leontine E H Bakker Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands

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concentrations in serum in the morning on at least two occasions (<10.4 nmol/L) ( 2 , 3 ). Low androgen levels cause morbidity and affect health-related quality of life (HR-QoL) due to infertility, decrease of sexual functions, muscle mass, strength and vitality

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Roberto Cosimo Melcangi Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy

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Livio Casarini Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy

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Marco Marino Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy

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Daniele Santi Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy

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Samantha Sperduti Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy

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Silvia Giatti Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy

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Silvia Diviccaro Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy

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Maria Grimoldi Neurology Division, Papa Giovanni XXIII Hospital, Bergamo, Italy

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Donatella Caruso Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy

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Guido Cavaletti Experimental Neurology Unit and Milan Center for Neuroscience, School of Medicine and Surgery, University of Milano Bicocca, Monza, Italy

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Manuela Simoni Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy
Center for Genomic Research, University of Modena and Reggio Emilia, Modena, Italy
Department of Medical Specialties, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy

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, chronic fatigue, joint pain and muscular ache ( 18 , 24 , 25 , 26 ). These various symptoms amount to the so-called post-finasteride syndrome (PFS). Two recent clinical studies objectivated impaired sexual function and major depression in PSF patients

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Luminita Nicoleta Cima Carol Davila University of Medicine and Pharmacy, Bucharest, Romania

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Anca Colita Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Hematology Department, Fundeni Hospital, Bucharest, Romania

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Simona Fica Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
Endocrine Department, Elias Hospital, Bucharest, Romania

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following HSCT results in a spectrum of gonadal function with varied clinical outcomes ( 5 ). Ovarian failure after HSCT has been observed in 65–84% of transplant recipients ( 5 , 12 , 13 , 14 ). In patients performing HSCT for hematological malignancies

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Stine Linding Andersen Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

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Louise Knøsgaard Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

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Aase Handberg Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

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Peter Vestergaard Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark
Steno Diabetes Center North Jutland, Aalborg University Hospital, Aalborg, Denmark

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Stig Andersen Department of Clinical Medicine, Aalborg University, Aalborg, Denmark
Department of Geriatrics, Aalborg University Hospital, Aalborg, Denmark

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Introduction Maternal thyroid function in early pregnancy is a debated matter ( 1 , 2 ). The role of thyroid hormones in fetal brain development has long drawn ample attention to the potential adverse consequences of abnormal maternal thyroid

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Rajae Talbi Department of Medicine, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

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Victor M Navarro Department of Medicine, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

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sexual behavior, pubertal timing and ovulation – at least in mice ( 15 , 16 ). Reproductive function is energy costly and requires a threshold of energy reserves, as situations of negative energy balance (e.g. anorexia nervosa) or excessive energy

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Jin Kyu Oh Department of Urology, College of Medicine, Gachon University, Incheon, Republic of Korea

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Young Jae Im Department of Urology, College of Medicine, Seoul National University, Seoul, Republic of Korea

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Kwanjin Park Department of Urology, College of Medicine, Seoul National University, Seoul, Republic of Korea

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Jae-Seung Paick Department of Urology, College of Medicine, Seoul National University, Seoul, Republic of Korea

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: regulation of corpus cavernosum structure and function . Journal of Sexual Medicine 2005 2 759 – 770 . ( https://doi.org/10.1111/j.1743-6109.2005.00094.x ) 10.1111/j.1743-6109.2005.00094.x 17 Okumu LA Braden TD Vail K Simon L Goyal HO. Low androgen

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Rafaella Sales de Freitas Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil

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Thiago F A França Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil

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Sabine Pompeia Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil

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, function, and potential molecular mechanisms of kisspeptin/KISS1R in the peripheral reproductive system can also contribute to our general knowledge of typical sexually dimorphic patterns of pubertal development. However, progress in this area will also

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Rui-yi Tang Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China

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Rong Chen Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China

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Miao Ma Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China

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Shou-qing Lin Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China

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Yi-wen Zhang Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China

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Ya-ping Wang Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People’s Republic of China

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, including deafness, renal abnormalities and digital anomalies ( 1 , 2 ). Furthermore, IHH can be categorized according to olfactory function as IHH with a normal sense of smell (normosmic IHH; nIHH) and IHH with anosmia/hyposmia (Kallmann syndrome; KS

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Kerry V Fanson Wildlife Reproductive Centre, School of Life and Environmental Sciences, School of Agriculture and Food Sciences, Taronga Conservation Society Australia, Dubbo, New South Wales, Australia
Wildlife Reproductive Centre, School of Life and Environmental Sciences, School of Agriculture and Food Sciences, Taronga Conservation Society Australia, Dubbo, New South Wales, Australia

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Tamara Keeley Wildlife Reproductive Centre, School of Life and Environmental Sciences, School of Agriculture and Food Sciences, Taronga Conservation Society Australia, Dubbo, New South Wales, Australia
Wildlife Reproductive Centre, School of Life and Environmental Sciences, School of Agriculture and Food Sciences, Taronga Conservation Society Australia, Dubbo, New South Wales, Australia

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Benjamin G Fanson Wildlife Reproductive Centre, School of Life and Environmental Sciences, School of Agriculture and Food Sciences, Taronga Conservation Society Australia, Dubbo, New South Wales, Australia

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critical role in the promotion of healthy reproductive function (reviewed in (2, 3, 4, 5) ). Elevations in GCs during proestrus have been shown to promote receptive behavior, stimulate gonadotropins, facilitate ovulation, and reduce damage caused by

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