Rachel Forfar
Rachel Forfar
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Mashal Hussain
Mashal Hussain
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK
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Puneet Khurana
Puneet Khurana
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Jennifer Cook
Jennifer Cook
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Steve Lewis
Steve Lewis
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Dillon Popat
Dillon Popat
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK
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David Jackson
David Jackson
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK
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Ed McIver
Ed McIver
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Jeff Jerman
Jeff Jerman
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Debra Taylor
Debra Taylor
Centre for Therapeutics Discovery, LifeArc, Accelerator Building, Open Innovation Campus, Stevenage, UK
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Adrian JL Clark
Adrian JL Clark
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK
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Li F Chan
Li F Chan
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK
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1-24 was purchased from Cambridge Research Biochemicals (Cleveland, UK). Homogeneous time-resolved fluorescence (HTRF) cAMP dynamic 2 assay kits were from Cisbio (Codolet, France). Progesterone ELISA kit was purchased from Cayman Chemical. GeneBLAzer
Sonja Kunz
Sonja Kunz
Department of Medicine IV, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
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Xiao Wang
Xiao Wang
Department of Medicine IV, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
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Uta Ferrari
Uta Ferrari
Department of Medicine IV, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
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Michael Drey
Michael Drey
Department of Medicine IV, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
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Marily Theodoropoulou
Marily Theodoropoulou
Department of Medicine IV, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
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Katharina Schilbach
Katharina Schilbach
Department of Medicine IV, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
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Martin Reincke
Martin Reincke
Department of Medicine IV, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
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Margit Heier
Margit Heier
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
KORA Study Centre, University Hospital of Augsburg, Augsburg, Augsburg, Germany
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KORA Study Centre, University Hospital of Augsburg, Augsburg, Augsburg, Germany
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Annette Peters
Annette Peters
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
German Centre for Cardiovascular Research (DZHK), Partner site Munich Heart Alliance, Munich, Germany
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German Centre for Cardiovascular Research (DZHK), Partner site Munich Heart Alliance, Munich, Germany
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Wolfgang Koenig
Wolfgang Koenig
German Centre for Cardiovascular Research (DZHK), Partner site Munich Heart Alliance, Munich, Germany
German Heart Centre Munich, Technical University of Munich, Munich, Germany
Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany
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German Heart Centre Munich, Technical University of Munich, Munich, Germany
Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany
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Tanja Zeller
Tanja Zeller
Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany
German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
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German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany
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Barbara Thorand
Barbara Thorand
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
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Martin Bidlingmaier
Martin Bidlingmaier
Department of Medicine IV, University Hospital, Ludwig Maximilian University Munich, Munich, Germany
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transitions. According to the manufacturer, all calibrators and QCs are traceable to certified reference materials, or, if not available for certain steroid, to primary standards. For cortisol, progesterone and testosterone NIST 971 reference material is used
T P Parikh
T P Parikh
Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, Maryland, USA
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B Stolze
B Stolze
Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA
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Y Ozarda
Y Ozarda
Department of Medical Biochemistry, Faculty of Medicine, Uludag University, Bursa, Turkey
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J Jonklaas
J Jonklaas
Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, District of Columbia, USA
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K Welsh
K Welsh
Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA
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L Masika
L Masika
Department of Laboratory Medicine and Pathology/National Health Laboratory Service Walter Sisulu University, Mthatha, South Africa
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M Hill
M Hill
Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, Maryland, USA
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A DeCherney
A DeCherney
Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, Maryland, USA
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S J Soldin
S J Soldin
Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA
Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, District of Columbia, USA
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Division of Endocrinology and Metabolism, Department of Medicine, Georgetown University, Washington, District of Columbia, USA
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or downstream hormones within the steroid synthesis pathway ( 4 , 5 , 6 ). A recent preliminary study comparing 8 AM and midnight samples on a small cohort of controls, suggests that significant diurnal variation in all but progesterone probably
María J Gómora
María J Gómora
Departamento de Embriología, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, Mexico
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Flavia Morales-Vásquez
Flavia Morales-Vásquez
Departamento de Oncología Médica, Instituto Nacional de Cancerología, Secretaría de Salud de México, CdMx, Mexico
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Enrique Pedernera
Enrique Pedernera
Departamento de Embriología, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, Mexico
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Delia Perez-Montiel
Delia Perez-Montiel
Departamento de Patología, Instituto Nacional de Cancerología, Secretaría de Salud de México, CdMx, Mexico
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Horacio López-Basave
Horacio López-Basave
Departamento de Cirugía Oncológica, Instituto Nacional de Cancerología, Secretaría de Salud de México, CdMx, Mexico
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Antonio R Villa
Antonio R Villa
División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, Mexico
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Azucena Hernández-Martínez
Azucena Hernández-Martínez
Hospital Militar de Especialidades de la Mujer y Neonatología, Secretaría de la Defensa Nacional, CdMx, Mexico
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Esteban Mena
Esteban Mena
Unidad de Apoyo Académico, Secretaría General, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, Mexico
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Carmen Mendez
Carmen Mendez
Departamento de Embriología, Facultad de Medicina, Universidad Nacional Autónoma de México, CdMx, Mexico
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migration and invasiveness, which are essential in tumor progression ( 11 , 12 , 13 , 14 ). The presence of androgen receptor (AR), estrogen receptor alpha (ER) and progesterone receptor (PR) plays an important role in the progression and treatment of
Jana Ernst
Jana Ernst
Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse, Halle (Saale), Germany
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Katharina Gert
Katharina Gert
Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse, Halle (Saale), Germany
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Frank Bernhard Kraus
Frank Bernhard Kraus
Central Laboratory, University Hospital Halle (Saale), Ernst-Grube-Strasse, Halle (Saale), Germany
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Ulrike Elisabeth Rolle-Kampczyk
Ulrike Elisabeth Rolle-Kampczyk
Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany
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Martin Wabitsch
Martin Wabitsch
Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
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Faramarz Dehghani
Faramarz Dehghani
Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse, Halle (Saale), Germany
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Kristina Schaedlich
Kristina Schaedlich
Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Grosse Steinstrasse, Halle (Saale), Germany
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-hydroxy steroid dehydrogenase 5; HSD3B , 3beta-hydroxysteroid dehydrogenase; PGR , progesterone receptor; TBP, TATA-box-binding protein. Hormone assays Cell supernatants were collected and concentrations of the adipokines leptin (high
Yao Ye
Yao Ye
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Aurelia Vattai
Aurelia Vattai
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Nina Ditsch
Nina Ditsch
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Christina Kuhn
Christina Kuhn
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Martina Rahmeh
Martina Rahmeh
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Sven Mahner
Sven Mahner
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Myriam Ripphahn
Myriam Ripphahn
Walter Brendel Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians University of Munich, Munich, Germany
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Roland Immler
Roland Immler
Walter Brendel Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians University of Munich, Munich, Germany
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Markus Sperandio
Markus Sperandio
Walter Brendel Centre of Experimental Medicine, Department of Cardiovascular Physiology and Pathophysiology, Biomedical Center, Ludwig-Maximilians University of Munich, Munich, Germany
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Udo Jeschke
Udo Jeschke
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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Viktoria von Schönfeldt
Viktoria von Schönfeldt
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany
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(FCS, Gibco). Cells were seeded into 24-well plates for the determination of beta-hCG, progesterone and PAI-1 and 6-well plates for Western blotting. After 6–8 h, cell culture medium was replaced with fresh RPMI1640 with stimulation chemicals for the
Panagiotis Anagnostis
Panagiotis Anagnostis
Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
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Irene Lambrinoudaki
Irene Lambrinoudaki
2nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Medical School, Athens, Greece
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John C Stevenson
John C Stevenson
National Heart and Lung Institute, Imperial College London, Royal Brompton and Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
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Dimitrios G Goulis
Dimitrios G Goulis
Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
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attenuate this effect, whereas low-dose norethisterone acetate and dydrogesterone are neutral ( 7 ). In general, micronized progesterone or dydrogesterone are the preferred progestogens due to their neutral effect on lipid profile ( 39 ). MHT and CVD
Paal Methlie
Paal Methlie
Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
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Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
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Steinar Hustad
Steinar Hustad
Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
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Ralf Kellman
Ralf Kellman
Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
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Bjørg Almås
Bjørg Almås
Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
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Martina M Erichsen
Martina M Erichsen
Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
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Eystein S Husebye
Eystein S Husebye
Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
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Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
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Kristian Løvås
Kristian Løvås
Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
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Department of Clinical Science, Department of Medicine, University of Bergen, N-5021 Bergen, Norway
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, 11-deoxycortisol (11DOC), testosterone, androstenedione, 17α-hydroxyprogesterone (17OHP) and progesterone were obtained from Steraloids, Inc. (Newport, RI, USA), and DXM was obtained from Alfa Aesar (Ward Hill, MA, USA). The deuterated internal
Anette Lundqvist
Anette Lundqvist
Department of Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, Sweden
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Herbert Sandström
Herbert Sandström
Department of Public Health and Clinical Medicine, Family Medicine, Umeå University, Umeå, Sweden
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Torbjörn Bäckström
Torbjörn Bäckström
Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University, Umeå, Sweden
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energy requirements in well-nourished pregnant women are about an extra 321 MJ (1 megajoule = 239 kilocalorie = 1000 kilojoules), distributed over pregnancy to provide adequate nutrition and energy supply for both mother and fetus ( 7 ). Progesterone
Henrik Ryberg
Henrik Ryberg
Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Anna-Karin Norlén
Anna-Karin Norlén
Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Andreas Landin
Andreas Landin
Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden
Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Per Johansson
Per Johansson
Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Zeinab Salman
Zeinab Salman
Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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Anders Wallin
Anders Wallin
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden
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Johan Svensson
Johan Svensson
Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
Department of Endocrinology, Skaraborg Central Hospital, Skövde, Sweden
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Department of Endocrinology, Skaraborg Central Hospital, Skövde, Sweden
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Claes Ohlsson
Claes Ohlsson
Sahlgrenska Osteoporosis Centre, Center for Bone and Arthritis Research (CBAR), Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
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PubMed
Search for other papers by Claes Ohlsson in
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PubMed
progesterone (P) ( 1 ). Circulating sex steroid levels may contribute to the levels seen in cerebrospinal fluid (CSF), but the relative contributions of local production vs peripheral sources to sex steroid levels in the CNS are not well understood ( 2
