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linear regression analyses in all recruited patients with T2D. After adjusting for demographic parameters, lipids profile, Scr, HbA1c, coagulation function indices and glucose-lowering therapies by multivariate linear regression analyses, HOMA-IR ( β
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count (Automatic Blood Cell Analyzer, Sysmex XN9000), biochemical parameters test (Automatic Biochemical Analyzer, Roche Cobas 8000), and fibrinogen (FIB, CS5100, Sysmex Corporation) respectively. Neutrophil to lymphocyte ratio (NLR) is the ratio of
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completely complied with the Declaration of Helsinki. Upon enrollment, each subject provided a written informed consent. Basic data collection Clinical data including age, sex, smoking, medical history, and anthropometry parameters were obtained from
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Department of Endocrinology, Suichang County Hospital of Traditional Chinese Medicine, Lishui, China
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uptake scans were performed before the patients received treatment. White blood cell (WBC) count, neutrophil (Neu) count, mean platelet volume (MPV), platelets (PLT), and lymphocytes were measured using an automatic blood analysis line (CAL-8000; Mindray
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Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
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(LOT # 1316723, R&D Systems) according to the manufacturer’s instructions and our previously reported methods ( 38 ). A dose-response curve using a best fit of a 4-parameter logistic equation was used to calculate the total chemerin concentration
Department of Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden
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Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
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Center for Neurology, Academic Specialist Center, Stockholm, Sweden
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Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden
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sodium; non-hypernatremia (<145 mmol/L), moderate hypernatremia (145–149 mmol/L), and severe hypernatremia (>149 mmol/L). Presence of hyponatremia, defined as plasma sodium < 137 mmol/L, was also recorded. Laboratory parameters were collected from the
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Division of Vascular Medicine, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands
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Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK
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(depending on the normality of the distribution) for continuous parameters and with the Fisher Exact test in case of categorical data. Differences between subgroups were tested using ANOVA. Group matching of patients and controls was performed by testing for
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reported to be prognostic predictive factors in various types of cancer. In particular, among these, the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) have been reported to be prognostic
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evaluating hepatic fibrosis ( 25 ). It is superior to other noninvasive markers of hepatic fibrosis in Japanese patients with NAFLD, with a high negative predictive value for excluding advanced fibrosis ( 26 ). FIB4 = (age (years) × AST (U/L))/(platelet
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Guangdong Geriatric Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Reproductive Medicine Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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. Healthy subjects without any past or present history of thyroid disease were enrolled in this study. Clinical parameters, including thyrotropin (TSH), FT 3 , FT 4 , thyroperoxidase antibody (TPOAb), thyroglobulin antibody (TGAb) and TRAb levels, were