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Rajae Talbi and Victor M Navarro

potentially regulate metabolism (discussed in later sections), and (2) Kiss1 AVPV/PeN neurons to regulate fertility ( 10 , 11 ). An additional population of Kiss1 neurons has been recently identified in the posterodorsal part of the medial amygdala (Kiss1

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Athanasios D Anastasilakis, Marina Tsoli, Gregory Kaltsas and Polyzois Makras

lesional and systemic alterations of factors involved in bone metabolism, and the potential therapeutic implications for both bone and multisystem LCH management. LCH pathogenesis LCH is characterized by clonal proliferation and dissemination of

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Mohammed S Albreiki, Benita Middleton and Shelagh M Hampton

and glucose metabolism, such as glucose-6-phosphate dehydrogenase ( 7 , 8 ). Therefore, disruption of circadian coordination may be manifested by endocrine imbalances ( 9 ), incidence of obesity ( 10 ) and type 2 diabetes ( 11 , 12 ). This raises a

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Clarissa Souza Barthem, Camila Lüdke Rossetti, Denise P Carvalho and Wagner Seixas da-Silva

evaluate the effects of metformin administration in the metabolism of short-term ovariectomized rats, comparing to estrogen replacement. Metformin was able to partially prevent body mass gain and food efficiency, and the drug also prevented the increase in

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Alexis Sudlow, Carel W le Roux and Dimitri J Pournaras

by a powerful incretin effect resulting in increased GLP-1, PYY and alterations in bile acid metabolism ( 32 , 33 ). The fact that it is an infrequently performed procedure reflects that it is not only technically challenging but also associated with

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Kaisa K Ivaska, Maikki K Heliövaara, Pertti Ebeling, Marco Bucci, Ville Huovinen, H Kalervo Väänänen, Pirjo Nuutila and Heikki A Koistinen

Introduction Bone is increasingly recognized as an effector in energy metabolism via its interactions with other tissues (1, 2) . The role of bone-derived osteocalcin (OC) as a novel endocrine regulator of glucose and lipid metabolism was

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Thiago U Pantaleão, Andrea C F Ferreira, Maria C S Santos, Álvaro S P Figueiredo, Ruy A N Louzada, Doris Rosenthal, Denise P Carvalho and Vânia M Corrêa da Costa

important deleterious effects on central nervous system. In the brain, most nuclear triiodothyronine (T 3 ) is locally produced from the prohormone thyroxine (T 4 ) by type 2 iodothyronine deiodinase (D2) ( 5 ). Since deiodinases regulate the metabolism of

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Nicolai Preisler, Pascal Laforêt, Karen Lindhardt Madsen, Edith Husu, Christoffer Rasmus Vissing, Gitte Hedermann, Henrik Galbo, Christopher Lindberg and John Vissing

during prolonged (i.e. 1 h) moderate intensity exercise, in patients with Pompe disease. We used cycle-ergometer exercise and stable isotope methodology in combination with indirect calorimetry to determine glucose, glycerol, and fatty acid metabolism

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Alessandro Ciresi, Stefano Radellini, Valentina Guarnotta, Maria Grazia Mineo and Carla Giordano

to standard GH doses ( 12 , 13 ). The sexual dimorphism of GH secretion also results in a different expression of some genes involved in glucose and lipid metabolism. There is strong evidence that estrogens can influence the GH-regulated endocrine

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Antonia Ertelt, Ann-Kristin Barton, Robert R Schmitz and Heidrun Gehlen

full and unique pattern of gene expression, regardless of their environment (33, 34, 35, 36) . Further research is required, particularly in equines, to evaluate the importance of the site of fat deposition and differences in metabolism of these fat