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Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland
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Achenbach SJ Lebrasseur N Bancos I . Frailty in patients with mild autonomous cortisol secretion is higher than in patients with nonfunctioning adrenal tumors . Journal of Clinical Endocrinology and Metabolism 2020 105 e3307 – e3315 . ( https
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Radiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, UK
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). Furthermore, they found that GH deficiency was associated with short stature, low bone mineral density, poor tolerance to exercise, as well as frailty. TSH deficiency was also associated with short stature and poor tolerance to exercise, in addition to LH
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growth and delayed puberty. Long-term, primary hypothyroidism has been associated with frailty, dyslipidemia and impaired physical quality of life in CCS ( 30 ). Given the trophic effect of TSH on epithelial thyroid cells, supraphysiologic doses of
Department of Diabetes and Endocrinology, Blacktown Hospital, Blacktown, New South Wales, Australia
Department of Diabetes and Endocrinology, Westmead Hospital, Westmead, New South Wales, Australia
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Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, Blacktown, New South Wales, Australia
School of Medicine, UNSW Sydney, Sydney, New South Wales, Australia
Translational Health Research Institute, Penrith, New South Wales, Australia
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Department of Diabetes and Endocrinology, Blacktown Hospital, Blacktown, New South Wales, Australia
Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
School of Medicine, UNSW Sydney, Sydney, New South Wales, Australia
Translational Health Research Institute, Penrith, New South Wales, Australia
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condition ( 27 ). Thus, ADT offers a unique accelerated model for studying male aging and frailty. ADT is associated with rapid changes in body composition, with a 2–4% reduction in LBM and 10–20% increase in FM after just 12 months of androgen deprivation
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hypothesize that a maximal stimulatory effect of IL-2 may be reached at a lower dose in older subjects, which could worsen frailty in aging individuals. More detailed research employing dose-response analysis is needed in this area. The observed age
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Deutsches Herzzentrum München, Technische Universität München, DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany
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Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
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German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Germany
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( 49 , 50 ). Unfortunately, BMI (which used in our analysis) is a relatively crude measure of body composition. Additionally, higher levels of SHBG are associated with increased frailty and fracture ( 11 , 51 ). Direct effect of SHBG – as
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University for Health Sciences, Medical Informatics and Technology (UMIT TIROL), Tirol, Austria
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Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), Faculty of Medicine, University of Bonn, Bonn, Germany
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Department of Neurology, Faculty of Medicine, University of Bonn, Bonn, Germany
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MB Fairhall N Walsh S Franks TC Kwok W Bauman A & Sherrington C . Evidence on physical activity and the prevention of frailty and sarcopenia among older people: a systematic review to inform the World Health Organization physical
Postgraduate Program in Nutritional Sciences, Department of Nutrition, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
University Centre of João Pessoa (UNIPE), João Pessoa, Paraíba, Brazil
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Postgraduate Program in Cognitive Neuroscience and Behavior, Center for Health Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil
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Department of Biorregulation, Health Sciences Institute, Federal University of Bahia, Bahia, Brazil
Postgraduate Program in Medicine and Health, Medical School of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil
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-19 outcomes ( 8 ). As an example, low lean mass and sarcopenia, although markers of frailty and aging, have also been independently associated with COVID-19 severity ( 9 ); importantly, obesity and sarcopenia can coexist in the same individual
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related complications and adverse events, such as falls, frailty, decreased exercise capacity, and impaired functionality and independence. Therefore, early recognition and intervention are necessary to retard the progress of muscle weakness and prevent
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mass index with frailty and all-cause mortality among middle-aged and older adults . BMC Medicine 2022 20 404 . ( https://doi.org/10.1186/s12916-022-02596-7 ) 20 Reference Values for Arterial Stiffness ’ Collaboration . Determinants of pulse wave