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endogenous or exogenous estrogen exposure without progesterone protection is the leading cause of type1 EC ( 2 , 3 ). Accumulating epidemiological evidence also demonstrated that insulin resistance was highly prevalent in endometrial cancer ( 4 , 5 , 6
Department of Endocrinology, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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prior to the onset of symptoms and persisting for several decades ( 3 ). With the exception of autoimmune polyglandular syndrome 1, which is associated with consistent rapid progression to adrenal insufficiency in childhood, our understanding of the
Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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Key Laboratory of Sports Technique, Tactics and Physical Function of General Administration of Sport of China, Scientific Research Center, Guangzhou Sport University, Guangzhou, China
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our understanding of adipose tissue homeostasis . Nature Reviews: Endocrinology 2015 11 71 – 72 . ( https://doi.org/10.1038/nrendo.2014.219 ) 28 Karpe F Tan GD Adipose tissue function in the insulin-resistance syndrome . Biochemical
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). Recent studies have reported elevated plasma PANDER levels in individuals with T2DM ( 11 , 12 , 13 ), metabolic syndrome (MS) ( 14 ), and gestational diabetes mellitus (GDM) ( 15 ). Previous experiments have demonstrated that exogenous PANDER treatment
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with anti-PD-1 antibodies and hypophysitis (IH) commonly related to anti-CTLA-4 therapy, are the most frequent endocrine toxicities. ICI-induced insulin-deficient diabetes mellitus (DM) and primary adrenal insufficiency (PAI), though rare, can be life
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obtained at 1 h after the GTT ( 26 ). This result has been partially attributed to the fact that high exogenous glucose can stimulate somatostatin secretion in pancreatic D cells, which in turn can inhibit insulin secretion during the initial period after
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Pirulli A Mucci M Dore F Fonda M Ciocchi B Cattin L Relationships between desacylated and acylated ghrelin and insulin sensitivity in the metabolic syndrome . Journal of Clinical Endocrinology & Metabolism
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metabolic parameters measured in this study. Previous studies reported that ghrelin levels in obese, insulin-resistant, or metabolic syndrome patients were reduced ( 35 , 36 , 37 ), and such reduction of ghrelin contributed to the development of T2D ( 38
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Laboratory Medicine, University of Groningen, University Medical Center, Groningen, the Netherlands
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Department of Internal Medicine, VUMC Free University, Amsterdam, the Netherlands
Wallenberg Laboratory, Sahlgrenska Hospital, University of Gothenburg, Gothenburg, Sweden
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Horaizon BV, Delft, the Netherlands
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RS. Improvement of insulin sensitivity after lean donor fecal microbiota transplantation in metabolic syndrome subjects is associated with baseline intestinal microbiota composition . Cell Metabolism 2017 26 611.e6 – 619.e6 . ( https
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be one of the factors involved in their higher risk of metabolic syndrome and type 2 DM ( 26 ) and their higher cardiovascular mortality ( 27 , 28 ). Polycystic ovary syndrome (PCOS) Anovulation, oligo-amenorrhea, hirsutism, acne, insulin