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Yusaku Mori, Eunhyoung Ko, Rudolf Furrer, Linda C Qu, Stuart C Wiber, I George Fantus, Mario Thevis, Alan Medline and Adria Giacca

commonest condition of insulin resistance, that is, after high-fat diet. We used a model of oestrogen-dependent carcinoma (commonest form of breast cancer), the N-methyl-N-nitrosourea (MNU)-induced mammary tumour model ( 27 ). Materials and methods

Open access

Yuan Fang, Xuehong Zhang, Huilin Xu, Stephanie A Smith-Warner, Dongli Xu, Hong Fang and Wang Hong Xu

the strongest associations being observed for liver, pancreatic and endometrial cancers and more moderate associations observed for breast, colorectal and bladder cancer. An inverse association has been consistently observed for prostate cancer, while

Open access

M Jensterle, A Podbregar, K Goricar, N Gregoric and A Janez

other pituitary hormones and pituitary MRI to exclude hypopituitarism and/or pituitary or hypothalamic tumor or infiltrative disease was performed when it was clinically indicated ( 15 ). Other exclusion criteria were iron overload, history of carcinoma

Open access

Michael Ulm, Arvind V Ramesh, Keely M McNamara, Suriyan Ponnusamy, Hironobu Sasano and Ramesh Narayanan

ERs tissue selectively. Tamoxifen functions as an antagonist in breast tissue, rendering anti-proliferative effects. However, tamoxifen is an agonist in the uterus and endometrium thereby increasing the chances of endometrial cancer. Similarly

Open access

Daiki Kobayashi, Nagato Kuriyama, Keita Hirano, Osamu Takahashi and Hiroshi Noto

.40), hepatocellular carcinoma (HR: 1.97), pancreatic cancer (HR: 1.85) and cholangiocarcinoma (HR: 1.66) ( 3 , 5 , 6 , 7 , 8 ). Other malignancies, such as esophageal cancer, gastric cancer or lung cancer, may have no association with diabetes ( 9 , 10 , 11

Open access

Doron Weinstein, Rive Sarfstein, Zvi Laron and Haim Werner

carcinoma (13) . C4-2 is an androgen-independent, androgen-insensitive subline of LNCaP cells. PC3, LNCaP, and C4-2 cells were maintained in RPMI 1640 medium supplemented with 10% FBS, glutamine, and gentamicin sulfate. The cells were treated with IGF1

Open access

Renea A Taylor, Jennifer Lo, Natasha Ascui and Matthew J Watt

approximately one-third of cancer-related deaths in 2012 (8) . Obesity contributes to both the increased incidence and/or progression of many cancers including endometrial, bowel, (postmenopausal) breast and prostate cancer (9) . While there is an association

Open access

Agnieszka Kosowska, Enrique Gallego-Colon, Wojciech Garczorz, Agnieszka Kłych-Ratuszny, Mohammad Reza F Aghdam, Michał Woz´niak, Andrzej Witek, Agnieszka Wróblewska-Czech, Anna Cygal, Jerzy Wojnar and Tomasz Francuz

inhibits tamoxifen–DNA adducts in endometrial explant culture . Biochemical and Biophysical Research Communications 2003 307 157 – 164 . ( doi:10.1016/S0006-291X(03)01134-3 ) 10.1016/S0006-291X(03)01134-3 12849995 23 Furukawa S Soeda S

Open access

Yao Chen and Shu-ying Fang

Pillay OC Atiomo W. Polycystic ovary syndrome and endometrial carcinoma . Lancet 2003 361 1810 – 1812 . ( https://doi.org/S0140673603134095 ) 12781553 10.1016/S0140-6736(03)13409-5 5 Segars JH DeCherney AH. Is there a genetic basis for

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André Marques-Pinto and Davide Carvalho

recent study has shown that women with endometriosis have significantly higher concentrations of TCDD and PCB in the peritoneal fluid (163) , possibly leading to chronic inflammation, which may result in the stimulation of endometrial cells derived from