Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Search for other papers by Jesper Krogh in
Google Scholar
PubMed
Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
Search for other papers by Peter Plomgaard in
Google Scholar
PubMed
Department of Clinical Biochemistry, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
Search for other papers by Ruth Frikke-Schmidt in
Google Scholar
PubMed
Search for other papers by Sten Velschow in
Google Scholar
PubMed
Department of Pediatrics, Copenhagen University Hospital - Herlev & Gentofte, Copenhagen, Denmark
Search for other papers by Jesper Johannesen in
Google Scholar
PubMed
Search for other papers by Linda Maria Hilsted in
Google Scholar
PubMed
Search for other papers by Malene Schrøder in
Google Scholar
PubMed
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Search for other papers by Ulla Feldt-Rasmussen in
Google Scholar
PubMed
man-hours needed for serial sampling and minimizes the risks of sample loss, wrong timing, misidentification, and contamination. The volumetric DBS technology used in the Fluispotter has previously been tested ex vivo for cortisol assessment by
Search for other papers by Soraya Puglisi in
Google Scholar
PubMed
Search for other papers by Paola Perotti in
Google Scholar
PubMed
Search for other papers by Mattia Barbot in
Google Scholar
PubMed
Search for other papers by Paolo Cosio in
Google Scholar
PubMed
Search for other papers by Carla Scaroni in
Google Scholar
PubMed
Search for other papers by Antonio Stigliano in
Google Scholar
PubMed
Search for other papers by Pina Lardo in
Google Scholar
PubMed
Search for other papers by Valentina Morelli in
Google Scholar
PubMed
Search for other papers by Elisa Polledri in
Google Scholar
PubMed
Search for other papers by Iacopo Chiodini in
Google Scholar
PubMed
Search for other papers by Giuseppe Reimondo in
Google Scholar
PubMed
Search for other papers by Anna Pia in
Google Scholar
PubMed
Search for other papers by Massimo Terzolo in
Google Scholar
PubMed
mortality ratio between 2.0 and 4.0 ( 2 ). Because of these clinical consequences, CS requires a prompt and definitive resolution since the duration of exposure to cortisol excess is a factor portending a worse prognosis ( 3 ). Surgery is the mainstay of
Non-communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa
Search for other papers by Siphiwe N Dlamini in
Google Scholar
PubMed
Search for other papers by Zané Lombard in
Google Scholar
PubMed
Search for other papers by Lisa K Micklesfield in
Google Scholar
PubMed
Search for other papers by Nigel Crowther in
Google Scholar
PubMed
Search for other papers by Shane A Norris in
Google Scholar
PubMed
Search for other papers by Tracy Snyman in
Google Scholar
PubMed
BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
Search for other papers by Andrew A Crawford in
Google Scholar
PubMed
Institute of Genetic Medicine to Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK
Search for other papers by Brian R Walker in
Google Scholar
PubMed
Non-communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa
Search for other papers by Julia H Goedecke in
Google Scholar
PubMed
cortisol leads to Cushing’s syndrome, which exhibits metabolic features similar to metabolic syndrome ( 2 ). Accordingly, previous cross-sectional studies suggest that circulating cortisol concentrations are associated with metabolic syndrome, its
Search for other papers by Sarah Zaheer in
Google Scholar
PubMed
Search for other papers by Kayla Meyer in
Google Scholar
PubMed
Search for other papers by Rebecca Easly in
Google Scholar
PubMed
Search for other papers by Omar Bayomy in
Google Scholar
PubMed
Search for other papers by Janet Leung in
Google Scholar
PubMed
Search for other papers by Andrew W Koefoed in
Google Scholar
PubMed
Search for other papers by Mahyar Heydarpour in
Google Scholar
PubMed
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Search for other papers by Roy Freeman in
Google Scholar
PubMed
Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA
Harvard Medical School, Boston, Massachusetts, USA
Search for other papers by Gail K Adler in
Google Scholar
PubMed
following a bout of intense physical exercise in healthy humans ( 29 , 30 , 31 ). This increase in sclerostin is accompanied by activation of the pituitary–adrenal axis, raising the possibility that acute increases in cortisol due to pituitary
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
Search for other papers by Milène Tetsi Nomigni in
Google Scholar
PubMed
Search for other papers by Sophie Ouzounian in
Google Scholar
PubMed
Search for other papers by Alice Benoit in
Google Scholar
PubMed
Search for other papers by Jacqueline Vadrot in
Google Scholar
PubMed
Search for other papers by Frédérique Tissier in
Google Scholar
PubMed
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
Search for other papers by Sylvie Renouf in
Google Scholar
PubMed
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
Search for other papers by Hervé Lefebvre in
Google Scholar
PubMed
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
Search for other papers by Sophie Christin-Maitre in
Google Scholar
PubMed
INSERM, University of Rouen, Department of Endocrinology, Departments of Endocrinology, Pathology, Department of Pathology, Department of Endocrinology, INSERM, U982, Laboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institute for Research and Innovation in Biomedicine, Mont‐Saint‐Aignan, France
Search for other papers by Estelle Louiset in
Google Scholar
PubMed
androgen and cortisol oversecretion is highly suggestive of adrenocortical carcinoma (12) . In very few cases, androgen-secreting adrenal lesions have been identified as bilateral macronodular hyperplasia (13, 14) , adenoma (15) , primary pigmented
Search for other papers by Boni Xiang in
Google Scholar
PubMed
Search for other papers by Ran Tao in
Google Scholar
PubMed
Search for other papers by Xinhua Liu in
Google Scholar
PubMed
Search for other papers by Xiaoming Zhu in
Google Scholar
PubMed
Search for other papers by Min He in
Google Scholar
PubMed
Search for other papers by Zengyi Ma in
Google Scholar
PubMed
Search for other papers by Yehong Yang in
Google Scholar
PubMed
Search for other papers by Zhaoyun Zhang in
Google Scholar
PubMed
Search for other papers by Yiming Li in
Google Scholar
PubMed
Search for other papers by Zhenwei Yao in
Google Scholar
PubMed
Search for other papers by Yongfei Wang in
Google Scholar
PubMed
Search for other papers by Hongying Ye in
Google Scholar
PubMed
impairment was relieved after a pituitary implant of 198 Au ( 6 ). Primary cortisol deficiency was reported concomitant with high TSH and low FT3. After cortisone administration, TSH returned to normal. However, serum cortisol and TSH showed no significant
Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon, USA
Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA
Department of Physiology & Pharmacology, Oregon Health & Science University, Portland, Oregon, USA
Search for other papers by Henryk F Urbanski in
Google Scholar
PubMed
Search for other papers by Kevin Mueller in
Google Scholar
PubMed
Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Beaverton, Oregon, USA
Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, Oregon, USA
Search for other papers by Cynthia L Bethea in
Google Scholar
PubMed
. Blood samples were collected from each animal under ketamine HCl sedation (10 mg/kg body weight, intramuscular), at Month −1 and again at Month 24; the serum was stored frozen at −20°C and subsequently assayed for leptin, cortisol and DHEAS. Note
Search for other papers by Jonneke J Hollanders in
Google Scholar
PubMed
Search for other papers by Bibian van der Voorn in
Google Scholar
PubMed
Search for other papers by Noera Kieviet in
Google Scholar
PubMed
Search for other papers by Koert M Dolman in
Google Scholar
PubMed
Search for other papers by Yolanda B de Rijke in
Google Scholar
PubMed
Search for other papers by Erica L T van den Akker in
Google Scholar
PubMed
Search for other papers by Joost Rotteveel in
Google Scholar
PubMed
Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
Search for other papers by Adriaan Honig in
Google Scholar
PubMed
Search for other papers by Martijn J J Finken in
Google Scholar
PubMed
estriol) and precursor GCs, since the adrenocortical enzymes are not fully matured yet ( 5 ). Subsequently, during the last 6–8 weeks of pregnancy, the more matured fetal adrenal produces increasing amounts of cortisol and cortisone under the control of
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
Search for other papers by Anne-Sophie C A M Koning in
Google Scholar
PubMed
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
Search for other papers by Philippe C Habets in
Google Scholar
PubMed
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
Search for other papers by Marit Bogaards in
Google Scholar
PubMed
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
Search for other papers by Jan Kroon in
Google Scholar
PubMed
Department of Pediatric Neuro-Oncology, Prinses Máxima Centrum, Utrecht, The Netherlands
Search for other papers by Hanneke M van Santen in
Google Scholar
PubMed
Search for other papers by Judith M de Bont in
Google Scholar
PubMed
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
Search for other papers by Onno C Meijer in
Google Scholar
PubMed
naturally produced glucocorticoid hormone cortisol. Cortisol also acts via the mineralocorticoid receptor (MR) in many tissues including the brain ( 6 ), but synthetic glucocorticoids have a clear preference for GR over MR ( 7 ). Both receptor types are
Search for other papers by Dorte Glintborg in
Google Scholar
PubMed
Search for other papers by Magda Lambaa Altinok in
Google Scholar
PubMed
Search for other papers by Pernille Ravn in
Google Scholar
PubMed
Search for other papers by Kurt Bjerregaard Stage in
Google Scholar
PubMed
Search for other papers by Kurt Højlund in
Google Scholar
PubMed
Search for other papers by Marianne Andersen in
Google Scholar
PubMed
increased ovarian and adrenal androgen production ( 1 ). Adrenocorticotropic hormone (ACTH)-stimulated cortisol and 17-hydroxyprogesterone levels (17OHP) and urinary cortisol secretion were increased in women with PCOS vs controls ( 7 , 8 ), suggesting