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June Young Choi, Jin Wook Yi, Jun Hyup Lee, Ra-Yeong Song, Hyeongwon Yu, Hyungju Kwon, Young Jun Chai, Su-jin Kim and Kyu Eun Lee

between vitamin D and cancer prevention has been shown in breast, prostate and colorectal cancer ( 22 ). It rises to a consensus conference by the World Health Organization evaluating the evidence associated with vitamin D and cancer ( 23 ). Observational

Open access

Djeda Belharazem, Matthias Kirchner, Franziska Geissler, Peter Bugert, Martin Spahn, Burkhard Kneitz, Hubertus Riedmiller, Christian Sauer, Stefan Küffer, Lutz Trojan, Christian Bolenz, Maurice Stephan Michel, Alexander Marx and Philipp Ströbel

detection and prevention. LOI of IGF2 has previously been described in normal circulating peripheral blood lymphocytes of individuals with an increased risk to develop colorectal cancer (11, 12, 13) . IGF2 and H19 belong to the same locus and share

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Daiki Kobayashi, Nagato Kuriyama, Keita Hirano, Osamu Takahashi and Hiroshi Noto

cancer 68 18.1 Lung cancer 40 10.6 Colorectal cancer 38 10.1 Esophagus cancer 30 8 Breast cancer 21 5.6 Bladder and ureteral cancer 18 4.8 Liver cancer 14 3.7 Others 14 3

Open access

T P McVeigh, R J Mulligan, U M McVeigh, P W Owens, N Miller, M Bell, F Sebag, C Guerin, D S Quill, J B Weidhaas, M J Kerin and A J Lowery

variant with disease. Our criteria for inclusion of participants as controls was much more stringent than in this study, where controls were recruited from the national blood donor service, the 1958 Birth cohort, and from a separate colorectal cancer

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Juan Carlos Juárez-Cruz, Miriam Daniela Zuñiga-Eulogio, Monserrat Olea-Flores, Eduardo Castañeda-Saucedo, Miguel Ángel Mendoza-Catalán, Carlos Ortuño-Pineda, Ma Elena Moreno-Godínez, Sócrates Villegas-Comonfort, Teresita Padilla-Benavides and Napoleón Navarro-Tito

, secretion and activation which in turn correlates with a highly invasive capacity of tumor cells ( 23 ). In particular, MMP-2 and MMP-9 degrade type IV collagen and promote the rupture of basal membranes in colorectal, prostate, lung and breast cancers ( 24

Open access

Linfei Yang, Xiao Yu and Yongchao Yang

, renal cell carcinoma, gastric cancer and colorectal cancer, by enhancing the expression of angiogenesis-related genes such as VEGF ( 20 , 21 , 22 , 23 ). ATX has been reported to be a target of STAT3 transcriptional regulation in breast cancer ( 24

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Elham Barazeghi, Per Hellman, Gunnar Westin and Peter Stålberg

hypermethylation and loss of heterozygosity, with a putative tumor-suppressive role of PTPRM, was demonstrated in colorectal cancer ( 11 , 12 ). PTPRM has been shown to have a crucial role in epidermal growth factor receptor signaling, and downregulation of PTPRM

Open access

Tiemo S Gerber, Arno Schad, Nils Hartmann, Erik Springer, Ulrich Zechner and Thomas J Musholt

locus, suggesting that there is no mutational hotspot present. This locus is known to be altered in WDTC, oesophageal adenocarcinoma, pancreatic cancer and colorectal cancer ( 27 , 28 , 29 ). A SMAD4 immunohistochemistry expression study has shown a

Open access

Aida Javanbakht, Massimo D’Apuzzo, Behnam Badie and Behrouz Salehian

. 15678907 131 Lerdlum S Shuangshoti S Lerdlum S Siwanuwatn R Sunthornyothin S . Colorectal cancer manifesting with metastasis to prolactinoma: report of a case involving symptoms mimicking pituitary apoplexy. Internal Medicine 2014 53 1965 – 1969

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Kirsty G Pringle, Sarah J Delforce, Yu Wang, Katie A Ashton, Anthony Proietto, Geoffrey Otton, C Caroline Blackwell, Rodney J Scott and Eugenie R Lumbers

J. Hereditary nonpolyposis colorectal cancer in 95 families: differences and similarities between mutation-positive and mutation-negative kindreds . American Journal of Human Genetics 2001 68 118 – 127 . ( doi:10.1086/316942 ) 16 Gaunt TR