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Cheryl M Isherwood Section of Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

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M Denise Robertson Section of Metabolic Medicine, Food and Macronutrients, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

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Debra J Skene Section of Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

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Jonathan D Johnston Section of Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom

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Introduction Many aspects of endocrinology and metabolism exhibit 24-h rhythms that are driven by an endogenous circadian timing system ( 1 , 2 , 3 ). This circadian system is comprised of a central light-entrained clock in the

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-23-0064
Volume/Issue:
Volume 12: Issue 11
Open access
Jessica S Jarmasz Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

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Yan Jin Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

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Hana Vakili Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

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Peter A Cattini Department of Physiology & Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada

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has been heavily studied ( 2 ). Serum levels of hGH vary considerably over the course of the day and during the night as it is dependent on a variety of factors including (and not limited to) the circadian rhythm, sleep–wake cycle, diet, metabolism

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0354
Volume/Issue:
Volume 9: Issue 12
Open access
Mohammed S Albreiki Department of Biochemistry and Physiology, Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK

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Benita Middleton Department of Biochemistry and Physiology, Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK

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Shelagh M Hampton Department of Biochemistry and Physiology, Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK

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Introduction Artificial light exposure at night has become commonplace throughout the developed world ( 1 , 2 ). Light has been linked to various complex mechanisms such as the synchronisation of the circadian system ( 3 ). Circadian rhythms

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-16-0097
Volume/Issue:
Volume 6: Issue 2
Open access
Robert Maidstone Oxford Centre for Diabetes, Endocrinology and Metabolism, and Oxford Kavli Centre for Nanoscience Discovery, University of Oxford, Oxford, UK
Centre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

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Martin K Rutter Centre for Biological Timing, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
Diabetes, Endocrinology and Metabolism Centre, Manchester University NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester, UK

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Thomas Marjot Oxford Centre for Diabetes, Endocrinology and Metabolism, and Oxford Kavli Centre for Nanoscience Discovery, University of Oxford, Oxford, UK
Oxford Liver Unit, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, UK

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David W Ray Oxford Centre for Diabetes, Endocrinology and Metabolism, and Oxford Kavli Centre for Nanoscience Discovery, University of Oxford, Oxford, UK
NIHR Oxford Health Biomedical Research Centre, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK

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Matthew Baxter Oxford Centre for Diabetes, Endocrinology and Metabolism, and Oxford Kavli Centre for Nanoscience Discovery, University of Oxford, Oxford, UK
NIHR Oxford Health Biomedical Research Centre, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK

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nucleus (SCN). The SCN receives light information from the retina. The timekeeping mechanism is composed of a transcriptional–translational feedback loop, which has an intrinsic period of approximately 24 h. Circadian rhythms are critically important for

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-23-0472
Volume/Issue:
Volume 13: Issue 2
Open access
Carlo Cinque Fondazione Ethoikos, Radicondoli, Italy
Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Rome, Italy

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Manuela Zinni Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Rome, Italy

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Anna Rita Zuena Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Rome, Italy

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Chiara Giuli Fondazione Ethoikos, Radicondoli, Italy

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Sebastiano G Alemà Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Rome, Italy

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Assia Catalani Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Rome, Italy

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Paola Casolini Department of Physiology and Pharmacology V. Erspamer, Sapienza University of Rome, Rome, Italy

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Roberto Cozzolino Fondazione Ethoikos, Radicondoli, Italy

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that the exposure to EE ( 25 ) or to the odour of a phobic stimulus such as predator scent ( 26 ) induces an increase of plasma corticosterone concentrations in rats. We also assessed FCM circadian rhythm in socially isolated male and female rats in

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0338
Volume/Issue:
Volume 7: Issue 2
Open access
Patricia Arroyo Tardio University Hospital Basel, Basel, Switzerland

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Gabriela Baldini University Clinic of Medicine, Cantonal Hospital Baselland, Liestal, Switzerland

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Eleonora Seelig University Hospital Basel, Basel, Switzerland
University Clinic of Medicine, Cantonal Hospital Baselland, Liestal, Switzerland

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Introduction The hypothalamopituitary–adrenal (HPA) axis tightly regulates cortisol secretion ( 1 ). Cortisol is secreted in a circadian rhythm with a brisk increase upon awakening and a nadir around midnight ( 1 ). Food is an external factor

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-23-0126
Volume/Issue:
Volume 12: Issue 7
Open access
Carlijn A Hoekx Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Borja Martinez-Tellez Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
Department of Nursing Physiotherapy and Medicine, SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almería, Almería, Spain
Biomedical Research Unit, Torrecárdenas University Hospital, Almería, Spain
CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain

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Maaike E Straat Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Magdalena M A Verkleij Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Mirjam Kemmeren Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Sander Kooijman Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Martin Uhrbom Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca Gothenburg, Sweden
Department of Medicine, Huddinge, Karolinska Institutet Campus Flemingsberg, Neo Building, Huddinge, Sweden

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Saskia C A de Jager Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands

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Patrick C N Rensen Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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Mariëtte R Boon Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands

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characteristics of this cohort has been extensively described elsewhere ( 12 ). To study the influence of circadian rhythm on cold-induced changes in serum GDF15 and FGF21 levels, a general linear model with repeated measures was used, with two within

Article Type:
Research Article
Collections:
Obesity
DOI:
https://doi.org/10.1530/EC-24-0074
Volume/Issue:
Volume 13: Issue 7
Open access
L Bahler Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands

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H J Verberne Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands

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E Brakema Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands

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R Tepaske Intensive Care Medicine, Academic Medical Center, Amsterdam, The Netherlands

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J Booij Nuclear Medicine, Academic Medical Center, Amsterdam, The Netherlands

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J B Hoekstra Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands

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F Holleman Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands

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patients with diabetes mellitus type 2, whereas in lean subjects, there is no pathological condition. Secondly, the timing of the bromocriptine may have interfered with the normal circadian dopamine rhythm ( 12 , 13 , 14 ). The aim of this clinical

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-16-0051
Volume/Issue:
Volume 5: Issue 6
Open access
Kim K B Clemmensen Department of Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark

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Jonas S Quist Department of Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark

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Dorte Vistisen Department of Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark

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Daniel R Witte Department of Public Health, Aarhus University, Aarhus, Denmark
Danish Diabetes Academy, Odense, Denmark

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Anna Jonsson NNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark

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Oluf Pedersen NNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark

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Torben Hansen NNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark

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Jens J Holst NNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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Torsten Lauritzen Section for General Practice, Department of Public Health, Aarhus University, Aarhus, Denmark

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Marit E Jørgensen Department of Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark
National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark

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Signe Torekov NNF Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

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Kristine Færch Department of Clinical Epidemiology, Steno Diabetes Center Copenhagen, Gentofte, Denmark

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A LECesi L Guidone C Nanni G Holst JJ . Circadian rhythms of GIP and GLP1 in glucose-tolerant and in type 2 diabetic patients after biliopancreatic diversion . Diabetologia 2009 52 873 – 881 . ( https://doi.org/10.1007/s00125

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0009
Volume/Issue:
Volume 9: Issue 4
Open access
Carla Scaroni Dipartimento di Medicina, U.O.C. Endocrinologia, Università di Padova, Padova, Italy

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Nora M Albiger Dipartimento di Medicina, U.O.C. Endocrinologia, Università di Padova, Padova, Italy

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Serena Palmieri Department of Clinical Sciences and Community Health, University of Milan, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico, Milan, Italy

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Davide Iacuaniello Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Napoli, Italy

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Chiara Graziadio Department of Experimental Medicine, University La Sapienza, Rome, Italy

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Luca Damiani Department of Medical Sciences, Endocrinology and Internal Medicine Section, University of Ferrara, Ferrara, Italy

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Marialuisa Zilio Dipartimento di Medicina, U.O.C. Endocrinologia, Università di Padova, Padova, Italy

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Antonio Stigliano Department of Clinical and Molecular Medicine, Sant’Andrea Hospital, University La Sapienza, Rome, Italy

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Annamaria Colao Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Napoli, Italy

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Rosario Pivonello Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Napoli, Italy

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the Altogether to Beat Cushing’s Syndrome (ABC) study group
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suspected CS was confirmed by the lack of cortisol suppression after 1 mg dexamethasone (10 µg/dL, n.v. <1.8) and the absence of a cortisol circadian rhythm (midnight serum cortisol, MserC, 12 µg/dL; n.v. <7.5). Which clinical features are the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-19-0435
Volume/Issue:
Volume 9: Issue 1
Open access