Michael Ulm
Michael Ulm
University of Tennessee Health Science Center, Memphis, Tennessee, USA
West Cancer Center, Memphis, Tennessee, USA
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West Cancer Center, Memphis, Tennessee, USA
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Arvind V Ramesh
Arvind V Ramesh
White Station High School, Memphis, Tennessee, USA
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Keely M McNamara
Keely M McNamara
Tohoku University, Miyagi, Japan
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Suriyan Ponnusamy
Suriyan Ponnusamy
University of Tennessee Health Science Center, Memphis, Tennessee, USA
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Hironobu Sasano
Hironobu Sasano
Tohoku University, Miyagi, Japan
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Ramesh Narayanan
Ramesh Narayanan
University of Tennessee Health Science Center, Memphis, Tennessee, USA
West Cancer Center, Memphis, Tennessee, USA
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West Cancer Center, Memphis, Tennessee, USA
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Introduction As a class, hormone-dependent cancers, including cancers of the breast, prostate and ovaries, contribute to the majority of cancer incidences in the United States and around the world. Over 400,000 men and women were affected by
Shuang Ye
Shuang Ye
Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China
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Yuanyuan Xu
Yuanyuan Xu
Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China
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Jiehao Li
Jiehao Li
Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China
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Shuhui Zheng
Shuhui Zheng
Research Center for Translational Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
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Peng Sun
Peng Sun
Department of Pathology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China
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Tinghuai Wang
Tinghuai Wang
Department of Physiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China
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Background Triple-negative breast cancer (TNBC) is negative for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth receptor 2 (HER-2), and accounts for 15–20% of all breast cancers ( 1 ). Due to this lack of the
Margarida Brito
Margarida Brito
Department of Medical Oncology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal
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Susana Prazeres
Susana Prazeres
Department of Clinical Pathology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal
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Marta Malheiros
Marta Malheiros
Department of Clinical Pathology, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal
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Introduction Fulvestrant was the first selective estrogen receptor degrader (SERD) ( 1 ) to enter clinical practice and represents, alone or in combination with targeted therapies, a key compound for endocrine advanced breast cancer (ABC). As
Yuting Shao
Yuting Shao
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, China
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Xiaole Hu
Xiaole Hu
Department of Operating Room, Qilu Hospital of Shandong University, Shandong, China
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Yuxi Wang
Yuxi Wang
Department of Breast and Thyroid Surgery, People’s Hospital of Mengyin County, Linyi, Shandong, China
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Yi Shao
Yi Shao
Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China
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Luchuan Li
Luchuan Li
Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China
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Qingdong Zeng
Qingdong Zeng
Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China
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Hong Lai
Hong Lai
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, China
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Lei Sheng
Lei Sheng
Department of Thyroid Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China
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rheumatoid arthritis ( 7 ). Recently, several studies have demonstrated that 25(OH)D deficiency is associated with the risk and mortality of cancer, including breast, prostate, and colorectal cancer ( 8 , 9 , 10 , 11 , 12 , 13 ). In 2022, a historical
Tian Zhou
Tian Zhou
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
Department of Breast Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
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Department of Breast Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
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Dai-wei Zhao
Dai-wei Zhao
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
Department of Surgery, Second People's Hospital of Guizhou Province, Guiyang, Guizhou, China
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Department of Surgery, Second People's Hospital of Guizhou Province, Guiyang, Guizhou, China
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Ning Ma
Ning Ma
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
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Xue-ying Zhu
Xue-ying Zhu
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
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Xing-hong Chen
Xing-hong Chen
Department of Surgery, Second People's Hospital of Guizhou Province, Guiyang, Guizhou, China
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Xue Luo
Xue Luo
Department of Breast Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
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Song Chen
Song Chen
School of Clinical Medicine, GuiZhou Medical University, Guiyang, Guizhou, China
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Qing-jun Gao
Qing-jun Gao
Department of Thyroid Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China
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human chromosome 6p21.1 and encodes a protein composed of 680 amino acids ( 7 ). It has been shown that FOXP4 may be significantly upregulated in breast cancer ( 16 ), hepatocellular carcinoma ( 17 ), lung cancer ( 18 ), and laryngeal cancer ( 19 ), and
Katherine A Bolton
Katherine A Bolton
Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Kelly A Avery-Kiejda
Kelly A Avery-Kiejda
Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Elizabeth G Holliday
Elizabeth G Holliday
Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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John Attia
John Attia
Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
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Nikola A Bowden
Nikola A Bowden
Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
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Rodney J Scott
Rodney J Scott
Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia
Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, University Drive, Newcastle, New South Wales, Australia
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Priority Research Centre for Cancer, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia
Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia
Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, University Drive, Newcastle, New South Wales, Australia
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Introduction Endometrial cancer is the most common gynaecological malignancy in women from developed countries ( 1 ), and breast cancer is the most common cancer that develops in women worldwide and is responsible for the most female cancer
Virginie Grouthier
Virginie Grouthier
Department of Endocrinology and Reproductive Medicine, GH La Pitié-Salpêtrière Charles-Foix, Center for Rare Gynecological Diseases, Paris, France
Department of Endocrinology, Diabetes and Nutrition, University Hospital of Bordeaux, Bordeaux, France
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Department of Endocrinology, Diabetes and Nutrition, University Hospital of Bordeaux, Bordeaux, France
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Zeina Chakhtoura
Zeina Chakhtoura
Department of Endocrinology and Reproductive Medicine, GH La Pitié-Salpêtrière Charles-Foix, Center for Rare Gynecological Diseases, Paris, France
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Isabelle Tejedor
Isabelle Tejedor
Department of Endocrinology and Reproductive Medicine, GH La Pitié-Salpêtrière Charles-Foix, Center for Rare Gynecological Diseases, Paris, France
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Yasmina Badachi
Yasmina Badachi
Department of General Radiology, GH La Pitié-Salpêtrière Charles-Foix, Paris, France
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Vincent Goffin
Vincent Goffin
Inserm U1151 – CNRS UMR 8253, Institut Necker Enfants Malades (INEM), Faculté de Médecine Paris Descartes, Paris, France
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Philippe Touraine
Philippe Touraine
Department of Endocrinology and Reproductive Medicine, GH La Pitié-Salpêtrière Charles-Foix, Center for Rare Gynecological Diseases, Paris, France
Sorbonne Université, F-75013, Paris, France
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Sorbonne Université, F-75013, Paris, France
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Introduction Multiple fibroadenomas (MFA) of the breast, defined by the unilateral or bilateral existence of at least three fibroadenomas (FA) in one breast, is a rare benign disease, and thus its natural history is poorly understood ( 1
T P McVeigh
T P McVeigh
Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland
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R J Mulligan
R J Mulligan
Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland
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U M McVeigh
U M McVeigh
Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland
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P W Owens
P W Owens
Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland
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N Miller
N Miller
Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland
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M Bell
M Bell
Department of Endocrinology, School of Medicine, NUI Galway, Galway, Ireland
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F Sebag
F Sebag
Department of Endocrine Surgery Centre hospitalo-universitaire de La Conception, Assistance Publique Hôpitaux de Marseille, Marseille, France
Aix-Marseille Université, Faculté de Médecine, Marseille, France
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Aix-Marseille Université, Faculté de Médecine, Marseille, France
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C Guerin
C Guerin
Department of Endocrine Surgery Centre hospitalo-universitaire de La Conception, Assistance Publique Hôpitaux de Marseille, Marseille, France
Aix-Marseille Université, Faculté de Médecine, Marseille, France
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Aix-Marseille Université, Faculté de Médecine, Marseille, France
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D S Quill
D S Quill
Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland
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J B Weidhaas
J B Weidhaas
David Geffen School of Medicine, University of California, Los Angeles, USA
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M J Kerin
M J Kerin
Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland
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A J Lowery
A J Lowery
Discipline of Surgery, Lambe Institute for Translational Research, School of Medicine, NUI Galway, Galway, Ireland
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Background The association between breast and thyroid disorders has been widely explored with a large amount of epidemiological evidence linking breast and thyroid malignancies. However, the extent and explanation for this association have
Hyun-Ah Kim
Hyun-Ah Kim
Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea
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Jihye Choi
Jihye Choi
Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea
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Chan Sub Park
Chan Sub Park
Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea
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Min-Ki Seong
Min-Ki Seong
Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea
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Sung-Eun Hong
Sung-Eun Hong
Department of Translational Research, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea
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Jae-Sung Kim
Jae-Sung Kim
Division of Basic Radiation Bioscience, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea
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In-Chul Park
In-Chul Park
Division of Basic Radiation Bioscience, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea
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Jin Kyung Lee
Jin Kyung Lee
KIRAMS Radiation Biobank, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea
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Woo Chul Noh
Woo Chul Noh
Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea
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the ASTRRA trial investigators
the ASTRRA trial investigators
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Introduction Management of young patients with endocrine-sensitive breast cancer is challenging, due to various treatment regimens that may cause menopausal symptoms or infertility, and most importantly, affect the prognosis of the disease
Olav Inge Håskjold
Olav Inge Håskjold
Department of Breast and Endocrine Surgery, University Hospital of North Norway, Tromsø, Norway
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Henrik Stenestø Foshaug
Henrik Stenestø Foshaug
UiT – The Arctic University of Norway, Institute of Clinical Medicine
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Therese Benedikte Iversen
Therese Benedikte Iversen
Department of Radiology, University Hospital of North Norway, Harstad, Norway
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Helga Charlotte Kjøren
Helga Charlotte Kjøren
Department of Radiology, University Hospital of North Norway, Harstad, Norway
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Vegard Heimly Brun
Vegard Heimly Brun
Department of Breast and Endocrine Surgery, University Hospital of North Norway, Tromsø, Norway
UiT – The Arctic University of Norway, Institute of Clinical Medicine
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UiT – The Arctic University of Norway, Institute of Clinical Medicine
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Objective
The basis of thyroid nodule diagnostics is ultrasound-guided fine needle biopsy with cytological evaluation (FNC) if ultrasound appearance is not clearly benign. The aim of this study was to investigate the predictive potential of dedicated, expert high-resolution ultrasound, to see if histopathological entities of thyroid nodules can be diagnosed without invasive FNC biopsies.
Design
Prospective case-cohort study.
Methods
187 patients with 221 thyroid nodules were examined with ultrasound and prospectively assigned to the expected histopathological diagnosis: colloid nodule, adenomatoid colloid nodule, follicular adenoma, follicular carcinoma, follicular variant of papillary thyroid carcinoma, papillary thyroid carcinoma, or other thyroid cancer. In 101 of these, we later obtained histopathological reports for comparison.
Results
Overall accuracy for classification into discrete histopathological categories by expert ultrasound was 71.3% and Cohen’s Kappa was 0.62. The sensitivity and specificity for detecting malignancy were 97.3% and 78.1%. The diagnostic accuracy for malignancy was 85.1%. ACR-TIRADS scores for the same nodules had a sensitivity of 97.3%, specificity of 26.6%, and accuracy of 52.5%.
Conclusion
Dedicated expert high-resolution ultrasound without FNC can reliably distinguish benign vs malignant nodules, but also differentiate between several histopathological entities in thyroid nodules. There is potential for a reduction in the number of invasive FNC biopsies and diagnostic operations.
