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Lingjuan Li Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Jing Qin Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Lin Ren Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Shiyuan Xiang Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Xiaoyun Cao Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China

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Xianglan Zheng Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Zhiwen Yin Department of Nursing, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China

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Nidan Qiao Department of Neurosurgery, Huashan Hospital, Shanghai Medical School, Fudan University, Shanghai, China
National Center for Neurological Disorders, Shanghai, China
Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
Neurosurgical Institute of Fudan University, Shanghai, China
Shanghai Key Laboratory of Medical Brain Function and Restoration and Neural Regeneration, Fudan University, Shanghai, China

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approach). However, most patients have a risk of developing arginine vasopressin deficiency after surgery ( 1 , 2 ). Therefore, sufficient hydration is needed to maintain fluid balance. In some cases, however, negative fluid balances still occur. The most

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Kush Dev Singh Jarial Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Anil Bhansali Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Vivek Gupta Department of Radio-diagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Paramjeet Singh Department of Radio-diagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Kanchan K Mukherjee Department of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Akhilesh Sharma Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Rakesh K Vashishtha Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Suja P Sukumar Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Naresh Sachdeva Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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Rama Walia Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

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.1440499 13 Katoh K Yoshida M Kobayashi Y Onodera M Kogusa K Obara Y. Responses induced by arginine-vasopressin injection in the plasma concentrations of adrenocorticotropic hormone, cortisol, growth hormone and metabolites around weaning time in goats

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Milena Kloter Medical University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland
Faculty of Medicine, University of Basel, Basel, Switzerland

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Claudia Gregoriano Medical University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland

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Ellen Haag Medical University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland
Faculty of Medicine, University of Basel, Basel, Switzerland

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Alexander Kutz Medical University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland
Faculty of Medicine, University of Basel, Basel, Switzerland

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Beat Mueller Medical University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland
Faculty of Medicine, University of Basel, Basel, Switzerland

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Philipp Schuetz Medical University Department of Medicine, Kantonsspital Aarau, Aarau, Switzerland
Faculty of Medicine, University of Basel, Basel, Switzerland

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blood pressure and tissue perfusion, occurs in sepsis and in septic shock resulting in activation of counteracting mediators ( 13 , 14 ). This includes activation of the arginine vasopressin (AVP) on the hypothalamic–pituitary–adrenal (HPA) axis ( 15

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Xiaonan Guo Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Wenjing Hu Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Xiaorui Lyu Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Hanyuan Xu Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Huijuan Zhu Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Hui Pan Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Linjie Wang Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Hongbo Yang Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Fengying Gong Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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of arginine and proline metabolism ( 42 , 43 ). Besides, arginine, the component of arginine vasopressin (AVP), plays a pivotal role in regulating blood pressure. It has been demonstrated that abnormal AVP levels could severely promote portal

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Signe Frøssing Department of Internal Medicine, Center of Endocrinology and Metabolism, Herlev Gentofte Hospital, Copenhagen, Denmark
Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark

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Malin Nylander Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
Department of Obstetrics & Gynecology, Herlev Gentofte Hospital, Copenhagen, Denmark

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Caroline Kistorp Department of Internal Medicine, Center of Endocrinology and Metabolism, Herlev Gentofte Hospital, Copenhagen, Denmark
Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark

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Sven O Skouby Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark
Department of Obstetrics & Gynecology, Herlev Gentofte Hospital, Copenhagen, Denmark

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Jens Faber Department of Internal Medicine, Center of Endocrinology and Metabolism, Herlev Gentofte Hospital, Copenhagen, Denmark
Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark

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.109.909663 12 Asferg CL Andersen UB Linneberg A Goetze JP Jeppesen JL. Copeptin, a surrogate marker for arginine vasopressin secretion, is associated with higher glucose and insulin concentrations but not higher blood pressure in

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Alberto Giacinto Ambrogio Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Massimiliano Andrioli Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Martina De Martin Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Francesco Cavagnini Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Francesca Pecori Giraldi Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano IRCCS, Milan, Italy
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

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Medicine and Biology 1998 449 251 – 276 . 10.1007/978-1-4615-4871-3_34 10026814 43 Saito M Tahara A Sugimoto T. 1-Desamino-8-D-arginine vasopressin (DDAVP) as an agonist on V 1B vasopressin receptor . Biochemical Pharmacology 1997

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Dirk Weismann Department of Internal Medicine I, Intensivcare Unit, University Hospital of Würzburg, Würzburg, Germany

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Andreas Schneider Department of Internal Medicine I, Intensivcare Unit, University Hospital of Würzburg, Würzburg, Germany

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Charlotte Höybye Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden
Department of Molecular Surgery and Medicine, Karolinska Institute, Stockholm, Sweden

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and arginine vasopressin dysregulation: mechanisms, clinical consequences, and management . Journal of the American Geriatrics Society 2006 54 345 – 353 . ( doi:10.1111/j.1532-5415.2005.00609.x ) 24 Nigro N Winzeler B Suter-Widmer I

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Clara Odilia Sailer Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland

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Sophia Julia Wiedemann Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Biomedicine, University of Basel, Basel, Switzerland

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Konrad Strauss Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany

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Ingeborg Schnyder Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland

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Wiebke Kristin Fenske Leipzig University Medical Center, Integrated Center for Research and Treatment Adiposity Diseases, Leipzig, Germany
Medical Department III, Endocrinology, Nephrology, Rheumatology, University Hospital of Leipzig, Leipzig, Germany

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Mirjam Christ-Crain Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland

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. ( https://doi.org/10.1038/ni.3659 ) 19 Palin K Moreau ML Sauvant J Orcel H Nadjar A Duvoid-Guillou A Dudit J Rabié A Moos F . Interleukin-6 activates arginine vasopressin neurons in the supraoptic nucleus during immune challenge in

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I M A A van Roessel Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

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J P de Graaf Dutch Pituitary Foundation, Nijkerk, The Netherlands
Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Endo-ERN European Reference Network on Rare endocrine conditions

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N R Biermasz Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Endo-ERN European Reference Network on Rare endocrine conditions

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E Charmandari Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, Aghia Sophia Children's Hospital, Athens, Greece
Division of Endocrinology and Metabolism, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

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H M van Santen Department of Pediatric Endocrinology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands

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, including arginine vasopressin deficiency (diabetes insipidus (DI)) with adipsia) ( 6 , 7 , 8 , 9 ). Disturbed hunger and satiety feelings in combination with decreased energy expenditure can result in morbid obesity, with the clinical picture being very

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Arno Téblick Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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Ilse Vanhorebeek Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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Inge Derese Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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An Jacobs Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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Renata Haghedooren Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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Sofie Maebe Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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Gerdien A Zeilmaker-Roest Department of Neonatal & Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC – Sophia Children’s Hospital, Rotterdam, the Netherlands

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Enno D Wildschut Department of Neonatal & Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC – Sophia Children’s Hospital, Rotterdam, the Netherlands

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Lies Langouche Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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Greet Van den Berghe Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

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of the ACTH precursor, pro-opiomelanocortin (POMC) ( 1 ). Results from our mechanistic animal study suggested that during sepsis-induced critical illness, preserved hypothalamic corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP

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