Simon Schimmack
Simon Schimmack
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Yongchao Yang
Yongchao Yang
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
Department of Burns and Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
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Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
Department of Burns and Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
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Klaus Felix
Klaus Felix
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Markus Herbst
Markus Herbst
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Yixiong Li
Yixiong Li
Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
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Miriam Schenk
Miriam Schenk
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Frank Bergmann
Frank Bergmann
Institute of Pathology, Heidelberg University, Heidelberg, Germany
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Thilo Hackert
Thilo Hackert
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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Oliver Strobel
Oliver Strobel
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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acute-phase protein which is produced mainly in the liver and rarely in atherosclerotic lesions, kidney, neurons and alveolar macrophages ( 7 , 8 , 9 ). CRP synthesis is triggered largely through secretion of interleukin 6 (IL-6) from macrophages and T
Zeting Li
Zeting Li
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Ling Pei
Ling Pei
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Huangmeng Xiao
Huangmeng Xiao
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Nan Chen
Nan Chen
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Fenghua Lai
Fenghua Lai
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Shufang Yue
Shufang Yue
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Changliu Xu
Changliu Xu
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Yanbing Li
Yanbing Li
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Haipeng Xiao
Haipeng Xiao
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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Xiaopei Cao
Xiaopei Cao
Department of Endocrinology, Sun Yat-sen University First Affiliated Hospital, Guangzhou, China
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secretion is increased by inflammatory stimuli in an IL-6-dependent manner, leading to hyperinsulinemia and blood glucose lowering . Diabetes 2014 63 3221 – 3229 . ( https://doi.org/10.2337/db14-0100 ) 34 Timper K Dalmas E Dror E Rutti S Thienel
Linfei Yang
Linfei Yang
Center for Medical Experiments, The Third Xiangya Hospital, Central South University, Changsha, China
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Xiao Yu
Xiao Yu
Department of General Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
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Yongchao Yang
Yongchao Yang
Department of Burns and Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China
European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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European Pancreas Center, Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany
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). Signal transducer and activator of transcription 3 (STAT3) is a crucial regulator of gene expression in response to signalling of the glycoprotein 130 (gp130) family of cytokines that includes IL-6 ( 13 ). The STAT3 signalling pathway plays a key role in
Bushra Shahida
Bushra Shahida
Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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Tereza Planck
Tereza Planck
Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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Tania Singh
Tania Singh
Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
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Peter Åsman
Peter Åsman
Department of Clinical Sciences Malmö, Ophthalmology, Lund University, Malmö, Sweden
Department of Ophthalmology, Skåne University Hospital, Malmö, Sweden
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Department of Ophthalmology, Skåne University Hospital, Malmö, Sweden
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Mikael Lantz
Mikael Lantz
Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University, Malmö, Sweden
Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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Department of Diabetes & Endocrinology, Skåne University Hospital, Malmö, Sweden
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) induced the expression of the inflammatory markers PTGS2 , IL-1B , and IL-6 in orbital fibroblasts from patients with GO. Furthermore, the expression of these genes and adipogenesis of orbital fibroblasts was decreased by the treatment with simvastatin
Xuan Luo
Xuan Luo
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Tingting Zheng
Tingting Zheng
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Chaoming Mao
Chaoming Mao
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Institute of Oncology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Xin Dong
Xin Dong
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Xiao Mou
Xiao Mou
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Chengcheng Xu
Chengcheng Xu
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Qingyan Lu
Qingyan Lu
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Baocui Liu
Baocui Liu
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, China
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Shengjun Wang
Shengjun Wang
Department of Laboratory Immunology, Jiangsu University School of Medicine, Zhenjiang, China
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Yichuan Xiao
Yichuan Xiao
Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
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, 13 ), the pathogenesis of HT remains unclear. During HT pathogenesis, the cytokine IL-1 has been reported to stimulate thyroid follicular cell (TFC) proliferation and produce other pro-inflammatory cytokines, such as IL-6 and IL-8, which in turn
Yongping Liu
Yongping Liu
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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Shuo Wang
Shuo Wang
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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Qingling Guo
Qingling Guo
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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Yongze Li
Yongze Li
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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Jing Qin
Jing Qin
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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Na Zhao
Na Zhao
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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Yushu Li
Yushu Li
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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Zhongyan Shan
Zhongyan Shan
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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Weiping Teng
Weiping Teng
Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, People’s Republic of China
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environmental components ( 6 ). However, the underlying pathogenesis of HT is still unclear ( 7 ). Recent studies have revealed that elevated serum IL-17 and Th17 levels in HT patients were correlated with pathogenesis ( 8 , 9 , 10 ). Moreover, Th17 cells were
Milica Popovic
Milica Popovic
Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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Fahim Ebrahimi
Fahim Ebrahimi
Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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Sandrine Andrea Urwyler
Sandrine Andrea Urwyler
Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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Marc Yves Donath
Marc Yves Donath
Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Biomedicine, University of Basel, Basel, Switzerland
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Department of Biomedicine, University of Basel, Basel, Switzerland
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Mirjam Christ-Crain
Mirjam Christ-Crain
Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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Department of Clinical Research, University of Basel and University Hospital Basel, Basel, Switzerland
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elevated levels of C-reactive protein (CRP) ( 8 , 21 , 22 , 23 ). Elevated CRP levels in patients with metabolic syndrome result from a chronic activation of the IL-1 system, a key cytokine stimulated by metabolic stress ( 24 ). Chronic low
Xiao Zong
Xiao Zong
Department of Vascular & Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Institution of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Institution of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Qin Fan
Qin Fan
Department of Vascular & Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Institution of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Institution of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Hang Zhang
Hang Zhang
Department of Vascular & Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Institution of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Institution of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Qian Yang
Qian Yang
Department of Vascular & Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Institution of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Institution of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Hongyang Xie
Hongyang Xie
Department of Vascular & Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Institution of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Institution of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Qiujing Chen
Qiujing Chen
Institution of Cardiovascular Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Ruiyan Zhang
Ruiyan Zhang
Department of Vascular & Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Rong Tao
Rong Tao
Department of Vascular & Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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highest sST2 tertile. However, the role of the IL33-ST2 pathway in liver metabolism remains controversial ( 33 , 34 ), and the involvement of sST2 in glucose and lipid metabolism abnormalities needs to be further studied. On the other hand, our present
M A Webb
M A Webb
NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, University Hospitals of Leicester, Leicester General Hospital, Leicester, UK
The Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, UK
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The Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, UK
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H Mani
H Mani
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
Department of Diabetes and Endocrinology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK
Diabetes and Endocrinology Department, Kettering General Hospital NHS Foundation Trust, Kettering, UK
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Department of Diabetes and Endocrinology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK
Diabetes and Endocrinology Department, Kettering General Hospital NHS Foundation Trust, Kettering, UK
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S J Robertson
S J Robertson
The Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, UK
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H L Waller
H L Waller
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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D R Webb
D R Webb
NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, University Hospitals of Leicester, Leicester General Hospital, Leicester, UK
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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C L Edwardson
C L Edwardson
NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, University Hospitals of Leicester, Leicester General Hospital, Leicester, UK
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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D H Bodicoat
D H Bodicoat
NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, University Hospitals of Leicester, Leicester General Hospital, Leicester, UK
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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T Yates
T Yates
NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, University Hospitals of Leicester, Leicester General Hospital, Leicester, UK
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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K Khunti
K Khunti
NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, University Hospitals of Leicester, Leicester General Hospital, Leicester, UK
The Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, UK
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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The Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, UK
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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M J Davies
M J Davies
NIHR Leicester-Loughborough Diet, Lifestyle and Physical Activity Biomedical Research Unit, University Hospitals of Leicester, Leicester General Hospital, Leicester, UK
The Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, UK
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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The Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester General Hospital, Leicester, UK
Diabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester, UK
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Mean value at BL Mean value at 6 months P value Age, years 34.8 Body mass index, kg/m 2 32.5 (0.89) 32.2 (0.91) 0.067 Average daily steps (1000s) 6.34 (0.27) 6.69 (0.32) 0.121 IL6, ng/L 6.07 (0
Zhiwei Zhang
Zhiwei Zhang
Department of Obstetrics and Gynecology, Liaocheng People’s Hospital, Liaocheng, Shandong, China
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Hui Zhao
Hui Zhao
Department of Obstetrics and Gynecology, Liaocheng People’s Hospital, Liaocheng, Shandong, China
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Aixia Wang
Aixia Wang
Department of Obstetrics and Gynecology, Liaocheng People’s Hospital, Liaocheng, Shandong, China
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interleukin-1β (IL-1β), IL-6 and tumor necrotic factor α (TNF-α) levels in the serum. As a mechanistic study, we also examined the link between the AMPK signaling pathway and oleuropein treatment. The results of the study could provide insights into the
