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capacity, bone health, several cardiovascular risk factors and quality of life ( 3 , 4 , 5 ). Pitfalls of GH and IGF-I assays and the recent upward adjustment of the normative IGF-I SD scores for the iSYS IGF-I assay make early recognition of AGHD
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one of the most influential regulators of growth hormone (GH) secretion and action, with different mechanisms ( 2 ). Androgens and estrogens exert opposite endocrine-mediated effects on insulin-like growth factor (IGF)-I production and metabolic
Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, USA
Pituitary Center, Oregon Health & Science University, Portland, Oregon, USA
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Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, USA
Pituitary Center, Oregon Health & Science University, Portland, Oregon, USA
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Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon, USA
Pituitary Center, Oregon Health & Science University, Portland, Oregon, USA
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comorbidities related to the tumor itself (e.g. headache, oculomotor never palsy or hypopituitarism) or to GH and insulin-like growth factor-1 (IGF-1) excess (arthralgia, morphologic changes, or obstructive sleep apnea (OSA), cardiovascular disease, and
Université Paris Diderot, Sorbonne Paris Cité, Paris, France
Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 1141, DHU PROTECT, Paris, France
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Université Paris Diderot, Sorbonne Paris Cité, Paris, France
Institut National de la Santé et de la Recherche Médicale (INSERM), Unité 1141, DHU PROTECT, Paris, France
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involving the growth hormone (GH)-insulin-like growth factor-I (IGF-I) axis, thyroid function, hypercortisolemia, hypogonadotropic hypogonadism and the levels of several adipokines and gut peptides, such as ghrelin and peptide YY ( 2 ). The
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Department of Health & Life Sciences, Charles R. Drew University of Medicine and Science, Los Angeles, California, USA
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
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Department of Health & Life Sciences, Charles R. Drew University of Medicine and Science, Los Angeles, California, USA
Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
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as ( 1 ) MYOD, ( 2 ) MYOG, ( 3 ) MYC type II, ( 4 ) muscle troponin I and troponin T, ( 5 ) MYH1 (myosin heavy chain I); and growth factors such as ( 6 ) IGF1 and 2, ( 7 ) FGF1 and 2, ( 8 ) BMP4 and ( 9 ) MMP9. Furthermore, exposure of satellite cells
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of the impact of insulin-like growth factor I (IGF-I) levels on adherence over the follow-up period. Demographic, auxological and diagnostic data were obtained from medical charts. All data were collected both retrospectively and prospectively. In
PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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PhyMedExp, Université de Montpellier, INSERM, CNRS, Montpellier, France
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CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
Institut de Génomique Fonctionnelle, CNRS UMR 5203/INSERM U661/Université Montpellier, Montpellier, France
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CIC INSERM 1411, Hôpital Gui de Chauliac, CHU Montpellier, Montpellier Cedex 5, France
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Département de Biochimie, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département d’Urgence et Post-Urgence Psychiatrique, Hôpital Lapeyronie, CHU Montpellier, Montpellier, France
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Département Endocrinologie, Nutrition, Diabète, Equipe Nutrition, Diabète, CHU Montpellier, Montpellier, France
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products; IGF-1, insulin-like growth factor-1; OC, osteocalcin; PINP, procollagen type I N-terminal propeptide; Z-score, the number of s.d. above or below the mean for the patient’s age, sex and ethnicity. Bold indicates statistical significance
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Introduction Growth hormone (GH) and insulin-like growth factor-I (IGF1) are anabolic hormones which influence bone metabolism through the modulation of several signaling pathways ( 1 ). In vitro studies showed that GH enhances the
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Department of Physical Therapy and Post-Graduate Program in Health Science, Federal University of Sergipe, The GREAT Group (GRupo de Estudos em ATividade física), Sergipe, Brazil
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Department of Physical Therapy and Post-Graduate Program in Health Science, Federal University of Sergipe, The GREAT Group (GRupo de Estudos em ATividade física), Sergipe, Brazil
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Department of Physical Therapy and Post-Graduate Program in Health Science, Federal University of Sergipe, The GREAT Group (GRupo de Estudos em ATividade física), Sergipe, Brazil
Department of Physical Therapy and Neuroscience, Wertheims’ College of Nursing and Health Science, Florida International University, Miami, Florida, USA
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, OMIM n. 612781), resulting in low serum GH and IGF-I throughout their life ( 12 ). Although these individuals are severely short, with reduced lean body mass and increased fat percentage, they perform vigorous daily physical activities such as pottery
Department of Pediatrics, Aarhus University Hospital, Aarhus N, Denmark
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Department of Molecular Medicine, Aarhus University Hospital, Aarhus N, Denmark
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.4 3.9 ± 1.6 <0.0001 SHBG (nmol/L) 31.6 ± 13.8 24.5 ± 10.6 0.001 30.3 ± 9.6 0.8 Hemoglobin (mmol/L) 8.7 ± 0.6 9.0 ± 0.6 0.05 9.6 ± 0.6 0.001 IGF-I (µg/L) 163 ± 51 178 ± 47 0.03 165 ± 54 0.9 IGFBP-3