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Lukas Ochsner Ridder Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark

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Agnethe Berglund Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Department of Clinical Genetics and Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark

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Kirstine Stochholm Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark

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Simon Chang Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
Unit for Thrombosis Research, Hospital of South West Jutland and University of Southern Denmark, Esbjerg, Denmark

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Claus H Gravholt Department of Endocrinology and Internal Medicine and Medical Research Laboratories, Aarhus University Hospital, Aarhus, Denmark
Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark
Unit for Thrombosis Research, Hospital of South West Jutland and University of Southern Denmark, Esbjerg, Denmark

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explained by an increased incidence of diseases of the circulatory system ( 12 , 66 , 67 ). For instance, men with KS present an up to eight-fold increased risk of death due to venous thromboembolisms (VTEs) compared to the male background population ( 68

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Carina Ankarberg-Lindgren Department of Pediatrics, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

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Aneta Gawlik Department of Pediatrics and Pediatric Endocrinology, Medical University of Silesia, School of Medicine, Katowice, Poland

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Berit Kriström Department of Clinical Sciences/Pediatrics, Umeå University, Umeå, Sweden

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Laura Mazzanti Pediatric Endocrinology and Rare Disease Unit, Department of Medical and Surgical Science, University of Bologna, Bologna, Italy

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Elisabeth J Ruijgrok Department of Pharmacy, Erasmus Medical Center – Sophia Children’s Hospital, University Medical Center Rotterdam, Rotterdam, the Netherlands

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Theo C J Sas Department of Pediatric Endocrinology, Sophia Children’s Hospital, University Medical Center Rotterdam, Rotterdam, the Netherlands
Diabeter, National Diabetes Care and Research Center, Rotterdam, the Netherlands

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.1136/archdischild-2016-311372 4 Scarabin PY Oger E Plu-Bureau G & EStrogen and THromboEmbolism Risk Study Group . Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk . Lancet 2003 362 428 – 432

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Wang Chengji College of Physical Education, Chaohu University, Anhui Province, China

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Fan Xianjin College of Physical Education, Chaohu University, Anhui Province, China

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venous thromboembolism ( 6 , 7 , 8 , 9 ). Although reducing fasting plasma glucose levels to normal is seen as a way to prevent negative cardiovascular outcomes, such as myocardial infarction or stroke ( 10 ), the most recent study with insulin

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Panagiotis Anagnostis Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Irene Lambrinoudaki 2nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Medical School, Athens, Greece

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John C Stevenson National Heart and Lung Institute, Imperial College London, Royal Brompton and Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London, UK

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Dimitrios G Goulis Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

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transdermal route ( 6 , 7 ). Nevertheless, the latter does not affect the coagulation system and is not associated with an increased risk of venous thromboembolism (VTE) in contrast to the oral regimen ( 37 , 38 ). MHT may exert either a slight reduction

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Cecilia Lundin Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden

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Agota Malmborg Obstetrics and Gynaecology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

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Julia Slezak Clinical Chemistry, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

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Kristina Gemzell Danielsson Department of Women’s and Children’s Health, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden

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Marie Bixo Department of Clinical Science, Obstetrics and Gynaecology, Umeå University, Umeå, Sweden

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Hanna Bengtsdotter Department of Obstetrics and Gynaecology, Örebro University, Örebro, Sweden

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Lena Marions Department of Clinical Science and Education, Karolinska Institutet Södersjukhuset, Stockholm, Sweden

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Ingela Lindh Department of Obstetrics and Gynaecology, Sahlgrenska Academy at Gothenburg University, Sahlgrenska University Hospital, Gothenburg, Sweden

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Elvar Theodorsson Clinical Chemistry, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

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Mats Hammar Obstetrics and Gynaecology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden

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Inger Sundström-Poromaa Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden

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confirm they would use barrier contraceptives or copper intrauterine device (IUD) while participating. No study-specific exclusion criteria were used. As in clinical routine, women with prior history of venous thromboembolism, known predisposition for

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Anna Sjöström Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden

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Susanne Rysz Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden
Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

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Henrik Sjöström Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Center for Neurology, Academic Specialist Center, Stockholm, Sweden

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Charlotte Höybye Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden

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presented with low levels of sodium and suspected SIADH, the potential high release of AVP could be a part of the procoagulant state of COVID-19 further impaired by hyperosmolality which also increases the risk of venous thromboembolism ( 31 ). Case reports

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Mette Bøgehave Department of Clinical Biochemistry, Hospital South West Jutland, University Hospital of Southern Denmark, Esbjerg, Denmark
Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Denmark

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Dorte Glintborg Department of Endocrinology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark
OPEN, Open Patient data Explorative Network, Odense University Hospital, Region of Southern Denmark, Odense, Denmark

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Jørgen Brodersen Gram Department of Clinical Biochemistry, Hospital South West Jutland, University Hospital of Southern Denmark, Esbjerg, Denmark
Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Denmark

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Else-Marie Bladbjerg Department of Clinical Biochemistry, Hospital South West Jutland, University Hospital of Southern Denmark, Esbjerg, Denmark
Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Denmark

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Marianne Skovsager Andersen Department of Endocrinology, Odense University Hospital, Odense, Denmark
Department of Clinical Research, University of Southern Denmark, Odense, Denmark

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Johannes Jakobsen Sidelmann Department of Clinical Biochemistry, Hospital South West Jutland, University Hospital of Southern Denmark, Esbjerg, Denmark
Unit for Thrombosis Research, Department of Regional Health Research, University of Southern Denmark, Denmark

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. ( https://doi.org/10.1111/cen.13084 ) 15 Walker RF Zakai NA MacLehose RF Cowan LT Adam TJ Alonso A Lutsey PL . Association of testosterone therapy with risk of venous thromboembolism among men with and without hypogonadism . JAMA Internal

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Orwa Dandash Department of Psychiatry, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia

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James Allebone Department of Psychiatry, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia

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Adam Mirabelli Department of Psychiatry, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia

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Nicholas Russell Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia

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Mathis Grossmann Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia

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Andrea Gogos Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia
Department of Florey Institute, University of Melbourne, Parkville, Victoria, Australia

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Richard A Kanaan Department of Psychiatry, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia

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venous thromboembolism (VTE); breast cancer; systolic blood pressure >160 or diastolic blood pressure >100; New York Heart Association class 3 or 4 angina or heart failure; stroke, transient ischemic attack, myocardial infarction, or angina within 12

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Bo Zhu Department of Obstetrics and Gynecology, Assisted Reproduction Unit, Sir Run Run ShawHospital, Zhejiang University School of Medicine Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, Zhejiang, China
Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China

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Yumei Chen Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China

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Fang Xu Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China

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Xiaolu Shen Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China

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Xuanyu Chen Department of Gynecology and Obstetrics, Wenzhou People’s Hospital, Wenzhou Women and Children Health, Wenzhou, Zhejiang, China

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Jieqiang Lv Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

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Songying Zhang Department of Obstetrics and Gynecology, Assisted Reproduction Unit, Sir Run Run ShawHospital, Zhejiang University School of Medicine Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Hangzhou, Zhejiang, China

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( 1 , 2 ). Women with PCOS have increased risk for type 2 diabetes (T2DM), obesity, infertility, obstetrical complications, mood disorders, and endometrial cancer, which may also increase the risk of cardiovascular diseases, venous thromboembolism

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Lauren R Cirrincione Department of Pharmacy, University of Washington, Seattle, Washington, USA

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Bridgit O Crews Department of Pathology and Laboratory Medicine, University of California Irvine, Orange, California, USA

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Jane A Dickerson Department of Laboratories, Seattle Children's Hospital, Seattle, Washington, USA

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Matthew D Krasowski Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA

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Jessica Rongitsch Internal Medicine, Capitol Hill Medical, Seattle, Washington, USA

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Katherine L Imborek Department of Family Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA

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Zil Goldstein Department of Medicine, Callen-Lorde Community Health Center, New York, New York, USA
CUNY Graduate School of Public Health and Health Policy, New York, New York, USA

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Dina N Greene Washington Kaiser Permanente, Renton, Washington, USA
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA

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. Managing the risk of venous thromboembolism in transgender adults undergoing hormone therapy . Journal of Blood Medicine 2019 10 209 – 216 . ( https://doi.org/10.2147/JBM.S166780 ) 17 Dancoine F Couplet G Buvat J Guittard C Marcolin G

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