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and associated metabolic conditions, such as insulin resistance ( 5 ), diabetes ( 6 ), hypercholesterolaemia ( 7 ), statins ( 8 ), abdominal fat ( 9 ), the sympathetic nervous system ( 10 , 11 ), and corticosteroid use ( 12 ). Glucocorticoids are a
Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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Laboratory of Diabetic Kidney Disease, Centre of Diabetes and Metabolism Research, West China Hospital of Sichuan University, Chengdu, Sichuan, China
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(ARB), statins and antihyperuricemic drug. The trajectories of eGFR decline and SUA change were evaluated using a simple linear model. Moreover, hyperuricemia was defined as SUA higher than 420 μmol/L in men and 360 μmol/L in women. Renal biopsy
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statins among the tertiles of ADA levels ( P for trend < 0.05). However, BMI, diastolic blood pressure (DBP), use of insulin secretagogues and dipeptidyl peptidase 4 (DPP-4) inhibitors, antihypertensive treatments, lipid profile, BUN level, and Cr level
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1c and UACR level increased, whereas the percentage of patients using metformin and eGFR decreased ( P for trend < 0.05). However, BMI, diastolic blood pressure (DBP), use of other antihyperglycemic treatments, antihypertensive treatments, statin
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as age, sex and blood pressure), medical history (such as diabetes duration, history of hypertension and smoking), prescription information (such as glucose-lowering therapies and statins treatments), and biochemical measurements. Glucose
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pressure; waist circumference; total cholesterol; high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol; glycated haemoglobin (HbA1c); triglycerides and the proportion of patients using statins. Statistics Summary
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statin medications, lipid profile or UA level ( P for trend >0.05). Table 1 Clinical characteristics of the study participants. Normally distributed values in the table are given as the mean ± s.d. , skewed distributed values are given as the
Department of Endocrinology, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway
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Medical Clinic, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway
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Department of Gastroenterology, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway
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K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Trondheim, Norway
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Medical Clinic, Trondheim University Hospital (St Olavs Hospital), Trondheim, Norway
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of drugs prescribed to treat hypercholesterolemia and hypertension (e.g. statins, ACE inhibitors, ARBs, Ca channel blockers) was more common in the diabetes group. About 30 and 25% were treated with statins and antihypertensives, respectively. A
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, infections, particularly middle ear infections, trauma or surgery, and possible drug interactions with dexamethasone (i.e. antidiabetic, anticonvulsants, oral anticoagulants, antihypertensives, antidepressants, NSAID, and statins), as well as blood glucose
Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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biguanides, dipeptidyl peptidase 4 inhibitors, sulfonylureas, thiazolidinediones, calcium channel blockers, statin, and aspirin. Propensity score matched method In consideration that the baseline characteristics might be imbalanced between insulin