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Hiren Patt, Katrin Koehler, Sailesh Lodha, Swati Jadhav, Chaitanya Yerawar, Angela Huebner, Kunal Thakkar, Sneha Arya, Sandhya Nair, Manjunath Goroshi, Hosahithlu Ganesh, Vijaya Sarathi, Anurag Lila, Tushar Bandgar and Nalini Shah

–phenotype correlation. Herein, we present our series of eight TAS patients from Western India. Additionally, we did systematic review of the published literature, with the aim of analyzing phenotypic and genotypic spectrum of TAS patients worldwide. Patients and

Open access

Yosep Chong, Soon-Jin Ji, Chang Suk Kang and Eun Jung Lee

use LBP alone or whether LBP should be applied in combination with CS are aspects that are not clear. In this study, we performed a systematic review and meta-analysis of the comparative studies of LBP and CS, mainly on ThinPrep and SurePath methods

Open access

N Bergmann, F Gyntelberg and J Faber

, these parameters fluctuate, have great inter-individual variability, and reflect mostly acute stress-load (6) . For these reasons, we will not consider the physiological stress-measures as markers of chronic psychosocial stress in this review. Others

Open access

Isabel M Abreu, Eva Lau, Bernardo de Sousa Pinto and Davide Carvalho

overall cardiovascular risk. Materials and methods Search strategy For the systematic review, a comprehensive search of the Medline database was performed up to September 8th, 2015, using the following query: (thyroid* or hypothyroid*) and

Open access

Liza Haqq, James McFarlane, Gudrun Dieberg and Neil Smart

insulin-induced metabolic syndrome are also the risk factors that can predispose women with PCOS to cardiovascular disease and type 2 diabetes mellitus (6) . A systematic review was completed in 2011 by Harrison et al . (13) , but presumably as

Open access

Weixi Wang, Rulai Han, Lei Ye, Jing Xie, Bei Tao, Fukang Sun, Ran Zhuo, Xi Chen, Xiaxing Deng, Cong Ye, Hongyan Zhao and Shu Wang

clarified. In the current study, we described a MEN1 family with ACC in a cohort of MEN1 patients. Furthermore, we explored the preliminary roles of MEN1 in ACC tumorigenesis and performed a literature review of previously reported cases. Subjects

Open access

Nafiye Helvaci, Erdem Karabulut, Ahmet Ugur Demir and Bulent Okan Yildiz

reported increased prevalence of OSA in adolescent girls with PCOS compared to age- and BMI-matched controls (16/28 (57%) vs 4/28 (14.3%), P  < 0.01) ( 15 ). This was a retrospective chart review study and study population included adolescent girls with

Open access

Cheng Han Ng, Yip Han Chin, Marcus Hon Qin Tan, Jun Xuan Ng, Samantha Peiling Yang, Jolene Jiayu Kiew and Chin Meng Khoo

Purpose: Primary hyperparathyroidism (PHPT) is common condition, affecting people of all ages and is mainly treated with parathyroidectomy. Cinacalcet has been widely used in secondary or tertiary hyperparathyroidism, but the use of cinacalcet in PHPT is less clear.

Methods: Searches were conducted in Medline and Embase for cinacalcet use in PHPT from induction to 10th April 2020. Articles and conferences abstracts describing the use of cinacalcet for PHPT in prospective or retrospective cohorts and randomized controlled trials restricted to English Language only. We initially identified 1301 abstracts. Each article went extraction by two blinded authors on a structured proforma. Continuous outcomes were pooled with weight mean difference (WMD). Quality of included articles was assessed with Newcastle Ottwa Scale and Cochrane risk of Bias 2.0.

Results: 28 articles were included. Normalization rate of serum calcium levels was reported at 90% (CI: 0.82 to 0.96). Serum levels of calcium and PTH levels were significantly reduced (calcium, WMD: 1.647 (CI: -1.922 to -1.371; PTH, WMD: -31.218, CI: -41.671 to -20.765) and phosphate levels significantly increased (WMD: 0.498, CI: 0.400 to 0.596) after cinacalcet therapy The higher the baseline calcium levels, the greater calcium reduction with cinacalcet treatment. Age and gender did not modify the effect of cinacalcet on serum calcium levels.

Conclusion: The results from the meta-analysis support the use of cinacalcet as an alternative or bridging therapy to treat hypercalcemia in people with PHPT.

Open access

Aaron Lerner, Patricia Jeremias and Torsten Matthias

become the most common autoimmune disease. Its prevalence is 0.8% when estimated from a review of published articles, 4.6% when estimated biochemically from the National Health and Nutrition Examination Survey and >5% when estimated from cytology of

Open access

Maria Angela D'amico, Barbara Ghinassi, Pascal Izzicupo, Lamberto Manzoli and A Di Baldassarre

catestatin was more important in females, indicating that catestatin may contribute to sex differences in endogenous vascular tone and influence the complex predisposition to hypertension. Conclusions This review summarizes the knowledge about CgA and