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Targeting β-cell dedifferentiation and transdifferentiation: opportunities and challenges

Wenrui Wang

Wenrui Wang Department of Endocrinology, The Second Hospital of Jilin University, Changchun, People’s Republic of China

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Chuan Zhang

Chuan Zhang Department of Endocrinology, The Second Hospital of Jilin University, Changchun, People’s Republic of China

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, and valine. These three amino acids, as well as tyrosine and phenylalanine, were increased while glycine was decreased in obese hyperinsulinemic patients ( 14 , 38 , 39 ). Elevated plasma levels of BCAA and aromatic amino acids (tyrosine and