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Aaron Lerner, Patricia Jeremias, and Torsten Matthias

) not less important is the transcriptomic, proteinomic and the metabolomics changes induced by the gut microbes, being direct messengers between the bugs and us. Changes in microbiota and short chain fatty acids production are clearly related to the

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Florian W Kiefer

the BAT-derived 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME), which is increased in response to cold exposure and promotes BAT activation in a feedforward mechanism ( 82 ). In search for new BAT biomarkers, targeted metabolomics recently showed

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K Amrein, A Papinutti, E Mathew, G Vila, and D Parekh

illness severity. Despite this, the current evidence for replacement therapy is compelling, but there remain unanswered questions, including adequate dosing strategies, the effect of critical illness on vitamin D metabolomics and the optimum target vitamin

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Elisabet Einarsdottir, Minna Pekkinen, Kaarel Krjutškov, Shintaro Katayama, Juha Kere, Outi Mäkitie, and Heli Viljakainen

activity in skeletal muscle and adipose tissue in patients with obesity and type 2 diabetes ( 23 , 24 , 25 ). In fact, mitochondrial dysfunction is suggested to precede the development of insulin resistance ( 26 , 27 ). In a recent metabolomics study

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Gudmundur Johannsson, Martin Bidlingmaier, Beverly M K Biller, Margaret Boguszewski, Felipe F Casanueva, Philippe Chanson, Peter E Clayton, Catherine S Choong, David Clemmons, Mehul Dattani, Jan Frystyk, Ken Ho, Andrew R Hoffman, Reiko Horikawa, Anders Juul, John J Kopchick, Xiaoping Luo, Sebastian Neggers, Irene Netchine, Daniel S Olsson, Sally Radovick, Ron Rosenfeld, Richard J Ross, Katharina Schilbach, Paulo Solberg, Christian Strasburger, Peter Trainer, Kevin C J Yuen, Kerstin Wickstrom, Jens O L Jorgensen, and on behalf of the Growth Hormone Research Society

, metabolomics and proteomics may facilitate selection of patients for therapy and improve prediction of clinical endpoints. Therefore, such approaches deserve further study, and the collection of suitable samples for biobanking should be considered in relevant

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Neil R Chappell, Beth Zhou, Amy K Schutt, William E Gibbons, and Chellakkan S Blesson

M Butz DE Haviland JA Porter WP Assadi-Porter FM . NMR metabolomics show evidence for mitochondrial oxidative stress in a mouse model of polycystic ovary syndrome . Journal of Proteome Research 2015 14 3284 – 3291 . ( https

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Ashley K Clift, Omar Faiz, Robert Goldin, John Martin, Harpreet Wasan, Marc-Olaf Liedke, Erik Schloericke, Anna Malczewska, Guido Rindi, Mark Kidd, Irvin M Modlin, and Andrea Frilling

effort has been expended in the development of novel approaches to rectify these shortcomings, such as PCR-based multi-analyte methods of assessing disease activity ( 19 ), analysis of miRNAs ( 5 ), metabolomic profiling ( 20 ) and prognostic nomograms

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Satoshi Higuchi, Hideki Ota, Takuya Ueda, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Fumitoshi Satoh, and Kei Takase

.ahj.2012.03.020 ) 22795284 10.1016/j.ahj.2012.03.020 23 Eisenhofer G Pacak K Huynh TT Qin N Bratslavsky G Linehan WM Mannelli M Friberg P Grebe SK Timmers HJ , et al . Catecholamine metabolomic and secretory phenotypes in phaeochromocytoma . Endocrine

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Michaela Keuper

). Other mediators between ATMΦ and adipocyte metabolism are metabolites. Upon activation, MΦ change their metabolomic profile ( 175 , 176 ), for example upon LPS activation, more lactate and pyruvate are released ( 176 ). Lactate and acetate have been

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T Grimmichova, M Haluzik, K Vondra, P Matucha, and M Hill

Trygg J . Chemometrics in metabolomics – a review in human disease diagnosis . Analytica Chimica Acta 2010 659 23 – 33 . ( ) 26 Wu P . Thyroid disease and diabetes . Clinical Diabetes 2000 18