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Zheng Chen Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China

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Haixia Zeng Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China

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Qiulan Huang Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China

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Cuiping Lin Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China

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Xuan Li Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China

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Shaohua Sun Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China

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Jian-ping Liu Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China

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diseases. Further, a study ( 13 ) has revealed that GPC4 levels are related to BMI and insulin sensitivity in humans, and that GPC4 directly binds to insulin receptors in the liver, skeletal muscle, and adipose tissue to enhance insulin signaling. The

Article Type:
Research Article
Collections:
Reproduction
DOI:
https://doi.org/10.1530/EC-23-0428
Volume/Issue:
Volume 13: Issue 3
Open access
Antonia Ertelt Equine Clinic, Free University of Berlin, Berlin, Germany

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Ann-Kristin Barton Equine Clinic, Free University of Berlin, Berlin, Germany

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Robert R Schmitz Equine Clinic, Free University of Berlin, Berlin, Germany

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Heidrun Gehlen Equine Clinic, Free University of Berlin, Berlin, Germany

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partly due to the predominance of stimulating β-receptors over antilipolytic α-adrenoreceptors, and lower insulin receptor affinity of mesenteric omental adipocytes respectively (27, 29) . In addition to differences in lipolysis at different

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-14-0038
Volume/Issue:
Volume 3: Issue 3
Open access
Ivar Følling Department of Endocrinology, Akershus University Hospital, Lørenskog, Norway
Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway

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Anna B Wennerstrøm Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway

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Tor J Eide Division of Laboratory Medicine, Department of Pathology, Oslo University Hospital, Oslo, Norway

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Hilde Loge Nilsen Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway

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catecholamines that inhibit insulin secretion and increase insulin resistance ( 14 ). In addition, we suggest that insulin-related molecules partly mimicking insulin may block the insulin receptor, and thereby contribute to hyperglycaemia. Secondly, rare cases

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0269
Volume/Issue:
Volume 10: Issue 8
Open access
Yao Chen Hangzhou Fuyang Women and Children Hospital, Hangzhou, China

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Shu-ying Fang Hangzhou Fuyang Women and Children Hospital, Hangzhou, China

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-stimulating hormone receptor ( FSHR ) gene polymorphisms, fat mass and obesity-associated ( FTO ) gene polymorphisms, insulin receptor ( IR ) and IR substrate ( IRS ) polymorphisms, vitamin D receptor ( VDR ) polymorphisms, methylenetetrahydrofolate reductase ( MTHFR

Article Type:
Review Article
DOI:
https://doi.org/10.1530/EC-18-0121
Volume/Issue:
Volume 7: Issue 5
Open access
Róża Aleksandrowicz Department of Prophylaxis of Metabolic Diseases, Bialystok, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland

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Marek Strączkowski Department of Prophylaxis of Metabolic Diseases, Bialystok, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Olsztyn, Poland

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also of great importance ( 2 ). Insulin interacts with receptors in the cell membrane. It thus stimulates signal transduction pathway. Insulin signaling molecules include insulin receptor substrate 1 (IRS1), phosphatidylinositol 3-kinase (PI3K), and

Article Type:
Review Article
Collections:
Bone and Mineral Metabolism
DOI:
https://doi.org/10.1530/EC-23-0023
Volume/Issue:
Volume 12: Issue 5
Open access
V Kenan Çelik Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey

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Sercan Kapancık Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey

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Turgut Kaçan Department of Medical Oncology, High Specialized Education and Research Hospital, Bursa, Turkey

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Selen Baloglu Kaçan Department of Internal Medicine, Afyonkarahisar State Hospital, Afyon, Turkey

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Serkan Kapancık Department of Biochemistry, Cumhuriyet University School of Medicine, Sivas, Turkey

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Hasan Kılıçgün Department of Nutrition and Dietetics, Health Science Faculty, University of Erzincan, Erzincan, Turkey

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shown that insulin receptor tyrosine kinase (IRTK) activity is influenced by physiological polyamines such as spermine which have similar effects with insulin ( 22 , 23 , 24 ). Thus, it is suggested that polyamines may play an important role in the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0137
Volume/Issue:
Volume 6: Issue 8
Open access
Ling Hu Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

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Ting Li Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

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Xiao-Ling Yin Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

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Yi Zou Department of Endocrinology, The Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China

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/insulin-like growth factor-1 pathway, thereby promoting the proliferation and differentiation of thyroid cells ( 18 ). The expression of the insulin receptor gene increases in the early stages of thyroid carcinoma ( 19 ). Insulin may promote cell proliferation through

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0398
Volume/Issue:
Volume 9: Issue 9
Open access
Yu Lin State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Yingying Zhang State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Lei Xu Maternal and Child Health Care Hospital of Dongchangfu District, Liaocheng, People’s Republic of China

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Wei Long State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Chunjian Shan State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Hongjuan Ding State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Lianghui You State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Chun Zhao State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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Zhonghua Shi State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China

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tyrosine-autophosphorylated insulin receptor, then activate insulin receptor substrate 1 (IRS1), and finally stimulates glucose transport via activating GLUT-4 ( 22 ). Increased insulin levels and GLUT-4 translocation promote glucose uptake and energy

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0584
Volume/Issue:
Volume 10: Issue 2
Open access
R Solomon-Zemler Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

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L Basel-Vanagaite Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Raphael Recanati Genetic Institute, Rabin Medical Center – Beilinson Hospital, Petach Tikva, Israel
Felsenstein Medical Research Center, Petach Tikva, Israel
Pediatric Genetics, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel

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D Steier Day Hospitalization Department, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel

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S Yakar David B. Kriser Dental Center, Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, New York, USA

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E Mel Jesse Z. and Sara Lea Shafer Institute for Endocrinology and Diabetes, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel

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M Phillip Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Jesse Z. and Sara Lea Shafer Institute for Endocrinology and Diabetes, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel

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L Bazak Raphael Recanati Genetic Institute, Rabin Medical Center – Beilinson Hospital, Petach Tikva, Israel

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D Bercovich Tel-Hai College, Tel-Hai, Israel

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H Werner Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Shalom and VardaYoran Institute for Human Genome Research, Tel Aviv University, Tel Aviv, Israel

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L de Vries Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Jesse Z. and Sara Lea Shafer Institute for Endocrinology and Diabetes, Schneider Children’s Medical Center of Israel, Petach Tikva, Israel

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receptors could result in a high content of hybrid receptors, composed of one αβ IGF1R hemireceptor linked to one αβ insulin receptor hemireceptor. Hybrid receptors containing the IR-B isoform are expressed predominantly in muscle and adipose tissue ( 29

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0038
Volume/Issue:
Volume 6: Issue 6
Open access
Yusaku Mori Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Department of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Shinagawa, Tokyo, Japan

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Eunhyoung Ko Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Rudolf Furrer Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Linda C Qu Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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Stuart C Wiber Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

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I George Fantus Departments of Medicine and Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
Division of Endocrinology and Metabolism, Leadership Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada

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Mario Thevis Center for Preventive Doping Research and Institute of Biochemistry, German Sport University Cologne, Cologne, Germany

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Alan Medline Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Ontario, Canada
Department of Pathology, Humber River Regional Hospital, Toronto, Ontario, Canada

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Adria Giacca Departments of Physiology and Medicine, Institute of Medical Science, Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada

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that new concentrated glargine and biosimilar glargine would contribute to increasing the number of patients treated with glargine, the potential cancer-promoting effect of glargine requires more detailed investigation. Insulin receptor (IR) and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0358
Volume/Issue:
Volume 7: Issue 5
Open access