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the mitochondrial outer membrane Na + /Ca2 + transporter Ncx3, thereby stabilizing mitochondrial calcium flux and alleviating cellular damage caused by hypoxia ( 34 ). Deleting AKAP1 increases mitochondrial ROS production and aggravates myocardial
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-adipocytes were seeded in XF24 cell culture plates (Seahorse Biosciences, North Billerica, MA), transfected, and differentiated as previously described ( 33 ). Oxygen consumption rate (OCR) of differentiated cells was assessed using an XF24 Extracellular Flux
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reabsorption by paracellular flux and potassium secretion by the renal outer medullary K + channels ( 13 ). Three homologous subunits share 30–40% identity, and each one comprises an extracellular loop, two transmembrane domains and a short intracellular N
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vascular inflammation and increased proinflammatory cytokines ( 35 ). In diabetes, PKC is activated by advanced glycation end (AGE) products and polyol pathway flux ( 36 ). Also, chronic hyperglycemia stimulates synthesis of DAG and activates DAG
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is located within the last intracellular loop, and results of functional analyses revealed normal transcription activity in an Erg-Luc assay but decreased calcium mobilization activity (72% of WT) in an aequorin-based Ca 2+ flux assay. Its expression
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