Min Li
Min Li
Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
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Ying Chen
Ying Chen
Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
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Jingjing Jiang
Jingjing Jiang
Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
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Yan Lu
Yan Lu
Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
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Zhiyi Song
Zhiyi Song
Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Shengjie Zhang
Shengjie Zhang
CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai, China
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Chao Sun
Chao Sun
CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai, China
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Hao Ying
Hao Ying
CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai, China
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Xiaofang Fan
Xiaofang Fan
Department of Endocrinology and Metabolism, Minhang Branch, Zhongshan Hospital, Central Hospital of Minhang District, Shanghai Minhang Hospital, Fudan University, Shanghai, China
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Yuping Song
Yuping Song
Department of Endocrinology and Metabolism, Minhang Branch, Zhongshan Hospital, Central Hospital of Minhang District, Shanghai Minhang Hospital, Fudan University, Shanghai, China
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Jialin Yang
Jialin Yang
Department of Endocrinology and Metabolism, Minhang Branch, Zhongshan Hospital, Central Hospital of Minhang District, Shanghai Minhang Hospital, Fudan University, Shanghai, China
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Lin Zhao
Lin Zhao
Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China
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Objective
Recent studies have shown that neuregulin 4 (Nrg4), a member of the epidermal growth factor (EGF) family of extracellular ligands, plays an important role in the prevention of obesity, insulin resistance and nonalcoholic fatty liver disease (NAFLD). Considering that thyroid hormone (TH) has profound effects on whole-body energy metabolism, we speculate that circulating Nrg4 levels might be altered in patients with hyperthyroidism.
Design and methods
A total of 129 hyperthyroid patients and 100 healthy subjects were recruited. Of them, 39 hyperthyroid patients received thionamide treatment for 3 months until euthyroidism. Serum Nrg4 levels were determined using the ELISA method. To further confirm the relationship between TH and Nrg4, C57BL/6 mice were treated with T3 and quantitative real-time PCR was performed to detect Nrg4 gene expression.
Results
Serum Nrg4 levels were significantly elevated in hyperthyroid patients as compared with normal controls (3.84 ± 1.63 vs 2.21 ± 1.04 ng/mL, P < 0.001). After achieving euthyroidism by thionamide treatment, serum Nrg4 levels dropped markedly from 3.57 ± 1.26 to 1.94 ± 0.72 ng/ml (P < 0.001). After adjustment for potential confounders, serum Nrg4 levels were independently associated with hyperthyroidism. The upregulation of Nrg4 expression in the livers and white adipose tissues by T3 was further confirmed by animal and cell culture experiments.
Conclusions
Serum Nrg4 levels were increased in patients with hyperthyroidism. The liver and white adipose tissue might be primary sources contributing to elevated serum Nrg4 concentrations.
Peter Wolf
Peter Wolf
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
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Yvonne Winhofer
Yvonne Winhofer
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
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Martin Krššák
Martin Krššák
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria
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High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria
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Michael Krebs
Michael Krebs
Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
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in various endocrine diseases also impact the cardiac morphology and function. We and others have demonstrated the importance of a well-balanced hormonal and metabolic homeostasis to maintain myocardial energy metabolism so that heart function can
Kaisa K Ivaska
Kaisa K Ivaska
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Maikki K Heliövaara
Maikki K Heliövaara
Department of Cell Biology and Anatomy, Department of Medicine, Turku PET Centre, Department of Radiology, Medical Imaging Centre of Southwest Finland, Department of Endocrinology, Abdominal Center: Endocrinology, Minerva Foundation Institute for Medical Research, Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland
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Pertti Ebeling
Pertti Ebeling
Department of Cell Biology and Anatomy, Department of Medicine, Turku PET Centre, Department of Radiology, Medical Imaging Centre of Southwest Finland, Department of Endocrinology, Abdominal Center: Endocrinology, Minerva Foundation Institute for Medical Research, Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland
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Marco Bucci
Marco Bucci
Department of Cell Biology and Anatomy, Department of Medicine, Turku PET Centre, Department of Radiology, Medical Imaging Centre of Southwest Finland, Department of Endocrinology, Abdominal Center: Endocrinology, Minerva Foundation Institute for Medical Research, Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland
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Ville Huovinen
Ville Huovinen
Department of Cell Biology and Anatomy, Department of Medicine, Turku PET Centre, Department of Radiology, Medical Imaging Centre of Southwest Finland, Department of Endocrinology, Abdominal Center: Endocrinology, Minerva Foundation Institute for Medical Research, Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland
Department of Cell Biology and Anatomy, Department of Medicine, Turku PET Centre, Department of Radiology, Medical Imaging Centre of Southwest Finland, Department of Endocrinology, Abdominal Center: Endocrinology, Minerva Foundation Institute for Medical Research, Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland
Department of Cell Biology and Anatomy, Department of Medicine, Turku PET Centre, Department of Radiology, Medical Imaging Centre of Southwest Finland, Department of Endocrinology, Abdominal Center: Endocrinology, Minerva Foundation Institute for Medical Research, Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland
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Department of Cell Biology and Anatomy, Department of Medicine, Turku PET Centre, Department of Radiology, Medical Imaging Centre of Southwest Finland, Department of Endocrinology, Abdominal Center: Endocrinology, Minerva Foundation Institute for Medical Research, Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland
Department of Cell Biology and Anatomy, Department of Medicine, Turku PET Centre, Department of Radiology, Medical Imaging Centre of Southwest Finland, Department of Endocrinology, Abdominal Center: Endocrinology, Minerva Foundation Institute for Medical Research, Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland
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H Kalervo Väänänen
H Kalervo Väänänen
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Pirjo Nuutila
Pirjo Nuutila
Department of Cell Biology and Anatomy, Department of Medicine, Turku PET Centre, Department of Radiology, Medical Imaging Centre of Southwest Finland, Department of Endocrinology, Abdominal Center: Endocrinology, Minerva Foundation Institute for Medical Research, Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland
Department of Cell Biology and Anatomy, Department of Medicine, Turku PET Centre, Department of Radiology, Medical Imaging Centre of Southwest Finland, Department of Endocrinology, Abdominal Center: Endocrinology, Minerva Foundation Institute for Medical Research, Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland
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Department of Cell Biology and Anatomy, Department of Medicine, Turku PET Centre, Department of Radiology, Medical Imaging Centre of Southwest Finland, Department of Endocrinology, Abdominal Center: Endocrinology, Minerva Foundation Institute for Medical Research, Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland
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Heikki A Koistinen
Heikki A Koistinen
Department of Cell Biology and Anatomy, Department of Medicine, Turku PET Centre, Department of Radiology, Medical Imaging Centre of Southwest Finland, Department of Endocrinology, Abdominal Center: Endocrinology, Minerva Foundation Institute for Medical Research, Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland
Department of Cell Biology and Anatomy, Department of Medicine, Turku PET Centre, Department of Radiology, Medical Imaging Centre of Southwest Finland, Department of Endocrinology, Abdominal Center: Endocrinology, Minerva Foundation Institute for Medical Research, Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland
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Department of Cell Biology and Anatomy, Department of Medicine, Turku PET Centre, Department of Radiology, Medical Imaging Centre of Southwest Finland, Department of Endocrinology, Abdominal Center: Endocrinology, Minerva Foundation Institute for Medical Research, Institute of Biomedicine, University of Turku, FI-20520 Turku, Finland
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Introduction Bone is increasingly recognized as an effector in energy metabolism via its interactions with other tissues (1, 2) . The role of bone-derived osteocalcin (OC) as a novel endocrine regulator of glucose and lipid metabolism was
Yiqiong Ma
Yiqiong Ma
Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China
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Zhaowei Chen
Zhaowei Chen
Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China
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Yu Tao
Yu Tao
Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China
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Jili Zhu
Jili Zhu
Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China
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Hongxia Yang
Hongxia Yang
Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China
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Wei Liang
Wei Liang
Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China
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Guohua Ding
Guohua Ding
Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China
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as the mitochondrial biosynthesis factor PGC1α (peroxisome proliferators activated receptor gamma co-activator-1α) ( 20 ). These results indicate metabolic abnormalities in the mitochondria. To meet the energy metabolism requirements of tissues and
Davoud Jafari-Gharabaghlou
Davoud Jafari-Gharabaghlou
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Mostafa Vaghari-Tabari
Mostafa Vaghari-Tabari
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Hajar Oghbaei
Hajar Oghbaei
Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran
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Laura Lotz
Laura Lotz
Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany
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Reza Zarezadeh
Reza Zarezadeh
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Yeganeh Rastgar Rezaei
Yeganeh Rastgar Rezaei
Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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Mahnaz Ranjkesh
Mahnaz Ranjkesh
Medical Radiation Science Research Group (MRSRG), Tabriz University of Medical Sciences, Tabriz, Iran
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Mohammad Nouri
Mohammad Nouri
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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Amir Fattahi
Amir Fattahi
Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
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Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
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Saba Nikanfar
Saba Nikanfar
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
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Ralf Dittrich
Ralf Dittrich
Department of Obstetrics and Gynecology, Erlangen University Hospital, Friedrich-Alexander University of Erlangen–Nürnberg, Erlangen, Germany
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-like factors called adipokines. Adipokines are a kind of cytokine that contributes to energy metabolism, inflammation, immunity, and angiogenesis, as well as, reproductive maturity and fertility ( 6 , 7 , 8 , 9 ). Regarding the latter effect, it has been
Dmitry M Davydov
Dmitry M Davydov
Laboratory of Neuroimmunopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia
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Malik K Nurbekov
Malik K Nurbekov
Laboratory of Sociogenomics, Moscow State Pedagogical University, Moscow, Russia
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status in individuals with and without type 2 diabetes (e.g., altered erythrocyte physiology), individual variance in both glycemic parameters can reflect different aspects of energy metabolism that are modulated by different gene polymorphisms. However
Xianghe Chen
Xianghe Chen
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Xinyu Zeng
Xinyu Zeng
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Xiao Qiu
Xiao Qiu
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Chi Liu
Chi Liu
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Pengcheng Lu
Pengcheng Lu
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Ziming Shen
Ziming Shen
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Xiangxiang Zhou
Xiangxiang Zhou
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China
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Kang Yang
Kang Yang
Department of Rehabilitation Medicine, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China
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’s pathological progression to death. Meanwhile, its fibrosis degree affects renal function ( 1 , 2 ). Silent information regulator factor 2-related enzyme 1 (Sirt1), as a key factor in regulating energy metabolism, exerts a nephroprotective effect by mediating
Chao Xu
Chao Xu
Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China
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Xiang-Fei Li
Xiang-Fei Li
Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China
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Hong-Yan Tian
Hong-Yan Tian
Department of Ocean Technology, College of Marine and Biology Engineering, Yancheng Institute of Technology, Yancheng, Province Jiangsu, China
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Hua-Juan Shi
Hua-Juan Shi
Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China
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Ding-Dong Zhang
Ding-Dong Zhang
Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China
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Kenneth Prudence Abasubong
Kenneth Prudence Abasubong
Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China
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Wen-Bin Liu
Wen-Bin Liu
Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China
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( 2 ). However, to date, the energy metabolism of fish after a GTT has barely been investigated. It is now widely acknowledged that, the energy metabolism of fish is monitored by the intracellular energy sensors ( 1 , 10 ). Indeed, several studies
Mohammed S Albreiki
Mohammed S Albreiki
Department of Biochemistry and Physiology, Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK
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Benita Middleton
Benita Middleton
Department of Biochemistry and Physiology, Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK
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Shelagh M Hampton
Shelagh M Hampton
Department of Biochemistry and Physiology, Centre for Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK
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NR. Detrimental effects of constant light exposure and high-fat diet on circadian energy metabolism and insulin sensitivity . Journal of the Federation of American Societies for Experimental Biology 2013 27 1721 – 1732 . ( doi:10.1096/fj.12
Riying Liang
Riying Liang
Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
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Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
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Meijun Wang
Meijun Wang
Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
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Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
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Chang Fu
Chang Fu
Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
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Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
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Hua Liang
Hua Liang
Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
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Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
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Hongrong Deng
Hongrong Deng
Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
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Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
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Ying Tan
Ying Tan
Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
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Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
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Fen Xu
Fen Xu
Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
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Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
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Mengyin Cai
Mengyin Cai
Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
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Guangdong Provincial Key Laboratory of Diabetology, Guangzhou, China
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play a vital role in maintaining the balance of blood glucose, blood lipid, and energy metabolism ( 14 ). The protective effects of SIRT1, such as regulation of energy metabolism, anti-fibrosis, and anti-oxidative stress, have been detected in various
