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Laura Potasso Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland

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Julie Refardt Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland

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Irina Chifu Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Wuerzburg Germany

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Martin Fassnacht Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Wuerzburg, Wuerzburg Germany
Central Laboratory, University Hospital Wuerzburg, Wuerzburg, Germany

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Wiebke Kristin Fenske Integrated Research and Treatment Center for Adiposity Diseases, Leipzig University Medical Center, Leipzig, Germany
Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany

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Mirjam Christ-Crain Department of Endocrinology, Diabetology and Metabolism, University Hospital Basel, Basel, Switzerland
Department of Clinical Research, University of Basel, Basel, Switzerland

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-Oliveira A Drescher T Bilz S Vogt DR A copeptin-based approach in the diagnosis of diabetes insipidus . New England Journal of Medicine 2018 379 428 – 439 . ( https://doi.org/10.1056/NEJMoa1803760 ) 2 Rizoli SB Rhind SG Shek PN Inaba

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Amit Kumar Department of Medicine, Christian Medical College and Hospital, Ludhiana, Punjab, India

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Maria Ghosh Department of Biochemistry, Christian Medical College and Hospital, Ludhiana, Punjab, India

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Jubbin Jagan Jacob Department of Endocrinology, Christian Medical College and Hospital, Ludhiana, Punjab, India

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hyponatremia have osmotically inappropriate anti-diuretic hormone (ADH) secretion ( 6 ). This makes the use of direct measurements of ADH or co-secreted proteins like co-peptin or other indirect markers like urine osmolality and solute-free water clearance not

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Liang Xue Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China
Department of Neurosurgery, 900TH Hospital of the Joint Logistics Support Force, Fuzhou, Fujian, China

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Jianwu Wu Department of Neurosurgery, 900TH Hospital of the Joint Logistics Support Force, Fuzhou, Fujian, China

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Jie Chen Department of Radiology, 900TH Hospital of the Joint Logistics Support Force, Fuzhou, Fujian, China

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Yongkai Yang Department of Neurosurgery, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, Fujian, China

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://doi.org/10.3171/2013.11.JNS131320 ) 19 Morgenthaler NG Struck J Jochberger S Dünser MW . Copeptin: clinical use of a new biomarker . Trends in Endocrinology and Metabolism 2008 19 43 – 49 . ( https://doi.org/10.1016/j.tem.2007.11.001 ) 20

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Jens P Goetze
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Linda M Hilsted
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Jens F Rehfeld
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Urban Alehagen Department of Clinical Biochemistry, Division of Cardiovascular Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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.03.031 ). 15 Alehagen U Dahlström U Rehfeld JF Goetze JP . Association of copeptin and N-terminal proBNP concentrations with risk of cardiovascular death in older patients with symptoms of heart failure . Journal of the American Medical Association

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Anna Sjöström Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden

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Susanne Rysz Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden
Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden

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Henrik Sjöström Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Center for Neurology, Academic Specialist Center, Stockholm, Sweden

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Charlotte Höybye Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden

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, AVP, copeptin, urinary sodium, potassium, and osmolality, together with clinical information of fluid and sodium input and output, would be of great value. Supplementary materials This is linked to the online version of the paper at https

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Sun Fei Wuxi Medical College of Jiangnan University, Wuxi, China

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Min Liu Wuxi Maternity and Child Health Care Hospital, Wuxi, China

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Hu Shanshan Wuxi Maternity and Child Health Care Hospital, Wuxi, China

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Ruijie Xie Department of Microsurgery, University of South China, Hengyang, China

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Wu Danni Wuxi Medical College of Jiangnan University, Wuxi, China

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Zhou Ningying Wuxi Medical College of Jiangnan University, Wuxi, China

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, et al. Central noradrenaline transporter availability is linked with HPA axis responsiveness and copeptin in human obesity and non-obese controls . Stress 2019 22 93 – 102 . ( https://doi.org/10.1080/10253890.2018.1511698 ) 48 Slavich GM

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Nishchil Patel Department of Endocrinology, University Hospital Plymouth, UK

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Kagabo Hirwa Department of Endocrinology, University Hospital Plymouth, UK

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Gemma Gardner Department of Endocrinology, University Hospital Plymouth, UK

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Kirsten Pearce Department of Endocrinology, University Hospital Plymouth, UK

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Jinny Jeffery Department of Endocrinology, University Hospital Plymouth, UK

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Fizzah Iqbal Department of Endocrinology, University Hospital Plymouth, UK

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Daniel Flanagan Department of Endocrinology, University Hospital Plymouth, UK

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at presentation with inappropriately normal gonadotrophins. Total testosterone concentrations were 5.1 and 6.2 nmol/L. They did not start testosterone replacement. There were no cases where AVP deficiency was suspected. Copeptin was not measured. In

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