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Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, UK
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. A causative effect of irradiation to impair posterior pituitary function is yet to be shown. The prevalence of pituitary hormone deficits in a large single-centre cohort of childhood cancer survivors followed for a median of 24 years and in whom the
Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
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Department of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Aarhus, Denmark
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark
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Tryggvadottir L Wesenberg F Hasle H Long-term inpatient disease burden in the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) study: a cohort study of 21,297 childhood cancer survivors . PLoS Medicine 2017 14 e1002296. ( https://doi.org/10
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Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands
Endo-ERN European Reference Network on Rare endocrine conditions
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Endo-ERN European Reference Network on Rare endocrine conditions
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Division of Endocrinology and Metabolism, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
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problems: a report from the Childhood Cancer Survivor Study . Psychooncology 2018 27 2754 – 2760 . ( https://doi.org/10.1002/pon.4881 ) 29 Zeltzer LK Recklitis C Buchbinder D Zebrack B Casillas J Tsao JC Lu Q & Krull K . Psychological
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Department of Exercise Physiology, Child Development & Exercise Center, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Department of Radiology, Wilhelmina Children’s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
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Division of Pediatric Oncology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands
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of childhood brain tumors . Cancer 2010 116 3034 – 3044 . ( https://doi.org/10.1002/cncr.25051 ) 8 Zhang FF Saltzman E Must A Parsons SK . Do childhood cancer survivors meet the diet and physical activity guidelines? A review of guidelines
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-quality evidence supporting this is lacking ( 10 ). According to a recent guideline for surveillance of HP deficiencies (HPDs) in childhood cancer survivors, the diagnosis of central hypothyroidism is more likely when FT4 concentrations are progressively declining
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of these markers may be questioned in this subgroup of patients, lending support to Green et al. , who reported a poor specificity of FSH and inhibin B in determining spermatogenic capacity in adult male childhood cancer survivors ( 27 ). Therefore
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Edinburgh Royal Hospital for Sick Children, Edinburgh, UK
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relation to infertility, has been shown to be between 7.5 and 10 g/m 2 ( 48 , 49 , 50 ). However, a recent large study of non-irradiated childhood cancer survivors failed to identify any threshold dose for alkylating agent exposure that predicted
Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
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John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
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RT Anderson RA & Wallace WHB . Follicle stimulating hormone is an accurate predictor of azoospermia in childhood cancer survivors . PLoS One 2017 12 e0181377 . ( https://doi.org/10.1371/journal.pone.0181377 ) 23 Action Duchene . Mitch Coles
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idiopathic and isolated, without other pituitary hormone deficiencies. Other less common causes of CO-GHD include congenital, structural, and acquired causes ( 4 , 5 , 7 ) ( Table 1 ). Importantly, childhood cancer survivors especially those who had