Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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Centre for Paediatrics and Child Health, Faculty of Medicine, Centre for Genetic Medicine, 5th Floor Research, Genetic Medicine, Institute of Human Development, Faculty of Medical and Human Sciences, University of Manchester, UK
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(23) and increased in desmoid tumour fibroblasts (27) and brain tumours (medulloblastomas and meningiomas) (28, 29) . Several other genes in the top 10 upregulated probesets are also overexpressed in tumours including PCP4 in leiomyomas (22
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p53 null mice (p53 -/- ) which develop multiple tumours similar to those in patients with the Li-Fraumeni syndrome (e.g. soft tissue sarcomas, osteosarcomas, breast cancer, brain tumours, leukaemia and adrenocortical carcinomas), bred on CE/J and 129
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, accounting for approximately 20% of cases. It may result from brain tumours following radiotherapy affecting the central nervous system. IGF-I and IGFBP-3 in non-GH deficient short stature IGF-I SDS and IGFBP-3 SDS below −2 would indicate an