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Wei Li Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China

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Qing Huang Collage of Tourism and Service Management, Nankai University, Tianjin, People’s Republic of China

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Danyang Sun Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China

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Guizhi Zhang Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China

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Jian Tan Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China

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conducted in thyroid cancer cell lines. Lentivirus-mediated small interfering RNA (siRNA) targeting of RDM1 was used to downregulate gene expression. Then, experiments were performed to examine the effect of RDM1 silencing on the cell cycle, apoptosis

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Jiwen Yang Department of Nuclear Medicine, Yijishan Hospital of Wannan Medical College, Wuhu City, Anhui Province, China

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Yayin Huang Department of Clinical Laboratory, The Second People’s Hospital of Wuhu, Wuhu City, Anhui Province, China

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Bohan Dong Department of Biochemistry and Molecular Biology, Wannan Medical College, Wuhu City, Anhui Province, China

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Yunhai Dai Department of Nuclear Medicine, Yijishan Hospital of Wannan Medical College, Wuhu City, Anhui Province, China

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Highlights lncRNA DLEU2 is significantly upregulated in thyroid cancer tissues and cell lines. DLEU2 accelerates the proliferation, migration and aerobic glycolysis while inhibits the apoptosis of thyroid cancer cells. miR-205

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Emily Warmington Institute of Metabolism and System Research, University of Birmingham, Birmingham, UK

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Gabrielle Smith Institute of Metabolism and System Research, University of Birmingham, Birmingham, UK

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Vasileios Chortis Institute of Metabolism and System Research, University of Birmingham, Birmingham, UK

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Raimunde Liang Division of Endocrinology and Diabetes, University Hospital of Wuerzburg, Wuerzburg, Germany
Department of Neurosurgery, Technical University Munich (TMU), Munich, Germany

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Juliane Lippert Division of Endocrinology and Diabetes, University Hospital of Wuerzburg, Wuerzburg, Germany

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Sonja Steinhauer Division of Endocrinology and Diabetes, University Hospital of Wuerzburg, Wuerzburg, Germany

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Laura-Sophie Landwehr Division of Endocrinology and Diabetes, University Hospital of Wuerzburg, Wuerzburg, Germany

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Constanze Hantel Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland
Medizinische Klinik Und Poliklinik III, University Hospital Carl Gustav Carus, Dresden, Germany

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Katja Kiseljak-Vassiliades Division of Endocrinology Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

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Margaret E Wierman Division of Endocrinology Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA

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Barbara Altieri Division of Endocrinology and Diabetes, University Hospital of Wuerzburg, Wuerzburg, Germany

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Paul A Foster Institute of Metabolism and System Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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Cristina L Ronchi Institute of Metabolism and System Research, University of Birmingham, Birmingham, UK
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK

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shown to be frequently overexpressed ( 9 , 16 , 17 ) and associated with shorter patient survival ( 16 , 17 ). Moreover, the first-generation inhibitor BI-2536 has been demonstrated to reduce cell viability and induce apoptosis in standard ACC cell

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Joanna Klubo-Gwiezdzinska National Institute of Health, NIDDK, Office 10 Center Drive, Bethesda, Maryland, USA
Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA

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John Costello Jr Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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Kirk Jensen Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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Aneeta Patel Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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Rok Tkavc Department of Pathology, Uniformed Services University of the Health Sciences, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA

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Douglas Van Nostrand Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA

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Kenneth D Burman Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA

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Leonard Wartofsky Division of Endocrinology, Department of Medicine, Medstar Washington Hospital Center, Washington Hospital Center, Northwest, Washington, District of Columbia, USA

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Vasyl Vasko Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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radioprotective activity in normal cells, amifostine may enhance radiation-inducible apoptosis in cancer cells harboring oncogene mutations. It has to be noted that, despite the clinical use of amifostine in treatment of thyroid cancer patients, there is no

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M L Gild Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia

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M Bullock Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia

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C K Pon Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia

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B G Robinson Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia

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R J Clifton-Bligh Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia
Cancer Genetics Laboratory, Department of Endocrinology, Kolling Institute of Medical Research, Sydney, New South Wales, Australia

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it is this mechanism that is exploited when targeting its inhibition (5) . HSP90 client proteins include many kinases involved in apoptosis and signaling. These include AKT (and its phosphorylated form), p53, Raf-1, Bcr-abl, and BRAF; many of these

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Caio Jordão Teixeira Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Junia Carolina Santos-Silva Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Dailson Nogueira de Souza Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Alex Rafacho Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil

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Gabriel Forato Anhe Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil

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Silvana Bordin Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil

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pregnant rats show evident plasticity, which allows the morphological structures to return to the nonpregnant state just after delivery. Increased apoptosis and reduced proliferation account for the reversal of pancreatic β-cell mass as early as 3–4 days

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Robert I Menzies The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Xin Zhao The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Linda J Mullins The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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John J Mullins The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Carolynn Cairns The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Nicola Wrobel The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Donald R Dunbar The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Matthew A Bailey The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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Christopher J Kenyon The University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh, UK

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proliferation and apoptosis that increases cell number. Sterol/lipid metabolic pathways are also changed in several ways to allow cholesterol to be channelled towards steroidogenesis. Materials and methods All experiments involving animals were approved

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Shikai Gui Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China

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Wanli Yu Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China

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Jiabao Xie Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China

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Lunshan Peng Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China

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Yuanyuan Xiong Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China

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Zhen Song Nanchang University, Nanchang, Jiangxi Province, China
Department of Urology, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China

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Haitao Luo Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China

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Juexian Xiao Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China

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Shengtao Yuan Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu Province, China

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Zujue Cheng Department of Neurosurgery, the 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China
Nanchang University, Nanchang, Jiangxi Province, China
Institute of Neuroscience, Nanchang University, Nanchang, Jiangxi Province, China

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were then fixed with 4% paraformaldehyde and stained with 2% crystal violet. Colonies comprising 50 or more cells were counted under a microscope. Apoptosis assay Cell apoptosis was detected using the Apoptosis Detection Kit (KeyGEN BioTECH

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Fan Zhang Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China

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Jian Chen Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China

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Xinyue Lin Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China

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Shiqiao Peng Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China

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Xiaohui Yu Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China

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Zhongyan Shan Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China

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Weiping Teng Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China

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relationship between cognitive impairment due to SCH and the apoptosis in cerebral cortex remains unclear. The p75 neurotrophin receptor (p75 NTR ) is an important member of the death receptor family. Although the role of the p75 NTR -mediated signal

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Qian Deng Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Yue Zhu Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Mengmeng Zhang Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Aihua Fei Department of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China

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Jiaqi Liang Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Jinjin Zheng Graduate College of Anhui University of Chinese Medicine, Hefei, China

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Qingping Zhang College of Acupuncture-moxibustion and Tuina, Anhui University of Chinese Medicine, Hefei, China

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Tong Cheng Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, China

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Xia Ge Department of Endocrinology, The Second Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China

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decreases. Distinct from the features of necrosis, autophagy, and apoptosis, ferroptosis could result in compromised plasma membrane integrity, mild chromatin condensation, cytoplasm and cytoplasmic organelles swelling, increased mitochondrial membrane

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