Xiaowen Zhang
Xiaowen Zhang
Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
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Chen Han
Chen Han
Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
Department of Endocrinology and Metabolism, Drum Tower Clinical Medical College, Southeast University, Nanjing, China
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Department of Endocrinology and Metabolism, Drum Tower Clinical Medical College, Southeast University, Nanjing, China
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Hongwei Wang
Hongwei Wang
State Key Laboratory of Analytical Chemistry for Life Science & Jiangsu Key Laboratory of Molecular Medicine, Nanjing University School of Medicine, Nanjing, China
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Xinghong Sun
Xinghong Sun
Department of Ophthalmology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China
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Xin Dou
Xin Dou
Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China
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Xueying He
Xueying He
Department of Radiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China
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Di Wu
Di Wu
Department of Radiology, Southeast University Medical School Affiliated Zhongda Hospital, Nanjing, China
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Shanmei Shen
Shanmei Shen
Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
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Dalong Zhu
Dalong Zhu
Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
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Xinlin Zhang
Xinlin Zhang
Department of Cardiology, Nanjing University Medical School Affiliated Drum Tower Hospital, Nanjing, China
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Yan Bi
Yan Bi
Department of Endocrinology, Drum Tower Hospital affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases, Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital affiliated to Nanjing University Medical School, Nanjing, China
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indicator of systemic inflammation. NLR has been reported to be associated with clinical prognosis in multiple disease contexts, including thyroid diseases ( 8 , 9 ). NLR predicts relapse in GD patients following antithyroid drug therapy ( 10 ) and disease
Danzhou Fang
Danzhou Fang
Department of Nuclear Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Shiying Li
Shiying Li
Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Changgu Zhou
Changgu Zhou
Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Yirui Wang
Yirui Wang
Department of Nuclear Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Gengbiao Yuan
Gengbiao Yuan
Department of Nuclear Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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HuiHui Zhang
HuiHui Zhang
Department of Nuclear Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Maohua Rao
Maohua Rao
Department of Nuclear Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
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. Contemporary hyperthyroidism treatments encompass thyroidectomy, antithyroid drugs, and radioactive iodine ( 131 I) therapy ( 7 ). However, for those with hyperthyroidism and concomitant liver failure, surgery may not be feasible due to the requirement of near
Yuegui Wang
Yuegui Wang
Department of Ultrasound, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China
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Liwei Hong
Liwei Hong
Department of Nuclear Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China
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Caiyun Yang
Caiyun Yang
Department of Ultrasound, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China
School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, China
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School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, China
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Guorong Lv
Guorong Lv
School of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, China
Quanzhou Medical College, Quanzhou, Fujian, China
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Quanzhou Medical College, Quanzhou, Fujian, China
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Kangjian Wang
Kangjian Wang
Department of Ultrasound, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China
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Xuepeng Huang
Xuepeng Huang
Department of Nuclear Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China
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Haolin Shen
Haolin Shen
Department of Ultrasound, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China
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orbitopathy ( 5 ). Therapies for GD include antithyroid drugs (ATDs), thyroidectomy, or radioactive iodine (RAI) therapy. ATD has only a 50% success rate for most patients after 1 year of treatment, and it may cause side effects such as agranulocytosis
Lian Duan
Lian Duan
Department of Nuclear Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China
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Han-Yu Zhang
Han-Yu Zhang
Changzhi Medical College, Changzhi, Shanxi, China
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Min Lv
Min Lv
Department of Nuclear Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China
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Han Zhang
Han Zhang
Changzhi Medical College, Changzhi, Shanxi, China
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Yao Chen
Yao Chen
Changzhi Medical College, Changzhi, Shanxi, China
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Ting Wang
Ting Wang
Department of Nuclear Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China
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Yan Li
Yan Li
Department of Nuclear Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China
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Yan Wu
Yan Wu
Department of Clinical Laboratory, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China
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Junfeng Li
Junfeng Li
Department of Radiology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China
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Kefeng Li
Kefeng Li
School of Medicine, University of California, San Diego, California, USA
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per 100,000 individuals per year ( 3 , 4 ). Current treatment for GD patients includes antithyroid drugs (ATDs), radioiodine therapy ( 131 I therapy) (RAI), and thyroidectomy ( 5 ). ATDs tend to have a higher failure rate. In addition, approximately
Ruth Percik
Ruth Percik
Institute of Endocrinology, Diabetes and Metabolism, Sheba Medical Centre, Ramat Gan, Israel
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Sherwin Criseno
Sherwin Criseno
Department of Endocrinology, University Hospital Birmingham, Birmingham, UK
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Safwaan Adam
Safwaan Adam
Department of Endocrinology, The Christie NHS Foundation Trust, Manchester, UK
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Kate Young
Kate Young
Royal Marsden Hospital, London, UK
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Daniel L Morganstein
Daniel L Morganstein
Department of Endocrinology, Chelsea and Westminster Hospital, London, UK
Royal Marsden Hospital, London, UK
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Royal Marsden Hospital, London, UK
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reports of Graves’ disease resulting in persistent thyrotoxicosis requiring antithyroid drugs such as carbimazole ( 44 , 45 , 46 , 47 , 48 ). Graves’ disease should be considered if thyrotoxicosis persists for more than 4 weeks and in those who present
Xiaoya Zheng
Xiaoya Zheng
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Shanshan Yu
Shanshan Yu
Pathology Department, Chongqing Medical University, Chongqing, China
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Jian Long
Jian Long
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Qiang Wei
Qiang Wei
Prevention of Disease Department, Chongqing Jiulongpo District Hospital of Traditional Chinese Medicine, Chongqing, China
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Liping Liu
Liping Liu
Department of Ultrasound, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Chun Liu
Chun Liu
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Wei Ren
Wei Ren
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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lymphoma occurred at the time of the first diagnosis ( 16 ). The diagnosis of hyperthyroidism was defined as either having a decreased TSH value <0.56 µIU/mL or being treated with antithyroid drugs. The presence of hypothyroidism was defined as either
Xingyao Tang
Xingyao Tang
Beijing Tongren Hospital, Capital Medical University
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Zhi-Hui Song
Zhi-Hui Song
Department of Pharmacy, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Dawei Wang
Dawei Wang
General Practice Department, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Jinkui Yang
Jinkui Yang
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Marly Augusto Cardoso
Marly Augusto Cardoso
Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil
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Jian-Bo Zhou
Jian-Bo Zhou
Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
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Rafael Simó
Rafael Simó
Endocrinology and Nutrition Department, Hospital Universitari Vall d’Hebron, Diabetes and Metabolism Research Unit, Vall d’Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
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Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain
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study, the lack of data on treatment and the effects of treatment on thyroid dysfunction limited a more rigorous analysis. Some reports declared the impacts of antithyroid drugs on dementia ( 39 ). The influence of antithyroid drugs on dementia needs
Qian Yang
Qian Yang
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Wencai Ke
Wencai Ke
Department of Clinical Laboratory Medicine, Fifth People's Hospital of Shanghai Fudan University, Shanghai, China
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Fanfan Pan
Fanfan Pan
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Xinmei Huang
Xinmei Huang
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Jun Liu
Jun Liu
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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Bingbing Zha
Bingbing Zha
Department of Endocrinology, Fifth People’s Hospital of Shanghai Fudan University, Shanghai, China
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step in thyroid hormone synthesis. Methimazole (MMI) is an established first-line therapy for GD in China and MMI-induced granulocytosis is dose-dependent ( 4 ). Antithyroid drug (ATD)-associated agranulocytosis is a rare but life-threatening event
Waleed K W Al-Badri
Waleed K W Al-Badri
Orbital center Amsterdam, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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Hinke Marijke Jellema
Hinke Marijke Jellema
Orbital center Amsterdam, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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Arnaud R G G Potvin
Arnaud R G G Potvin
Orbital center Amsterdam, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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Ruth M A van Nispen
Ruth M A van Nispen
Amsterdam University Medical Center, Vrije Universiteit, Department of Ophthalmology, Amsterdam Public Health research institute, Amsterdam, the Netherlands
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Peter H Bisschop
Peter H Bisschop
Department of Endocrinology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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Peerooz Saeed
Peerooz Saeed
Orbital center Amsterdam, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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. ( https://doi.org/10.4103/1119-3077.100620 ) 44 Fukao A Takamatsu J Kubota S Miyauchi A & Hanafusa T . The thyroid function of Graves’ disease patients is aggravated by depressive personality during antithyroid drug treatment
Jia Liu
Jia Liu
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Min Liu
Min Liu
Department of Radiology, China-Japan Friendship Hospital, Beijing, China
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Zhe Chen
Zhe Chen
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Yumei Jia
Yumei Jia
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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Guang Wang
Guang Wang
Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
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heterogeneous thyroid in a thyroid ultrasound ( 12 ). Individuals with systemic inflammatory disease, cancer, claustrophobia and metal implants were excluded. No subject had been administered levothyroxine or antithyroid drugs. Individuals who were pregnant
