Lianghui You
Lianghui You
Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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Yan Wang
Yan Wang
Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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Yao Gao
Yao Gao
Department of Endocrinology, Children’s Hospital of Nanjing Medical University, Nanjing, China
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Xingyun Wang
Xingyun Wang
Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
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Xianwei Cui
Xianwei Cui
Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
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Yanyan Zhang
Yanyan Zhang
Beijing Chaoyang Distirct Maternal and Child Health Care Hospital, Beijing, China
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Lingxia Pang
Lingxia Pang
Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
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Chenbo Ji
Chenbo Ji
Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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Xirong Guo
Xirong Guo
Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Xia Chi
Xia Chi
Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China
Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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Institute of Pediatrics, Nanjing Medical University, Nanjing, China
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adipocyte differentiation and cold-mediated thermogenic activation. Other types of cold-regulated adipokines such as FGF21 ( 18 ) and apelin ( 19 ) have been also demonstrated to regulate Ucp1 expression and adaptive thermogenesis. Identification of
Yu Lin
Yu Lin
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Yingying Zhang
Yingying Zhang
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Lei Xu
Lei Xu
Maternal and Child Health Care Hospital of Dongchangfu District, Liaocheng, People’s Republic of China
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Wei Long
Wei Long
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Chunjian Shan
Chunjian Shan
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Hongjuan Ding
Hongjuan Ding
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Lianghui You
Lianghui You
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Chun Zhao
Chun Zhao
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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Zhonghua Shi
Zhonghua Shi
State Key Laboratory of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, People’s Republic of China
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which preadipocytes develop into mature adipocytes, is a critical process for fat mass accumulation and obesity development. Although fetal hyperinsulinemia caused by maternal hyperglycemia has been considered as an important cause of GDM macrosomia, the
Emmely M de Vries
Emmely M de Vries
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
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Hermina C van Beeren
Hermina C van Beeren
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
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Albert C W A van Wijk
Albert C W A van Wijk
Department of Experimental Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
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Andries Kalsbeek
Andries Kalsbeek
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
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Hypothalamic Integration Mechanisms, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
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Johannes A Romijn
Johannes A Romijn
Department of Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
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Eric Fliers
Eric Fliers
Department of Endocrinology and Metabolism, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
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Anita Boelen
Anita Boelen
Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology & Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
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another important metabolic organ responsive to TH. TH counterintuitively stimulates both fatty acid synthesis and oxidation in WAT ( 11 ) and is also important for adipocyte differentiation ( 12 ). In addition, T 3 stimulates UCP2 expression in WAT
Huguette S Brink
Huguette S Brink
Department of Endocrinology, Maasstad Hospital, Rotterdam, The Netherlands
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Aart Jan van der Lely
Aart Jan van der Lely
Department of Endocrinology, Erasmus University MC, Rotterdam, The Netherlands
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Joke van der Linden
Joke van der Linden
Department of Endocrinology, Maasstad Hospital, Rotterdam, The Netherlands
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developing GD ( 25 ). The global increase in GD is largely attributed to the ongoing obesity pandemic ( 26 ). Obesity is characterized by altered production of proinflammatory cytokines by adipocytes causing a state of chronic low-grade inflammation ( 27
Huiyuan Zhai
Huiyuan Zhai
Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China
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Dongxu Wang
Dongxu Wang
Department of Geriatrics, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China
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Yong Wang
Yong Wang
Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China
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Hongwei Gu
Hongwei Gu
Central Laboratory, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China
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Juan Jv
Juan Jv
Department of Cardiology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China
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Liangliang Yuan
Liangliang Yuan
Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China
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Chao Wang
Chao Wang
Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China
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Leiyao Chen
Leiyao Chen
Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China
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classified into two main phenotypes: classical M1 macrophages and alternatively activated macrophages M2. Although both M1 and M2 macrophages increase in adipose tissue during expansion, M1 macrophages tend to dominate, aggregating around apoptotic adipocytes
Yi Jia
Yi Jia
School of Health and Exercise, The Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai, China
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Yanan Yang
Yanan Yang
School of Health and Exercise, The Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai, China
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Jing Qu
Jing Qu
School of Health and Exercise, The Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai, China
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Lijun Yin
Lijun Yin
School of Health and Exercise, The Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai, China
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Xiaohui Wang
Xiaohui Wang
School of Health and Exercise, The Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai, China
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= 4 mice/group. * P < 0.05, ** P < 0.01 vs WT. WT, wild-type mice; WT + EX, WT + exercise; chemerin (−/−), chemerin knockout mice; chemerin (−/−) + EX, chemerin (−/−) + exercise. Chemerin knockout lowered the adipocyte size of
Chan Sub Park
Chan Sub Park
Department of Breast and Thyroid Surgery, Kyungpook National University Chilgok Hospital, Buk-gu, Daegu, Republic of Korea
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Jihye Choi
Jihye Choi
Department of General Surgery, National Medical Center, Jung-gu, Seoul, Republic of Korea
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Min-Ki Seong
Min-Ki Seong
Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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Sung-Eun Hong
Sung-Eun Hong
Radiation Medicine Clinical Research Division, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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Jae-Sung Kim
Jae-Sung Kim
Radiation Medicine Clinical Research Division, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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In-Chul Park
In-Chul Park
Division of Fusion Radiology Research, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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Hyesil Seol
Hyesil Seol
Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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Woo Chul Noh
Woo Chul Noh
Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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Hyun-Ah Kim
Hyun-Ah Kim
Department of Surgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Nowon-gu, Seoul, Republic of Korea
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Introduction Estradiol is a key factor for tumorigenesis and prognosis of hormone receptor (HR)-positive breast cancer. Although estradiol is produced mainly by the ovary in premenopausal women, the adrenal gland and adipocytes are also
Juan Carlos Juárez-Cruz
Juan Carlos Juárez-Cruz
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Miriam Daniela Zuñiga-Eulogio
Miriam Daniela Zuñiga-Eulogio
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Monserrat Olea-Flores
Monserrat Olea-Flores
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Eduardo Castañeda-Saucedo
Eduardo Castañeda-Saucedo
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Miguel Ángel Mendoza-Catalán
Miguel Ángel Mendoza-Catalán
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Carlos Ortuño-Pineda
Carlos Ortuño-Pineda
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Ma Elena Moreno-Godínez
Ma Elena Moreno-Godínez
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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Sócrates Villegas-Comonfort
Sócrates Villegas-Comonfort
Instituto de Fisiología Celular, Universidad Nacional Autónoma de Mexico, Mexico City, México
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Teresita Padilla-Benavides
Teresita Padilla-Benavides
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
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Napoleón Navarro-Tito
Napoleón Navarro-Tito
Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Guerrero, México
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weight of ~16 kDa, encoded by the LEP gene located on human chromosome 7 ( 6 ). It is synthesized and secreted mainly by adipocytes, and in a smaller proportion, by the placenta, stomach, fibroblasts, skeletal muscle, and normal or tumorigenic
Xun Gong
Xun Gong
Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China
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Lili You
Lili You
Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China
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Feng Li
Feng Li
Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China
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Qingyu Chen
Qingyu Chen
Department of Medical Examination Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China
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Chaogang Chen
Chaogang Chen
Department of Clinical Nutrition, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China
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Xiaoyun Zhang
Xiaoyun Zhang
Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China
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Xiuwei Zhang
Xiuwei Zhang
Department of Endocrinology, Dongguan People’s Hospital, Dongguan, People’s Republic of China
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Wenting Xuan
Wenting Xuan
Department of Endocrinology, Dongguan People’s Hospital, Dongguan, People’s Republic of China
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Kan Sun
Kan Sun
Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China
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Guojuan Lao
Guojuan Lao
Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China
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Chuan Wang
Chuan Wang
Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China
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Yan Li
Yan Li
Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China
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Mingtong Xu
Mingtong Xu
Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China
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Meng Ren
Meng Ren
Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China
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Li Yan
Li Yan
Department of Endocrinology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of China
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-diabetes will eventually develop full diabetes, according to an ADA expert panel ( 3 ). Adiponectin, one of the most abundant peptides secreted specifically by adipocytes, has been shown to improve insulin resistance and inflammatory status ( 4 ). Adiponectin
Angelica Amorim Amato
Angelica Amorim Amato
Department of Pharmaceutical Sciences, University of Brasilia, Brasilia, Brazil
Department of Developmental and Cell Biology, University of California, Irvine, California, USA
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Department of Developmental and Cell Biology, University of California, Irvine, California, USA
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Hailey Brit Wheeler
Hailey Brit Wheeler
Department of Developmental and Cell Biology, University of California, Irvine, California, USA
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Bruce Blumberg
Bruce Blumberg
Department of Developmental and Cell Biology, University of California, Irvine, California, USA
Department of Pharmaceutical Sciences, University of California, Irvine, California, USA
Department of Biomedical Engineering, University of California, Irvine, California, USA
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Department of Pharmaceutical Sciences, University of California, Irvine, California, USA
Department of Biomedical Engineering, University of California, Irvine, California, USA
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metabolism and lessens the risk of heart disease, hypertension, stroke, and diabetes in women ( 27 ). The number of adipocytes is determined mostly from prenatal life through adolescence ( 28 , 29 ). However, there is increasing evidence that expansion of
