Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway
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Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway
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stimulation of glucagon-like peptide 1 receptors (GLP1R). GLP1R expression/protein has been found on phaeochromocytoma cells ( 42 ) and tumours ( 43 ), but whether they function normally or if they are expressed on cells positive for anti-insulin staining is
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Faculty of Medicine, University of Latvia, Riga, Latvia
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, highlighting the role of insulin in the process. In response to increased blood glucose levels, insulin secretion is triggered by direct glucose stimulation via GLUT2 channel or indirectly via GLP-1R mediated response ( 17 ). This amplification of insulin
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, 104, 108, 109, 110) Liver cells Ectopically overexpressing PDX1 and NeuroD1 ; Down-regulating the expression of HNF1α and HNF4α ; Specific factors (GLP-1R, Notch inhibitors, TGF-β inhibitors) Conveniently accessible; Sufficient source
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-cell-specific genes, such as insulin, Glut2, Pdx-1, Nkx6.1, GLP-1R, PC-1/3, and pyruvate carboxylase ( 36 ). Studies have shown that MAFA is an important regulator of glucose-stimulated insulin secretion ( 37 ), and it can drive insulin expression by binding to the
Division of Epidemiology and Biometry, Carl von Ossietzky Universität, Oldenburg, Germany
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% reporting these measures as helpful, respectively. Additionally, 38% tried weight loss medications such as central stimulating agents, metformin, glucagon-like peptide 1 receptor (GLP1R) agonists, and topiramate, and 48% found at least one of these
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Vita-Salute San Raffaele University, Milan, Italy
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glucagon-like peptide-1 receptor (GLP1R) combined with gastrin and exendin-4 also, synergistically promoted β cell reprogramming of acinar cells ( 57 ). Duct cells Reprogramming of ductal cells into β cells is one of the most controversial issue in
CEB – Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal
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CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde & Instituto Universitário de Ciências da Saúde, Gandra, Portugal
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Diabetes Association . Diabetes Care 2015 38 1964 – 1974 . ( https://doi.org/10.2337/dc15-1419 ) 21 Doggrell SA Do glucagon-like peptide-1 receptor (GLP-1R) agonists have potential as adjuncts in the treatment of type 1 diabetes? Expert Opinion
DFBMC, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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DFBMC, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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signaling pathway. However, this persistent signaling has been subsequently reported for other GPCRs, including peptide hormone receptors, such as glucagon-like peptide 1 receptor (GLP1R) ( 167 ), pituitary adenylate cyclase activating polypeptide (PACAP