Magdaléna Fořtová
Magdaléna Fořtová
Department of Medical Chemistry and Clinical Biochemistry, Charles University, Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic
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Lenka Hanousková
Lenka Hanousková
Department of Medical Chemistry and Clinical Biochemistry, Charles University, Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic
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Martin Valkus
Martin Valkus
Department of Medical Chemistry and Clinical Biochemistry, Charles University, Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic
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Jana Čepová
Jana Čepová
Department of Medical Chemistry and Clinical Biochemistry, Charles University, Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic
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Richard Průša
Richard Průša
Department of Medical Chemistry and Clinical Biochemistry, Charles University, Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic
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Karel Kotaška
Karel Kotaška
Department of Medical Chemistry and Clinical Biochemistry, Charles University, Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic
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frequently used indicator of successful parathyroidectomy; nevertheless, the information about changes of fibroblast growth factor 23 (FGF23) levels is scarce ( 2 , 3 ). FGF23 is a phosphaturic peptide promoting phosphate excretion in urine. It is a member
Shu-Meng Hu
Shu-Meng Hu
Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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Yang-Juan Bai
Yang-Juan Bai
Department of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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Ya-Mei Li
Ya-Mei Li
Department of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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Ye Tao
Ye Tao
Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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Xian-Ding Wang
Xian-Ding Wang
Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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Tao Lin
Tao Lin
Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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Lan-Lan Wang
Lan-Lan Wang
Department of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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Yun-Ying Shi
Yun-Ying Shi
Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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closely associated with bone fracture, graft loss, cardiovascular events and all-cause death after KT ( 2 , 3 , 4 ). Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone produced by osteocytes and osteoblasts. By binding to FGF receptor 1
Anru Wang
Anru Wang
Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Department of Pediatrics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Department of Pediatrics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Xueqin Yan
Xueqin Yan
Department of Pediatrics, Boai Hospital of Zhongshan, Zhongshan, China
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Cai Zhang
Cai Zhang
Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Caiqi Du
Caiqi Du
Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Wenjun Long
Wenjun Long
Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Di Zhan
Di Zhan
Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Xiaoping Luo
Xiaoping Luo
Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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. Recent clinical and animal studies have reported that FGF19 and FGF21 are associated with obesity and T2DM ( 2 , 3 ). FGF19 and FGF21 suppress triglyceride and glucose syntheses, meanwhile inducing glycogenesis and fatty acid oxidation in the liver
Vickie Braithwaite
Vickie Braithwaite
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Kerry S Jones
Kerry S Jones
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Shima Assar
Shima Assar
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Inez Schoenmakers
Inez Schoenmakers
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Ann Prentice
Ann Prentice
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Medical Research Council (MRC) Human Nutrition Research, MRC Keneba, Elsie Widdowson Laboratories, Fulbourn Road, Cambridge CB1 9NL, UK
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Introduction Elevated plasma C-terminal fibroblast growth factor 23 (C-FGF23) concentrations have been recorded in Gambian children with putative Ca-deficiency rickets (1) and, at a lower prevalence, in apparently healthy children from the local
Carlijn A Hoekx
Carlijn A Hoekx
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Borja Martinez-Tellez
Borja Martinez-Tellez
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
Department of Nursing Physiotherapy and Medicine, SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almería, Almería, Spain
Biomedical Research Unit, Torrecárdenas University Hospital, Almería, Spain
CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
Department of Nursing Physiotherapy and Medicine, SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almería, Almería, Spain
Biomedical Research Unit, Torrecárdenas University Hospital, Almería, Spain
CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain
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Maaike E Straat
Maaike E Straat
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Magdalena M A Verkleij
Magdalena M A Verkleij
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Mirjam Kemmeren
Mirjam Kemmeren
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Sander Kooijman
Sander Kooijman
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Martin Uhrbom
Martin Uhrbom
Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca Gothenburg, Sweden
Department of Medicine, Huddinge, Karolinska Institutet Campus Flemingsberg, Neo Building, Huddinge, Sweden
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Department of Medicine, Huddinge, Karolinska Institutet Campus Flemingsberg, Neo Building, Huddinge, Sweden
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Saskia C A de Jager
Saskia C A de Jager
Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
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Patrick C N Rensen
Patrick C N Rensen
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Mariëtte R Boon
Mariëtte R Boon
Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands
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that could enhance energy metabolism ( 15 ). Preclinical experiments have identified two batokines that have a prominent effect on energy balance: fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15) ( 16 , 17 ). FGF21, when
Xiaoli Liu
Xiaoli Liu
Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China
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Lanxiang Liu
Lanxiang Liu
Department of Medical Imaging, The First Hospital of Qinhuangdao, Qinhuangdao, China
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Rui Wang
Rui Wang
Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China
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Xiaojiao Jia
Xiaojiao Jia
Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China
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Binbin Liu
Binbin Liu
Department of Functional Examination, The First Hospital of Qinhuangdao, Qinhuangdao, China
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Ning Ma
Ning Ma
Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China
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Qiang Lu
Qiang Lu
Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, China
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atherosclerosis. It is an accurate, reliable, and noninvasive detection index for the early diagnosis of peripheral arterial diseases ( 6 , 7 ). Fibroblast growth factor 21 (FGF21) is a metabolic regulator that has multiple functions, such as reducing blood
Peiwen Zheng
Peiwen Zheng
School of Mental Health, Wenzhou Medical University, The Affiliated Kangning Hospital, Wenzhou, China
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Fan Wang
Fan Wang
Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China
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Hui Li
Hui Li
Psychosomatic Medicine Research Division, Inner Mongolia Medical University, Huhhot, China
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Hanlu Chen
Hanlu Chen
School of Mental Health, Wenzhou Medical University, The Affiliated Kangning Hospital, Wenzhou, China
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Mengtong Li
Mengtong Li
School of Mental Health, Wenzhou Medical University, The Affiliated Kangning Hospital, Wenzhou, China
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Haozheng Ma
Haozheng Ma
School of Mental Health, Wenzhou Medical University, The Affiliated Kangning Hospital, Wenzhou, China
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Jue He
Jue He
School of Mental Health, Wenzhou Medical University, The Affiliated Kangning Hospital, Wenzhou, China
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Li Chen
Li Chen
School of Mental Health, Wenzhou Medical University, The Affiliated Kangning Hospital, Wenzhou, China
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Yanlong Liu
Yanlong Liu
School of Mental Health, Wenzhou Medical University, The Affiliated Kangning Hospital, Wenzhou, China
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Haiyun Xu
Haiyun Xu
School of Mental Health, Wenzhou Medical University, The Affiliated Kangning Hospital, Wenzhou, China
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levels of fibroblast growth factor 21 (FGF21), zinc, Cu, and iron in CSF. FGF21 is a metabolic cytokine involved in a plethora of tissue-specific effects (23, 24 , 25 , 26 ). Intracellular Zn 2+ plays an important role in mitochondrial function under
Amalie R Lanng
Amalie R Lanng
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
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Lærke S Gasbjerg
Lærke S Gasbjerg
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Natasha C Bergmann
Natasha C Bergmann
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
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Sigrid Bergmann
Sigrid Bergmann
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
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Mads M Helsted
Mads M Helsted
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
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Matthew P Gillum
Matthew P Gillum
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Bolette Hartmann
Bolette Hartmann
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Jens J Holst
Jens J Holst
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Tina Vilsbøll
Tina Vilsbøll
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Steno Diabetes Center Copenhagen, Gentofte, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Steno Diabetes Center Copenhagen, Gentofte, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Filip K Knop
Filip K Knop
Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Gentofte, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Steno Diabetes Center Copenhagen, Gentofte, Denmark
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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constitute a potent stimulator of the liver-derived hormone fibroblast growth factor 21 (FGF21) in humans ( 13 , 14 ). In rodents, FGF21 has been shown to increase insulin sensitivity ( 15 ) and decrease hepatic glucose production, and thus, play an
Raja Padidela
Raja Padidela
Royal Manchester Children’s Hospital and Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
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Moira S Cheung
Moira S Cheung
Evelina London Children’s Hospital, London, UK
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Vrinda Saraff
Vrinda Saraff
Birmingham Women’s and Children’s Hospital, Birmingham, UK
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Poonam Dharmaraj
Poonam Dharmaraj
Alder Hey Children’s NHS Foundation Trust, Liverpool, UK
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variant in the PHEX gene, as a result of which serum FGF23 levels are elevated, resulting in hypophosphataemia. Low serum phosphate reduces hydroxyapatite formation causing osteomalacia and leads to the failure of apoptosis of hypertrophied
Huma Qamar
Huma Qamar
Centre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
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Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
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Nandita Perumal
Nandita Perumal
Centre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada
Department of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
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Department of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
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Eszter Papp
Eszter Papp
Centre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada
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Alison D Gernand
Alison D Gernand
Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania, USA
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Abdullah Al Mahmud
Abdullah Al Mahmud
Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research (icddr,b), Dhaka, Bangladesh
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Daniel E Roth
Daniel E Roth
Centre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
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Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
Department of Paediatrics, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
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calcium-sensing receptor ( 25 ). Fibroblast-like growth factor-23 (FGF23), a marker of bone metabolism, has also been postulated as a regulator of PTH secretion, although the direction of this effect is not yet well characterized ( 26 , 27 , 28 , 29
