Assistance Publique Hôpitaux de Paris (APHP), Department of Endocrinology and Diabetes for Children, Bicêtre Paris-Sud, Le Kremlin Bicêtre, France
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APHP, Plateforme d’Expertise Maladies Rares Paris Sud, Bicêtre Paris Sud Hospital, Le Kremlin Bicêtre, France
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APHP, Plateforme d’Expertise Maladies Rares Paris Sud, Bicêtre Paris Sud Hospital, Le Kremlin Bicêtre, France
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APHP, Plateforme d’Expertise Maladies Rares Paris Sud, Bicêtre Paris Sud Hospital, Le Kremlin Bicêtre, France
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after surgery, the patient still required glucocorticoid replacement. He was treated with growth hormone between the ages of 14 and 17 years because of severe growth retardation. His final height z -score is −1.5. During the mitotane treatment, he began
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. Those patients not eligible for surgery may undergo stereotaxic radiosurgery (SRS) or whole-brain radiotherapy (WBR). RAI can be considered for iodine-avid CNS metastases, under glucocorticoid therapy to minimize the TSH-induced effects and the
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risk is due to untreated GHD, or to confounding factors often found in acquired GHD. Some of these factors such as hypogonadism, excessive glucocorticoid replacement, craniopharyngioma, radiotherapy (implicated in cerebrovascular mortality or de novo
Department of Endocrinology, University of Manchester, School of Medical Sciences, Manchester, UK
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Department of Endocrinology, University of Manchester, School of Medical Sciences, Manchester, UK
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excess is defined by 3 or more units of alcohol daily; glucocorticoid use includes current exposure to oral glucocorticoids or previous exposure for more than 3 months at a dose of prednisolone of 5 mg daily or more; current (but not previous) tobacco
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Faculty of Life Sciences and Medicine, School of Life Course Sciences, King’s College London, London, UK
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Quebec Heart and Lung Institute, Laval University, Quebec, Canada
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Barts and the London School of Medicine, Centre for Endocrinology, William Harvey Institute, London, UK
Neuroendocrine Tumour Unit, Royal Free Hospital, London, UK
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Obesity, Type 2 Diabetes and Immunometabolism Research Group, School of Cardiovascular and Metabolic Medicine & Sciences, Faculty of Life Course Sciences, King’s College London, London, UK
Division of Reproductive Health, Warwick Medical School, University of Warwick, Coventry, UK
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serum cortisol may not accurately reflect the glucocorticoid status of the patient and may lead to unrecognised adrenal insufficiency. Consequently, the altered binding protein profile and heightened risk of adrenal insufficiency lead to patients on
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Department and Graduate Institute of Forensic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
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of the included patients received any kind of glucocorticoid medication before testing. Cross-sectional imaging studies Before AVS, all patients underwent imaging examination, including CT or MRI. All images were reviewed and confirmed by two
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Endocrine Unit, The National Research Centre for the Working Environment, Faculty of Health Sciences, Department of Medicine O, Herlev University Hospital, DK-2730 Herlev, Denmark
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of glucocorticoids enhance hepatic gluconeogenesis and inhibit the secretion and action of insulin leading to insulin resistance (72, 73) . Second, glucocorticoids cause differentiation and proliferation of adipocytes and redistribution of fat
DFBMC, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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DFBMC, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
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stimulates the synthesis and release of glucocorticoids from the zona fasiculata of the adrenal cortex, cortisol in primates and corticosterone in rodents. The biological effects of glucocorticoids support the adaptation to stress-induced demands by
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, high-doses of glucocorticoids (GCSs) ( 3 , 4 ), endocrine irAEs generally do not require cessation of ICI-treatment and rarely require high-dose GCS therapy, although long-term management may be required when persistent ( 5 , 6 ). Interestingly, the
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( 18 , 31 , 33 ). It is well known that hyperfunction of the adrenal cortex in childhood, with elevated secretion of androgens and glucocorticoids, may cause significant disturbance of linear growth. While androgen excess advances growth and BA